PKRI1_XENTR
ID PKRI1_XENTR Reviewed; 173 AA.
AC Q28IN9;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=PRKR-interacting protein 1 homolog;
GN Name=prkrip1; ORFNames=TNeu032k09.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for pre-mRNA splicing as component of the
CC spliceosome (By similarity). Binds double-stranded RNA (By similarity).
CC {ECO:0000250|UniProtKB:Q9CWV6, ECO:0000250|UniProtKB:Q9H875}.
CC -!- SUBUNIT: Component of the pre-catalytic and post-catalytic spliceosome
CC complexes. {ECO:0000250|UniProtKB:Q9H875}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H875}. Nucleus,
CC nucleolus {ECO:0000250|UniProtKB:Q9CWV6}.
CC -!- SIMILARITY: Belongs to the PRKRIP1 family. {ECO:0000305}.
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DR EMBL; CR760297; CAJ82854.1; -; mRNA.
DR EMBL; BC159011; AAI59012.1; -; mRNA.
DR RefSeq; NP_001017225.1; NM_001017225.2.
DR RefSeq; XP_012812502.1; XM_012957048.2.
DR RefSeq; XP_017946768.1; XM_018091279.1.
DR AlphaFoldDB; Q28IN9; -.
DR SMR; Q28IN9; -.
DR Ensembl; ENSXETT00000053056; ENSXETP00000053056; ENSXETG00000024610.
DR GeneID; 549979; -.
DR KEGG; xtr:549979; -.
DR CTD; 79706; -.
DR Xenbase; XB-GENE-986508; prkrip1.
DR InParanoid; Q28IN9; -.
DR OrthoDB; 1545283at2759; -.
DR PhylomeDB; Q28IN9; -.
DR Proteomes; UP000008143; Chromosome 2.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000024610; Expressed in 2-cell stage embryo and 12 other tissues.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; IBA:GO_Central.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR009548; Prkrip1.
DR PANTHER; PTHR13507; PTHR13507; 1.
DR Pfam; PF06658; DUF1168; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Spliceosome.
FT CHAIN 1..173
FT /note="PRKR-interacting protein 1 homolog"
FT /id="PRO_0000324793"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..142
FT /note="Required for RNA-binding"
FT /evidence="ECO:0000250"
FT REGION 115..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..137
FT /note="Required for nuclear localization"
FT /evidence="ECO:0000250"
FT COILED 99..161
FT /evidence="ECO:0000255"
FT COMPBIAS 140..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 173 AA; 20348 MW; 8E4D75B316D2FB48 CRC64;
MAAETGTAKP ARAKKEPQPL VIPKNATDEQ RLRLERLMRN PDKLAAIPER PKEWSPRSAP
EFVRDVMGSS AGAGSGEFHV YRHLRRREYQ RQEFLDRVSE KHNLDDDFQR KLMENKKLEE
EKTAKRRLKR QKLKEKKKMA KMAKKEEKKE EIEKHVELDN SPESSDKSDL EDQ
