PKP3_BOVIN
ID PKP3_BOVIN Reviewed; 793 AA.
AC Q08DQ0;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Plakophilin-3;
GN Name=PKP3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Ascending colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in junctional plaques. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cell junction, desmosome
CC {ECO:0000250}. Note=Nuclear and associated with desmosomes.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR EMBL; BC123626; AAI23627.1; -; mRNA.
DR RefSeq; NP_001070326.1; NM_001076858.1.
DR AlphaFoldDB; Q08DQ0; -.
DR SMR; Q08DQ0; -.
DR STRING; 9913.ENSBTAP00000055960; -.
DR PaxDb; Q08DQ0; -.
DR PeptideAtlas; Q08DQ0; -.
DR PRIDE; Q08DQ0; -.
DR GeneID; 516247; -.
DR KEGG; bta:516247; -.
DR CTD; 11187; -.
DR eggNOG; KOG1048; Eukaryota.
DR HOGENOM; CLU_009111_2_0_1; -.
DR InParanoid; Q08DQ0; -.
DR OrthoDB; 233858at2759; -.
DR TreeFam; TF321877; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007043; P:cell-cell junction assembly; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR028434; Plakophilin-3.
DR InterPro; IPR028435; Plakophilin/d_Catenin.
DR PANTHER; PTHR10372; PTHR10372; 1.
DR PANTHER; PTHR10372:SF1; PTHR10372:SF1; 1.
DR Pfam; PF00514; Arm; 2.
DR SMART; SM00185; ARM; 4.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion; Cell junction; Methylation; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..793
FT /note="Plakophilin-3"
FT /id="PRO_0000282880"
FT REPEAT 302..345
FT /note="ARM 1"
FT REPEAT 348..387
FT /note="ARM 2"
FT REPEAT 390..429
FT /note="ARM 3"
FT REPEAT 446..484
FT /note="ARM 4"
FT REPEAT 488..533
FT /note="ARM 5"
FT REPEAT 592..633
FT /note="ARM 6"
FT REPEAT 641..680
FT /note="ARM 7"
FT REPEAT 685..726
FT /note="ARM 8"
FT REGION 56..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 81
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT MOD_RES 122
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9QY23"
FT MOD_RES 179
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT MOD_RES 182
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT MOD_RES 239
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT MOD_RES 249
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT MOD_RES 260
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT MOD_RES 310
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT MOD_RES 311
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT MOD_RES 328
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y446"
SQ SEQUENCE 793 AA; 86529 MW; 508D963B1B62C376 CRC64;
MQDGNFLLSA LQPEAGVCSL ALPSDLQLDR RGAEGPEAER LRAARVQEQV RARLLQLGQQ
PRHNGPAEPD GAAEAARGAS RAQYHTLQAG FSSRSQGLGG ETSTFRPIAK PTYSPASWSS
RSAVDLSSSR RLSSVHNGGG AFGAAGYRGA PPTAPVPARP VSFHERGGAG SRADYDTLSL
RSLRLGAGGP DDRYSVVSEQ LEPAATSSYR AFAYERRASS SSSRAGGLDW PEATEGPPSR
TIRAPAMRTL QRFQSSHRSR GVAAGGPGGV LEPVTRAPSV RSLSLGDSGH LPDMRGLDSY
GGHRTLQRLS SGFDDIDLPS AVKYLMASDP NLQVLGAAYI QHKCYSDAAA KKQARSLQAV
PRLVKLFNHA NQEVQRHATG AMRNLVYDNA DNKLALVEEN GIFELLRALR EQDDELRKNV
TGILWNLSSS DHLKDRLARD TLEQLTDLVL SPLSGAGGPP LIQQNASEAE IFYNATGFLR
NLSSASQATR QKMRECHGLV DALVTYINHA LDVGKCEDKS VENAVCVLRN LSYRLYDEMP
PSALQRLEGR GRQDMGVPPG EAVGCFTPQS RRLRELPLTA DALTFAEVSK DPKGLEWLWS
PQIVGLYNRL LQRCELNRHT TEAAAGALQN ITAGDRRWAG VLSRLALEQE RILNPLLDRV
RTADHHQLRS LTGLIRNLSR NARNKDEMST KLVSHLIEKL PGSVGEKSPP ADVLINIIAV
LNNLVVASPV AARDLLYFDG LRKLVFIKKK RDSPDSEKSS RAASSLLANL WQYNKLHRDF
RAKGYRKEDF LGP