ID   PLAC4_HUMAN             Reviewed;         150 AA.
AC   Q8WY50;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 2.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Placenta-specific protein 4;
GN   Name=PLAC4; Synonyms=C21orf115, D21S418E; ORFNames=PP1416;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA   Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA   Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA   Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT   "Large-scale cDNA transfection screening for genes related to cancer
RT   development and progression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA   Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA   Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA   Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA   Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA   Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA   Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA   Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA   Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA   Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA   Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=8406465; DOI=10.1006/geno.1993.1317;
RA   Kido S., Sakuragi N., Bronner M.P., Sayegh R., Berger R., Patterson D.,
RA   Strauss J.F. III;
RT   "D21S418E identifies a cAMP-regulated gene located on chromosome 21q22.3
RT   that is expressed in placental syncytiotrophoblast and choriocarcinoma
RT   cells.";
RL   Genomics 17:256-259(1993).
CC   -!- TISSUE SPECIFICITY: Expressed in placental syncytiotrophoblast and
CC       choriocarcinoma cells. {ECO:0000269|PubMed:8406465}.
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DR   EMBL; AF269287; AAG23170.1; -; mRNA.
DR   RefSeq; NP_878252.2; NM_182832.2.
DR   AlphaFoldDB; Q8WY50; -.
DR   BioGRID; 128150; 1.
DR   BioMuta; PLAC4; -.
DR   PRIDE; Q8WY50; -.
DR   GeneCards; PLAC4; -.
DR   HGNC; HGNC:14616; PLAC4.
DR   MIM; 613770; gene.
DR   neXtProt; NX_Q8WY50; -.
DR   PharmGKB; PA33374; -.
DR   OrthoDB; 753343at2759; -.
DR   PathwayCommons; Q8WY50; -.
DR   BioGRID-ORCS; 191585; 5 hits in 161 CRISPR screens.
DR   ChiTaRS; PLAC4; human.
DR   GenomeRNAi; 191585; -.
DR   Pharos; Q8WY50; Tdark.
DR   PRO; PR:Q8WY50; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q8WY50; protein.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..150
FT                   /note="Placenta-specific protein 4"
FT                   /id="PRO_0000299058"
FT   CONFLICT        41
FT                   /note="P -> H (in Ref. 1; AAG23170)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   150 AA;  16680 MW;  F7F4C7C6E89EA918 CRC64;
     MKELLRLKHC KHLLTTHVHS PWTPSLTLTP SLLTLDTLTH PRHRHSSPWT PHSAPWTPSL
     TLDTFTHPDT LTHPGHPHSP WIPSLLTLDT LTHPGYPHSS PWTLSLTLTP SILTLDSLTP
     HPGLPHSSPW TPSLLILDTL TQPGHPHSSP