PLAC1_HUMAN
ID PLAC1_HUMAN Reviewed; 212 AA.
AC Q9HBJ0;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Placenta-specific protein 1;
DE Flags: Precursor;
GN Name=PLAC1 {ECO:0000312|EMBL:AAG22596.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAG22596.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=10995572; DOI=10.1006/geno.2000.6302;
RA Cocchia M., Huber R., Pantano S., Chen E.Y., Ma P., Forabosco A.,
RA Ko M.S.H., Schlessinger D.;
RT "PLAC1, an Xq26 gene with placenta-specific expression.";
RL Genomics 68:305-312(2000).
RN [2] {ECO:0000312|EMBL:BAC11392.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta {ECO:0000312|EMBL:BAC11392.1};
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3] {ECO:0000312|EMBL:AAH22335.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta {ECO:0000312|EMBL:AAH22335.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305}
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=12412044; DOI=10.1002/mrd.10200;
RA Fant M., Weisoly D.L., Cocchia M., Huber R., Khan S., Lunt T.,
RA Schlessinger D.;
RT "PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in
RT the human placenta and modulated by keratinocyte growth factor.";
RL Mol. Reprod. Dev. 63:430-436(2002).
RN [5] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=15608456; DOI=10.1159/000081365;
RA Concu M., Banzola I., Farina A., Sekizawa A., Rizzo N., Marini M.,
RA Caramelli E., Carinci P.;
RT "Rapid clearance of mRNA for PLAC1 gene in maternal blood after delivery.";
RL Fetal Diagn. Ther. 20:27-30(2005).
RN [6] {ECO:0000305}
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=15803460; DOI=10.1002/mrd.20272;
RA Massabbal E., Parveen S., Weisoly D.L., Nelson D.M., Smith S.D., Fant M.;
RT "PLAC1 expression increases during trophoblast differentiation: evidence
RT for regulatory interactions with the fibroblast growth factor-7 (FGF-7)
RT axis.";
RL Mol. Reprod. Dev. 71:299-304(2005).
CC -!- FUNCTION: May play a role in placental development.
CC {ECO:0000269|PubMed:10995572}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in placenta. Localizes primarily to
CC differentiated syncytiotrophoblast throughout gestation as well as to a
CC small population of villous cytotrophoblasts. Also detected in maternal
CC blood and rapidly disappears following delivery, but is not detected in
CC other adult or fetal tissues examined. {ECO:0000269|PubMed:10995572,
CC ECO:0000269|PubMed:12412044, ECO:0000269|PubMed:15608456,
CC ECO:0000269|PubMed:15803460}.
CC -!- INDUCTION: Up-regulated during trophoblast differentiation and by FGF7
CC in trophoblast cells. {ECO:0000269|PubMed:12412044,
CC ECO:0000269|PubMed:15803460}.
CC -!- SIMILARITY: Belongs to the PLAC1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF234654; AAG22596.1; -; mRNA.
DR EMBL; AK075086; BAC11392.1; -; mRNA.
DR EMBL; BC022335; AAH22335.1; -; mRNA.
DR EMBL; BC066327; AAH66327.1; -; mRNA.
DR CCDS; CCDS14642.1; -.
DR RefSeq; NP_001303816.1; NM_001316887.1.
DR RefSeq; NP_001303817.1; NM_001316888.1.
DR RefSeq; NP_001303818.1; NM_001316889.1.
DR RefSeq; NP_068568.1; NM_021796.3.
DR RefSeq; XP_011529559.1; XM_011531257.2.
DR RefSeq; XP_011529562.1; XM_011531260.2.
DR RefSeq; XP_016884725.1; XM_017029236.1.
DR AlphaFoldDB; Q9HBJ0; -.
DR SMR; Q9HBJ0; -.
DR BioGRID; 115981; 25.
DR IntAct; Q9HBJ0; 17.
DR STRING; 9606.ENSP00000352173; -.
DR iPTMnet; Q9HBJ0; -.
DR PhosphoSitePlus; Q9HBJ0; -.
DR BioMuta; PLAC1; -.
DR DMDM; 74734251; -.
DR MassIVE; Q9HBJ0; -.
DR MaxQB; Q9HBJ0; -.
DR PaxDb; Q9HBJ0; -.
DR PeptideAtlas; Q9HBJ0; -.
DR PRIDE; Q9HBJ0; -.
DR ProteomicsDB; 81563; -.
DR Antibodypedia; 44877; 159 antibodies from 26 providers.
DR DNASU; 10761; -.
DR Ensembl; ENST00000359237.9; ENSP00000352173.4; ENSG00000170965.10.
DR GeneID; 10761; -.
DR KEGG; hsa:10761; -.
DR MANE-Select; ENST00000359237.9; ENSP00000352173.4; NM_021796.4; NP_068568.1.
DR UCSC; uc004exo.2; human.
DR CTD; 10761; -.
DR DisGeNET; 10761; -.
DR GeneCards; PLAC1; -.
DR HGNC; HGNC:9044; PLAC1.
DR HPA; ENSG00000170965; Tissue enriched (placenta).
DR MIM; 300296; gene.
DR neXtProt; NX_Q9HBJ0; -.
DR OpenTargets; ENSG00000170965; -.
DR PharmGKB; PA33371; -.
DR VEuPathDB; HostDB:ENSG00000170965; -.
DR eggNOG; ENOG502RMFF; Eukaryota.
DR GeneTree; ENSGT00530000064049; -.
DR HOGENOM; CLU_118376_0_0_1; -.
DR InParanoid; Q9HBJ0; -.
DR OMA; GLGCPAN; -.
DR OrthoDB; 1276986at2759; -.
DR PhylomeDB; Q9HBJ0; -.
DR TreeFam; TF338479; -.
DR PathwayCommons; Q9HBJ0; -.
DR SignaLink; Q9HBJ0; -.
DR BioGRID-ORCS; 10761; 17 hits in 693 CRISPR screens.
DR ChiTaRS; PLAC1; human.
DR GeneWiki; PLAC1; -.
DR GenomeRNAi; 10761; -.
DR Pharos; Q9HBJ0; Tbio.
DR PRO; PR:Q9HBJ0; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9HBJ0; protein.
DR Bgee; ENSG00000170965; Expressed in placenta and 85 other tissues.
DR Genevisible; Q9HBJ0; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001890; P:placenta development; IEP:UniProtKB.
DR InterPro; IPR033220; PLAC1.
DR InterPro; IPR033222; PLAC1_fam.
DR PANTHER; PTHR14380; PTHR14380; 1.
DR PANTHER; PTHR14380:SF2; PTHR14380:SF2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..212
FT /note="Placenta-specific protein 1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000251144"
SQ SEQUENCE 212 AA; 23616 MW; D449300A597DD023 CRC64;
MKVFKFIGLM ILLTSAFSAG SGQSPMTVLC SIDWFMVTVH PFMLNNDVCV HFHELHLGLG
CPPNHVQPHA YQFTYRVTEC GIRAKAVSQD MVIYSTEIHY SSKGTPSKFV IPVSCAAPQK
SPWLTKPCSM RVASKSRATA QKDEKCYEVF SLSQSSQRPN CDCPPCVFSE EEHTQVPCHQ
AGAQEAQPLQ PSHFLDISED WSLHTDDMIG SM
