ID   PKSG4_CANSA             Reviewed;         385 AA.
AC   F1LKH8;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Polyketide synthase 4;
DE            EC=2.3.1.-;
GN   Name=PKSG4;
OS   Cannabis sativa (Hemp) (Marijuana).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Cannabaceae; Cannabis.
OX   NCBI_TaxID=3483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], 3D-STRUCTURE MODELING, AND TISSUE SPECIFICITY.
RX   PubMed=21637580; DOI=10.1590/s1415-47572010005000088;
RA   Flores-Sanchez I.J., Linthorst H.J., Verpoorte R.;
RT   "In silicio expression analysis of PKS genes isolated from Cannabis sativa
RT   L.";
RL   Genet. Mol. Biol. 33:703-713(2010).
CC   -!- FUNCTION: Polyketide synthase responsible for the biosynthesis of
CC       secondary metabolites. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in glandular trichomes.
CC       {ECO:0000269|PubMed:21637580}.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
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DR   EMBL; EU551165; ACD76855.1; -; mRNA.
DR   AlphaFoldDB; F1LKH8; -.
DR   SMR; F1LKH8; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Cytoplasm; Transferase.
FT   CHAIN           1..385
FT                   /note="Polyketide synthase 4"
FT                   /id="PRO_0000421151"
FT   ACT_SITE        157
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ   SEQUENCE   385 AA;  42604 MW;  140689928D155D15 CRC64;
     MNHLRAEGPA SVLAIGTANP ENILIQDEFP DYYFRVTKSE HMTQLKEKFR KICDKSMIRK
     RNCFLNEEHL KQNPRLVEHE MQTLDARQDM LVVEVPKLGK DACAKAIKEW GQPKSKITHL
     IFTSASTTDM PGADYHCAKL LGLSPSVKRV MMYQLGCYGG GTVLRIAKDI AENNKGARVL
     AVCCDIMACL FRGPSDSDLE LLVGQAIFGD GAAAVIVGAE PDESVGERPI FELVSTGQTI
     LPNSEGTIGG HIREAGLIFD LHKDVPMLIS NNIEKCLIEA FTPIGISDWN SIFWITHPGG
     KAILDKVEEK LDLKKEKFVD SRHVLSEHGN MSSSTVLFVM DELRKRSLEE GKSTTGDGFE
     WGVLFGFGPG LTVERVVVRS VPIKY