ID   PKRI1_XENLA             Reviewed;         173 AA.
AC   Q6GNG8;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=PRKR-interacting protein 1 homolog;
GN   Name=prkrip1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for pre-mRNA splicing as component of the
CC       spliceosome (By similarity). Binds double-stranded RNA (By similarity).
CC       {ECO:0000250|UniProtKB:Q9CWV6, ECO:0000250|UniProtKB:Q9H875}.
CC   -!- SUBUNIT: Component of the pre-catalytic and post-catalytic spliceosome
CC       complexes. {ECO:0000250|UniProtKB:Q9H875}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H875}. Nucleus,
CC       nucleolus {ECO:0000250|UniProtKB:Q9CWV6}.
CC   -!- SIMILARITY: Belongs to the PRKRIP1 family. {ECO:0000305}.
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DR   EMBL; BC073544; AAH73544.1; -; mRNA.
DR   RefSeq; NP_001085923.1; NM_001092454.1.
DR   RefSeq; XP_018100559.1; XM_018245070.1.
DR   AlphaFoldDB; Q6GNG8; -.
DR   SMR; Q6GNG8; -.
DR   MaxQB; Q6GNG8; -.
DR   GeneID; 444352; -.
DR   KEGG; xla:444352; -.
DR   CTD; 444352; -.
DR   Xenbase; XB-GENE-986511; prkrip1.L.
DR   OMA; EPSFIMG; -.
DR   OrthoDB; 1545283at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 444352; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR009548; Prkrip1.
DR   PANTHER; PTHR13507; PTHR13507; 1.
DR   Pfam; PF06658; DUF1168; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..173
FT                   /note="PRKR-interacting protein 1 homolog"
FT                   /id="PRO_0000324792"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          50..142
FT                   /note="Required for RNA-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          117..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..137
FT                   /note="Required for nuclear localization"
FT                   /evidence="ECO:0000250"
FT   COILED          99..150
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        28..59
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..143
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..173
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   173 AA;  20319 MW;  04762F54AD9A81C9 CRC64;
     MAKETGTAKP ARQKKEPQPL VIPKNATDEQ RLKLERLMRN PDKPATVPER PKEWSPRSAP
     EFVRDVMGSS AGAGSGEFHV YRHLRRREYQ RQEFLDGMSE KQRLDEEYKK KLIQNKMLEE
     ERTAKRRLKR QKLKEKKKMC KKGKKEEKKE DKDGHTDPEN SAESSDKSDL EDQ