PKRI1_DANRE
ID PKRI1_DANRE Reviewed; 182 AA.
AC Q568A0;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=PRKR-interacting protein 1 homolog;
GN Name=prkrip1; ORFNames=si:dkey-93f15.1, zgc:110608;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for pre-mRNA splicing as component of the
CC spliceosome (By similarity). Binds double-stranded RNA (By similarity).
CC {ECO:0000250|UniProtKB:Q9CWV6, ECO:0000250|UniProtKB:Q9H875}.
CC -!- SUBUNIT: Component of the pre-catalytic and post-catalytic spliceosome
CC complexes. {ECO:0000250|UniProtKB:Q9H875}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H875}. Nucleus,
CC nucleolus {ECO:0000250|UniProtKB:Q9CWV6}.
CC -!- SIMILARITY: Belongs to the PRKRIP1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR376863; CAM16495.1; -; Genomic_DNA.
DR EMBL; BC092949; AAH92949.1; -; mRNA.
DR EMBL; BC152130; AAI52131.1; -; mRNA.
DR RefSeq; NP_001017896.1; NM_001017896.2.
DR AlphaFoldDB; Q568A0; -.
DR SMR; Q568A0; -.
DR STRING; 7955.ENSDARP00000045517; -.
DR PaxDb; Q568A0; -.
DR Ensembl; ENSDART00000045518; ENSDARP00000045517; ENSDARG00000033126.
DR GeneID; 550595; -.
DR KEGG; dre:550595; -.
DR CTD; 79706; -.
DR ZFIN; ZDB-GENE-111011-2; prkrip1.
DR eggNOG; KOG4055; Eukaryota.
DR GeneTree; ENSGT00390000005003; -.
DR HOGENOM; CLU_079129_2_0_1; -.
DR InParanoid; Q568A0; -.
DR OMA; EPSFIMG; -.
DR OrthoDB; 1545283at2759; -.
DR PhylomeDB; Q568A0; -.
DR TreeFam; TF314382; -.
DR PRO; PR:Q568A0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000033126; Expressed in cleaving embryo and 26 other tissues.
DR ExpressionAtlas; Q568A0; baseline.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; IBA:GO_Central.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR009548; Prkrip1.
DR PANTHER; PTHR13507; PTHR13507; 1.
DR Pfam; PF06658; DUF1168; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Spliceosome.
FT CHAIN 1..182
FT /note="PRKR-interacting protein 1 homolog"
FT /id="PRO_0000324791"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..143
FT /note="Required for RNA-binding"
FT /evidence="ECO:0000250"
FT REGION 114..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..138
FT /note="Required for nuclear localization"
FT /evidence="ECO:0000250"
FT COILED 99..157
FT /evidence="ECO:0000255"
FT COMPBIAS 29..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 182 AA; 21094 MW; C396D3A0DEC3F452 CRC64;
MAVENKDARP GKALKKESQP LIIAKTPAEE QRLKLERLMR NPDKAAPIPE KPKEWNPRAP
PEFVRDVMGS SAGAGSGEFH VYRHLRRREY QRQDFLERLS EKQKLDEEYK EKLIENQKAA
EDRTAKRRKK REKLKQKKLM AKKAKMESQK EEDSEKSSSS SASEGEEKDD DAEVPSFIMG
KR
