ID   PKRI1_CHICK             Reviewed;         189 AA.
AC   Q5ZKU0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=PRKR-interacting protein 1 homolog;
GN   Name=PRKRIP1; ORFNames=RCJMB04_9c11;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Required for pre-mRNA splicing as component of the
CC       spliceosome (By similarity). Binds double-stranded RNA (By similarity).
CC       {ECO:0000250|UniProtKB:Q9CWV6, ECO:0000250|UniProtKB:Q9H875}.
CC   -!- SUBUNIT: Component of the pre-catalytic and post-catalytic spliceosome
CC       complexes. {ECO:0000250|UniProtKB:Q9H875}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H875}. Nucleus,
CC       nucleolus {ECO:0000250|UniProtKB:Q9CWV6}.
CC   -!- SIMILARITY: Belongs to the PRKRIP1 family. {ECO:0000305}.
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DR   EMBL; AJ719994; CAG31653.1; -; mRNA.
DR   RefSeq; NP_001006214.1; NM_001006214.2.
DR   AlphaFoldDB; Q5ZKU0; -.
DR   SMR; Q5ZKU0; -.
DR   STRING; 9031.ENSGALP00000002831; -.
DR   PaxDb; Q5ZKU0; -.
DR   PRIDE; Q5ZKU0; -.
DR   Ensembl; ENSGALT00000002834; ENSGALP00000002831; ENSGALG00000001833.
DR   GeneID; 417508; -.
DR   KEGG; gga:417508; -.
DR   CTD; 79706; -.
DR   VEuPathDB; HostDB:geneid_417508; -.
DR   eggNOG; KOG4055; Eukaryota.
DR   GeneTree; ENSGT00390000005003; -.
DR   HOGENOM; CLU_079129_2_0_1; -.
DR   InParanoid; Q5ZKU0; -.
DR   OMA; EPSFIMG; -.
DR   OrthoDB; 1545283at2759; -.
DR   PhylomeDB; Q5ZKU0; -.
DR   TreeFam; TF314382; -.
DR   PRO; PR:Q5ZKU0; -.
DR   Proteomes; UP000000539; Chromosome 19.
DR   Bgee; ENSGALG00000001833; Expressed in ovary and 14 other tissues.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0004860; F:protein kinase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0006469; P:negative regulation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:0003014; P:renal system process; IEA:Ensembl.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR009548; Prkrip1.
DR   PANTHER; PTHR13507; PTHR13507; 1.
DR   Pfam; PF06658; DUF1168; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..189
FT                   /note="PRKR-interacting protein 1 homolog"
FT                   /id="PRO_0000324790"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          49..141
FT                   /note="Required for RNA-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          113..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          124..136
FT                   /note="Required for nuclear localization"
FT                   /evidence="ECO:0000250"
FT   COILED          89..181
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..17
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..158
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..180
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   189 AA;  22375 MW;  0F43B2DEF862669F CRC64;
     MAAPSAPRPP RPRKEPQPLV IPRNAAEEQR LRLERLMRNP EKTVPIPEKL NEWAPRPPPE
     FVRDVMGSSA GAGSGEFHVY RHLRRREYQR QDFMDAMAEK QRLDEEFQKK LERNKMIAEE
     QTAKRRRKRQ KLKEKKLQAK KNKLEQKKQE KESDQSQERV SSEDDEEDSK EEEEKEDDAE
     EPSFVMGRG