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PKP3_BOVIN
ID   PKP3_BOVIN              Reviewed;         793 AA.
AC   Q08DQ0;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Plakophilin-3;
GN   Name=PKP3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in junctional plaques. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cell junction, desmosome
CC       {ECO:0000250}. Note=Nuclear and associated with desmosomes.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR   EMBL; BC123626; AAI23627.1; -; mRNA.
DR   RefSeq; NP_001070326.1; NM_001076858.1.
DR   AlphaFoldDB; Q08DQ0; -.
DR   SMR; Q08DQ0; -.
DR   STRING; 9913.ENSBTAP00000055960; -.
DR   PaxDb; Q08DQ0; -.
DR   PeptideAtlas; Q08DQ0; -.
DR   PRIDE; Q08DQ0; -.
DR   GeneID; 516247; -.
DR   KEGG; bta:516247; -.
DR   CTD; 11187; -.
DR   eggNOG; KOG1048; Eukaryota.
DR   HOGENOM; CLU_009111_2_0_1; -.
DR   InParanoid; Q08DQ0; -.
DR   OrthoDB; 233858at2759; -.
DR   TreeFam; TF321877; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
DR   GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR   GO; GO:0007043; P:cell-cell junction assembly; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR028434; Plakophilin-3.
DR   InterPro; IPR028435; Plakophilin/d_Catenin.
DR   PANTHER; PTHR10372; PTHR10372; 1.
DR   PANTHER; PTHR10372:SF1; PTHR10372:SF1; 1.
DR   Pfam; PF00514; Arm; 2.
DR   SMART; SM00185; ARM; 4.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Cell junction; Methylation; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat.
FT   CHAIN           1..793
FT                   /note="Plakophilin-3"
FT                   /id="PRO_0000282880"
FT   REPEAT          302..345
FT                   /note="ARM 1"
FT   REPEAT          348..387
FT                   /note="ARM 2"
FT   REPEAT          390..429
FT                   /note="ARM 3"
FT   REPEAT          446..484
FT                   /note="ARM 4"
FT   REPEAT          488..533
FT                   /note="ARM 5"
FT   REPEAT          592..633
FT                   /note="ARM 6"
FT   REPEAT          641..680
FT                   /note="ARM 7"
FT   REPEAT          685..726
FT                   /note="ARM 8"
FT   REGION          56..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          221..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         81
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT   MOD_RES         122
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QY23"
FT   MOD_RES         179
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT   MOD_RES         182
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT   MOD_RES         239
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT   MOD_RES         249
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT   MOD_RES         260
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT   MOD_RES         310
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT   MOD_RES         311
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y446"
FT   MOD_RES         328
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y446"
SQ   SEQUENCE   793 AA;  86529 MW;  508D963B1B62C376 CRC64;
     MQDGNFLLSA LQPEAGVCSL ALPSDLQLDR RGAEGPEAER LRAARVQEQV RARLLQLGQQ
     PRHNGPAEPD GAAEAARGAS RAQYHTLQAG FSSRSQGLGG ETSTFRPIAK PTYSPASWSS
     RSAVDLSSSR RLSSVHNGGG AFGAAGYRGA PPTAPVPARP VSFHERGGAG SRADYDTLSL
     RSLRLGAGGP DDRYSVVSEQ LEPAATSSYR AFAYERRASS SSSRAGGLDW PEATEGPPSR
     TIRAPAMRTL QRFQSSHRSR GVAAGGPGGV LEPVTRAPSV RSLSLGDSGH LPDMRGLDSY
     GGHRTLQRLS SGFDDIDLPS AVKYLMASDP NLQVLGAAYI QHKCYSDAAA KKQARSLQAV
     PRLVKLFNHA NQEVQRHATG AMRNLVYDNA DNKLALVEEN GIFELLRALR EQDDELRKNV
     TGILWNLSSS DHLKDRLARD TLEQLTDLVL SPLSGAGGPP LIQQNASEAE IFYNATGFLR
     NLSSASQATR QKMRECHGLV DALVTYINHA LDVGKCEDKS VENAVCVLRN LSYRLYDEMP
     PSALQRLEGR GRQDMGVPPG EAVGCFTPQS RRLRELPLTA DALTFAEVSK DPKGLEWLWS
     PQIVGLYNRL LQRCELNRHT TEAAAGALQN ITAGDRRWAG VLSRLALEQE RILNPLLDRV
     RTADHHQLRS LTGLIRNLSR NARNKDEMST KLVSHLIEKL PGSVGEKSPP ADVLINIIAV
     LNNLVVASPV AARDLLYFDG LRKLVFIKKK RDSPDSEKSS RAASSLLANL WQYNKLHRDF
     RAKGYRKEDF LGP
 
 
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