PKR1_RAT
ID PKR1_RAT Reviewed; 393 AA.
AC Q8R416; Q4AEG4;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Prokineticin receptor 1;
DE Short=PK-R1;
DE AltName: Full=G-protein coupled receptor 73;
DE AltName: Full=G-protein coupled receptor ZAQ;
GN Name=Prokr1; Synonyms=Gpr73, Pkr1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=12054613; DOI=10.1016/s0006-291x(02)00239-5;
RA Masuda Y., Takatsu Y., Terao Y., Kumano S., Ishibashi Y., Suenaga M.,
RA Abe M., Fukusumi S., Watanabe T., Shintani Y., Yamada T., Hinuma S.,
RA Inatomi N., Ohtaki T., Onda H., Fujino M.;
RT "Isolation and identification of EG-VEGF/prokineticins as cognate ligands
RT for two orphan G-protein-coupled receptors.";
RL Biochem. Biophys. Res. Commun. 293:396-402(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Fischer 344/DuCrj, and LEC/Crj;
RX PubMed=15978772; DOI=10.1016/j.ygeno.2005.05.007;
RA Tsuji A.B., Sugyo A., Ogiu T., Sagara M., Kimura T., Ishikawa A., Sudo H.,
RA Ohtsuki M., Aburatani H., Imai T., Harada Y.N.;
RT "Fine mapping of radiation susceptibility and gene expression analysis of
RT LEC congenic rat lines.";
RL Genomics 86:271-279(2005).
CC -!- FUNCTION: Receptor for prokineticin 1. Exclusively coupled to the G(q)
CC subclass of heteromeric G proteins. Activation leads to mobilization of
CC calcium, stimulation of phosphoinositide turnover and activation of
CC p44/p42 mitogen-activated protein kinase. May play a role during early
CC pregnancy (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Widely expressed in peripheral tissues with the
CC highest level in the spleen and moderate levels in the adipose tissues,
CC thymus, lung, kidney, testis, uterus and small intestine.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY089974; AAM11890.1; -; mRNA.
DR EMBL; AB158419; BAE16991.1; -; mRNA.
DR EMBL; AB158420; BAE16992.1; -; mRNA.
DR RefSeq; NP_620433.1; NM_138977.1.
DR RefSeq; XP_006236883.1; XM_006236821.3.
DR AlphaFoldDB; Q8R416; -.
DR SMR; Q8R416; -.
DR STRING; 10116.ENSRNOP00000012913; -.
DR GlyGen; Q8R416; 1 site.
DR PhosphoSitePlus; Q8R416; -.
DR PaxDb; Q8R416; -.
DR Ensembl; ENSRNOT00000012913; ENSRNOP00000012913; ENSRNOG00000009556.
DR GeneID; 192648; -.
DR KEGG; rno:192648; -.
DR UCSC; RGD:708443; rat.
DR CTD; 10887; -.
DR RGD; 708443; Prokr1.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000164891; -.
DR HOGENOM; CLU_009579_6_0_1; -.
DR InParanoid; Q8R416; -.
DR OMA; AYMASEM; -.
DR OrthoDB; 664455at2759; -.
DR PhylomeDB; Q8R416; -.
DR TreeFam; TF315303; -.
DR Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR PRO; PR:Q8R416; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000009556; Expressed in spleen and 2 other tissues.
DR Genevisible; Q8R416; RN.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IMP:RGD.
DR GO; GO:0004983; F:neuropeptide Y receptor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IDA:RGD.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000611; NPY_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..393
FT /note="Prokineticin receptor 1"
FT /id="PRO_0000070081"
FT TOPO_DOM 1..62
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..98
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..145
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..179
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..282
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..322
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..393
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 137..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 393 AA; 44507 MW; C75EC72B97E503A8 CRC64;
METTVGTLGE NTTNTFTDFF SARDGSGAET SPLPFTFSYG DYDMPSDEEE DVTNSRTFFA
AKIVIGMALV GIMLVCGIGN FIFITALARY KKLRNLTNLL IANLAISDFL VAIVCCPFEM
DYYVVRQLSW EHGHVLCASV NYLRTVSLYV STNALLAIAI DRYLAIVHPL RPRMKCQTAA
GLIFLVWSVS ILIAIPAAYF TTETVLVIVE SQEKIFCGQI WPVDQQFYYR SYFLLVFGLE
FVGPVIAMTL CYARVSRELW FKAVPGFQTE QIRRRLRCRR RTVLGLVCVL SAYVLCWAPF
YGFTIVRDFF PSVFVKEKHY LTAFYVVECI AMSNSMINTL CFVTVRNNTS KYLKRILRLQ
WRASPSGSKA SADLDLRTTG IPATEEVDCI RLK
