PKP1_MOUSE
ID PKP1_MOUSE Reviewed; 728 AA.
AC P97350; B2RSX3;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Plakophilin-1;
GN Name=Pkp1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skin;
RA Nimmrich V., Hunziker A.H., Franke W.W.;
RL Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122 AND SER-143, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Liver, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Seems to play a role in junctional plaques. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cell junction, desmosome
CC {ECO:0000250}. Note=Nuclear and associated with desmosomes.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR EMBL; Y07941; CAA69240.1; -; mRNA.
DR EMBL; BC139041; AAI39042.1; -; mRNA.
DR EMBL; BC139042; AAI39043.1; -; mRNA.
DR CCDS; CCDS15322.1; -.
DR RefSeq; NP_001300630.1; NM_001313701.1.
DR RefSeq; NP_062619.1; NM_019645.3.
DR AlphaFoldDB; P97350; -.
DR SMR; P97350; -.
DR BioGRID; 202212; 16.
DR IntAct; P97350; 9.
DR MINT; P97350; -.
DR STRING; 10090.ENSMUSP00000027667; -.
DR iPTMnet; P97350; -.
DR PhosphoSitePlus; P97350; -.
DR EPD; P97350; -.
DR MaxQB; P97350; -.
DR PaxDb; P97350; -.
DR PeptideAtlas; P97350; -.
DR PRIDE; P97350; -.
DR ProteomicsDB; 289441; -.
DR Antibodypedia; 20641; 211 antibodies from 20 providers.
DR DNASU; 18772; -.
DR Ensembl; ENSMUST00000027667; ENSMUSP00000027667; ENSMUSG00000026413.
DR Ensembl; ENSMUST00000163260; ENSMUSP00000128418; ENSMUSG00000026413.
DR GeneID; 18772; -.
DR KEGG; mmu:18772; -.
DR UCSC; uc007cub.1; mouse.
DR CTD; 5317; -.
DR MGI; MGI:1328359; Pkp1.
DR VEuPathDB; HostDB:ENSMUSG00000026413; -.
DR eggNOG; KOG1048; Eukaryota.
DR GeneTree; ENSGT00940000156735; -.
DR HOGENOM; CLU_009111_3_1_1; -.
DR InParanoid; P97350; -.
DR OMA; SYYTKTQ; -.
DR OrthoDB; 765704at2759; -.
DR PhylomeDB; P97350; -.
DR TreeFam; TF321877; -.
DR Reactome; R-MMU-351906; Apoptotic cleavage of cell adhesion proteins.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR Reactome; R-MMU-6805567; Keratinization.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 18772; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Pkp1; mouse.
DR PRO; PR:P97350; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; P97350; protein.
DR Bgee; ENSMUSG00000026413; Expressed in tail skin and 78 other tissues.
DR ExpressionAtlas; P97350; baseline and differential.
DR Genevisible; P97350; MM.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0001533; C:cornified envelope; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030057; C:desmosome; IDA:MGI.
DR GO; GO:1990124; C:messenger ribonucleoprotein complex; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
DR GO; GO:0005521; F:lamin binding; ISO:MGI.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007043; P:cell-cell junction assembly; IBA:GO_Central.
DR GO; GO:0045110; P:intermediate filament bundle assembly; ISO:MGI.
DR GO; GO:1902373; P:negative regulation of mRNA catabolic process; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR028432; Plakophilin-1.
DR InterPro; IPR028435; Plakophilin/d_Catenin.
DR PANTHER; PTHR10372; PTHR10372; 1.
DR PANTHER; PTHR10372:SF3; PTHR10372:SF3; 1.
DR Pfam; PF00514; Arm; 2.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
PE 1: Evidence at protein level;
KW Cell adhesion; Cell junction; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1..728
FT /note="Plakophilin-1"
FT /id="PRO_0000064285"
FT REPEAT 244..275
FT /note="ARM 1"
FT REPEAT 276..317
FT /note="ARM 2"
FT REPEAT 318..360
FT /note="ARM 3"
FT REPEAT 361..412
FT /note="ARM 4"
FT REPEAT 413..443
FT /note="ARM 5"
FT REPEAT 505..536
FT /note="ARM 6"
FT REPEAT 537..583
FT /note="ARM 7"
FT REPEAT 584..629
FT /note="ARM 8"
FT REPEAT 630..694
FT /note="ARM 9"
FT REGION 48..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 122
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 143
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 728 AA; 80896 MW; BDAC5BA7B4118AC0 CRC64;
MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK RQKSKSSQSS
TLSHSNRGSM YDGLADNYNN YGTTSRSSYF SKFQAGNGSW GYPIYNGTLK REPDNRRFSS
YSQMENWSRH YPRGSCATPG AGSDICFMQK IKASRSEPDL YCDPRGTLRK GTLGSKGHKT
TQNRCSFYST CSGQKAVKKC PVRPPSCTSK QDPVYVPPIS CNKDLSFGHS RASSKICSED
IECSGLTIPK AVQYLCSQDE KYQAIGAYYI QHTCFQDESA KQQVYQLGGI CKLVDLLRSP
NQNVQQAAAG ALRNLVFRST PNKLETRRQN GIREAVSLLR RSGSTEIQKQ LTGLLWNLSS
TDELKEELVA DALPVLTDRV IIPFSGWCDG NSNMSREVVD PEVFFNATGC LRNLSSADAG
RQTMRNYSGL IDSLMAYVQN CVAASRCDDK SVENCMCILH NLSYRLDAEV PTRYRQLEYN
TRNAYTEKSS TGCFSNRGDK MMNNNYDCPL PEEETNPKGS SWLYHSDAIR TYLNLMGKSK
KDATLEACAG ALQNLTASKG LMSNGMSQLI GIKEKGLPQI ARLLQSGNSD VVRSGASLLS
NMSRHPVLHR VMGNQVFPEV TRLLTSHTGN TSNSEDILSS ACYTVRNLMT SQPQMAKQYF
SNSMLNNVFN LCRNTASSPK AAEAARLLLS DMWASKELQS VLRQQGFDRN MMGNIAGANN
LRNFTSRF
