PLAC1_MOUSE
ID PLAC1_MOUSE Reviewed; 173 AA.
AC Q9JI83; Q3UKT4; Q80WW3;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Placenta-specific protein 1;
DE AltName: Full=EPCS26;
DE Flags: Precursor;
GN Name=Plac1 {ECO:0000312|MGI:MGI:1926287};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAF81275.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10885754; DOI=10.1006/dbio.2000.9705;
RA Hemberger M., Himmelbauer H., Ruschmann J., Zeitz C., Fundele R.;
RT "cDNA subtraction cloning reveals novel genes whose temporal and spatial
RT expression indicates association with trophoblast invasion.";
RL Dev. Biol. 222:158-169(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAG22595.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=10995572; DOI=10.1006/geno.2000.6302;
RA Cocchia M., Huber R., Pantano S., Chen E.Y., Ma P., Forabosco A.,
RA Ko M.S.H., Schlessinger D.;
RT "PLAC1, an Xq26 gene with placenta-specific expression.";
RL Genomics 68:305-312(2000).
RN [3] {ECO:0000312|EMBL:BAB24083.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB24083.1};
RC TISSUE=Placenta {ECO:0000312|EMBL:BAB24083.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4] {ECO:0000312|EMBL:AAH51666.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH51666.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH51666.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in placental development.
CC {ECO:0000269|PubMed:10995572}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in placenta.
CC {ECO:0000269|PubMed:10995572}.
CC -!- DEVELOPMENTAL STAGE: Strongly expressed at 7 dpc and gradually declines
CC with the progression of embryogenesis. Expression detected from 7.5 to
CC 14.5 dpc in ectoplacental cone, trophoblast giant cells, and
CC labyrinthine trophoblasts. {ECO:0000269|PubMed:10995572}.
CC -!- SIMILARITY: Belongs to the PLAC1 family. {ECO:0000305}.
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DR EMBL; AF250838; AAF81275.1; -; mRNA.
DR EMBL; AF234653; AAG22595.1; -; mRNA.
DR EMBL; AK005501; BAB24083.1; -; mRNA.
DR EMBL; AK145876; BAE26717.1; -; mRNA.
DR EMBL; BC051666; AAH51666.1; -; mRNA.
DR CCDS; CCDS30128.1; -.
DR RefSeq; NP_062411.1; NM_019538.4.
DR RefSeq; XP_006541587.1; XM_006541524.1.
DR RefSeq; XP_006541588.1; XM_006541525.1.
DR RefSeq; XP_011249318.1; XM_011251016.2.
DR AlphaFoldDB; Q9JI83; -.
DR SMR; Q9JI83; -.
DR STRING; 10090.ENSMUSP00000110492; -.
DR iPTMnet; Q9JI83; -.
DR PhosphoSitePlus; Q9JI83; -.
DR PaxDb; Q9JI83; -.
DR PRIDE; Q9JI83; -.
DR ProteomicsDB; 289667; -.
DR Antibodypedia; 44877; 159 antibodies from 26 providers.
DR Ensembl; ENSMUST00000074861; ENSMUSP00000074404; ENSMUSG00000061082.
DR Ensembl; ENSMUST00000114843; ENSMUSP00000110492; ENSMUSG00000061082.
DR Ensembl; ENSMUST00000174390; ENSMUSP00000133862; ENSMUSG00000061082.
DR GeneID; 56096; -.
DR KEGG; mmu:56096; -.
DR UCSC; uc009tet.1; mouse.
DR CTD; 10761; -.
DR MGI; MGI:1926287; Plac1.
DR VEuPathDB; HostDB:ENSMUSG00000061082; -.
DR eggNOG; ENOG502RMFF; Eukaryota.
DR GeneTree; ENSGT00530000064049; -.
DR HOGENOM; CLU_118376_0_0_1; -.
DR InParanoid; Q9JI83; -.
DR OMA; GLGCPAN; -.
DR OrthoDB; 1276986at2759; -.
DR PhylomeDB; Q9JI83; -.
DR TreeFam; TF338479; -.
DR BioGRID-ORCS; 56096; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q9JI83; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9JI83; protein.
DR Bgee; ENSMUSG00000061082; Expressed in ectoplacental cone and 94 other tissues.
DR Genevisible; Q9JI83; MM.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0001890; P:placenta development; IEP:UniProtKB.
DR GO; GO:0090214; P:spongiotrophoblast layer developmental growth; IMP:MGI.
DR InterPro; IPR033220; PLAC1.
DR InterPro; IPR033222; PLAC1_fam.
DR PANTHER; PTHR14380; PTHR14380; 1.
DR PANTHER; PTHR14380:SF2; PTHR14380:SF2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..173
FT /note="Placenta-specific protein 1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000251145"
FT CONFLICT 69
FT /note="H -> R (in Ref. 4; AAH51666)"
FT /evidence="ECO:0000305"
FT CONFLICT 157
FT /note="E -> G (in Ref. 4; AAH51666)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="P -> R (in Ref. 3; BAE26717)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 173 AA; 19626 MW; 674AEF2B68181162 CRC64;
MNLRKFLGGT VLVAFMLFSY SEQNQVNVLC STDWFMVTVH PFLLNNDVYV HFYEVHLGLG
CPPNHVHPHF YQFHYRVTEC GIRIKAVSPD VVIYSSEIHY ASKGSSTKYV IPVSCAAPRR
SPWLTKPYSA KAPSNNMGAT PKNDTSYHVF TLPEPSEQPN CSCPPYVYNQ KSM
