PKS10_MYCBO
ID PKS10_MYCBO Reviewed; 353 AA.
AC Q7VEV2; A0A1R3XYX2; X2BIL0;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Polyketide synthase-like Pks10;
DE EC=2.3.1.-;
DE AltName: Full=Chalcone synthase-like protein;
DE Short=CHS-like;
DE AltName: Full=Polyketide synthase type III Pks10;
GN Name=pks10; OrderedLocusNames=BQ2027_MB1688;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- FUNCTION: Could catalyze the elongation of hydroxybenzoyl-CoA as well
CC as elongation of the aliphatic precursor involved in the synthesis of
CC phthiocerol dimycocerosate (DIM). {ECO:0000250}.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000305}.
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DR EMBL; LT708304; SIU00291.1; -; Genomic_DNA.
DR RefSeq; NP_855340.1; NC_002945.3.
DR RefSeq; WP_003408181.1; NC_002945.4.
DR AlphaFoldDB; Q7VEV2; -.
DR SMR; Q7VEV2; -.
DR EnsemblBacteria; SIU00291; SIU00291; BQ2027_MB1688.
DR GeneID; 45425630; -.
DR PATRIC; fig|233413.5.peg.1841; -.
DR OMA; GQESPFM; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; PTHR11877; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; SSF53901; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Fatty acid metabolism; Lipid metabolism; Transferase.
FT CHAIN 1..353
FT /note="Polyketide synthase-like Pks10"
FT /id="PRO_0000407317"
FT ACT_SITE 138
FT /evidence="ECO:0000250"
SQ SEQUENCE 353 AA; 37146 MW; 5B681D1E8D53C2DA CRC64;
MSVIAGVFGA LPPYRYSQRE LTDSFVSIPD FEGYEDIVRQ LHASAKVNSR HLVLPLEKYP
KLTDFGEANK IFIEKAVDLG VQALAGALDE SGLRPEDLDV LITATVTGLA VPSLDARIAG
RLGLRADVRR VPLFGLGCVA GAAGVARLHD YLRGAPDGVA ALVSVELCSL TYPGYKPTLP
GLVGSALFAD GAAAVVAAGV KRAQDIGADG PDILDSRSHL YPDSLRTMGY DVGSAGFELV
LSRDLAAVVE QYLGNDVTTF LASHGLSTTD VGAWVTHPGG PKIINAITET LDLSPQALEL
TWRSLGEIGN LSSASVLHVL RDTIAKPPPS GSPGLMIAMG PGFCSELVLL RWH