ID   PKSG1_CANSA             Reviewed;         385 AA.
AC   F1LKH6;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Polyketide synthase 1;
DE            EC=2.3.1.-;
GN   Name=PKSG1;
OS   Cannabis sativa (Hemp) (Marijuana).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Cannabaceae; Cannabis.
OX   NCBI_TaxID=3483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], 3D-STRUCTURE MODELING, AND TISSUE SPECIFICITY.
RX   PubMed=21637580; DOI=10.1590/s1415-47572010005000088;
RA   Flores-Sanchez I.J., Linthorst H.J., Verpoorte R.;
RT   "In silicio expression analysis of PKS genes isolated from Cannabis sativa
RT   L.";
RL   Genet. Mol. Biol. 33:703-713(2010).
CC   -!- FUNCTION: Polyketide synthase responsible for the biosynthesis of
CC       secondary metabolites. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in glandular trichomes.
CC       {ECO:0000269|PubMed:21637580}.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EU551163; ACD76853.1; -; mRNA.
DR   AlphaFoldDB; F1LKH6; -.
DR   SMR; F1LKH6; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Cytoplasm; Transferase.
FT   CHAIN           1..385
FT                   /note="Polyketide synthase 1"
FT                   /id="PRO_0000421148"
FT   ACT_SITE        157
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ   SEQUENCE   385 AA;  42507 MW;  7E84F29B0DD003C0 CRC64;
     MNHLRAEGPA SVLAIGTANP ENILIQDEFP DYYFRVTKSE HMTQLKEKFR KICDKSMIRK
     RNIFLNEEHL KQNPKLVEHD VQTLDARQDM LVVEVPKLGK DACAKAIKEW GQPKSKITHL
     IFTSASTTDM PGADYHCAKL LGLSPSVKRV MMYQLGCYGG GTVLRIAKDI AENNKGARVL
     AVCCDIMACL FRGPSDSDLE LLVGQAIFGD GAAAVIVGAE PDESVGERPI FELVSTGQTI
     LPNSEGTIGG HIREAGLIFD LHKDVPMLIS NNIEKCLIEA FTPIGISDWN SIFWITHPGG
     KAILDKVEEK LHLKSDKFVD SRHVLSEHGN MSSSTVLFVM DELRKRSLEE GKSTTGDGFE
     WGVLFGFGPG LTVERVVVRS VPIKY