PLAC8_HUMAN
ID PLAC8_HUMAN Reviewed; 115 AA.
AC Q9NZF1; C1K3N2;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Placenta-specific gene 8 protein;
DE AltName: Full=Protein C15;
GN Name=PLAC8; ORFNames=BM-004;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Plasmacytoid dendritic cell;
RX PubMed=12384430; DOI=10.1182/blood-2002-02-0638;
RA Rissoan M.-C., Duhen T., Bridon J.-M., Bendriss-Vermare N., Peronne C.,
RA de Saint-Vis B.M., Briere F., Bates E.E.M.;
RT "Subtractive hybridization reveals the expression of immunoglobulin like
RT transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human
RT plasmacytoid dendritic cells.";
RL Blood 100:3295-3303(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RA Guan W.J., Ma Y.H., Yu L.L.;
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- TISSUE SPECIFICITY: Expressed at high levels in plasmacytoid dendritic
CC cells. High expression in spleen, lymph nodes, peripheral blood
CC leukocytes, and bone marrow, with lower expression in thymus, appendix,
CC and fetal liver.
CC -!- SIMILARITY: Belongs to the cornifelin family. {ECO:0000305}.
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DR EMBL; AJ422147; CAD19530.1; -; mRNA.
DR EMBL; FJ795024; ACO37643.1; -; mRNA.
DR EMBL; AF208846; AAF64260.1; -; mRNA.
DR EMBL; CH471057; EAX05923.1; -; Genomic_DNA.
DR CCDS; CCDS3601.1; -.
DR RefSeq; NP_001124187.1; NM_001130715.1.
DR RefSeq; NP_001124188.1; NM_001130716.1.
DR RefSeq; NP_057703.1; NM_016619.2.
DR AlphaFoldDB; Q9NZF1; -.
DR BioGRID; 119467; 26.
DR IntAct; Q9NZF1; 2.
DR STRING; 9606.ENSP00000399700; -.
DR PhosphoSitePlus; Q9NZF1; -.
DR BioMuta; PLAC8; -.
DR DMDM; 34922849; -.
DR MassIVE; Q9NZF1; -.
DR PaxDb; Q9NZF1; -.
DR PeptideAtlas; Q9NZF1; -.
DR PRIDE; Q9NZF1; -.
DR ProteomicsDB; 83383; -.
DR Antibodypedia; 52449; 72 antibodies from 18 providers.
DR DNASU; 51316; -.
DR Ensembl; ENST00000311507.9; ENSP00000309509.4; ENSG00000145287.11.
DR Ensembl; ENST00000411416.6; ENSP00000412230.2; ENSG00000145287.11.
DR Ensembl; ENST00000426923.2; ENSP00000399700.2; ENSG00000145287.11.
DR Ensembl; ENST00000505406.5; ENSP00000422526.1; ENSG00000145287.11.
DR GeneID; 51316; -.
DR KEGG; hsa:51316; -.
DR MANE-Select; ENST00000311507.9; ENSP00000309509.4; NM_016619.3; NP_057703.1.
DR CTD; 51316; -.
DR DisGeNET; 51316; -.
DR GeneCards; PLAC8; -.
DR HGNC; HGNC:19254; PLAC8.
DR HPA; ENSG00000145287; Group enriched (bone marrow, esophagus, intestine, lymphoid tissue, stomach).
DR MIM; 607515; gene.
DR neXtProt; NX_Q9NZF1; -.
DR OpenTargets; ENSG00000145287; -.
DR PharmGKB; PA134950814; -.
DR VEuPathDB; HostDB:ENSG00000145287; -.
DR eggNOG; ENOG502S3TI; Eukaryota.
DR GeneTree; ENSGT00940000157329; -.
DR HOGENOM; CLU_083147_5_2_1; -.
DR InParanoid; Q9NZF1; -.
DR OMA; RKQQGIF; -.
DR OrthoDB; 1354725at2759; -.
DR PhylomeDB; Q9NZF1; -.
DR TreeFam; TF330308; -.
DR PathwayCommons; Q9NZF1; -.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR SignaLink; Q9NZF1; -.
DR BioGRID-ORCS; 51316; 14 hits in 1065 CRISPR screens.
DR ChiTaRS; PLAC8; human.
DR GenomeRNAi; 51316; -.
DR Pharos; Q9NZF1; Tbio.
DR PRO; PR:Q9NZF1; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q9NZF1; protein.
DR Bgee; ENSG00000145287; Expressed in bronchial epithelial cell and 146 other tissues.
DR ExpressionAtlas; Q9NZF1; baseline and differential.
DR Genevisible; Q9NZF1; HS.
DR GO; GO:0035578; C:azurophil granule lumen; TAS:Reactome.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0040015; P:negative regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; ISS:YuBioLab.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0009409; P:response to cold; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR InterPro; IPR006461; PLAC_motif_containing.
DR PANTHER; PTHR15907; PTHR15907; 1.
DR Pfam; PF04749; PLAC8; 1.
DR TIGRFAMs; TIGR01571; A_thal_Cys_rich; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..115
FT /note="Placenta-specific gene 8 protein"
FT /id="PRO_0000186092"
SQ SEQUENCE 115 AA; 12507 MW; 24B6D7940390C6BF CRC64;
MQAQAPVVVV TQPGVGPGPA PQNSNWQTGM CDCFSDCGVC LCGTFCFPCL GCQVAADMNE
CCLCGTSVAM RTLYRTRYGI PGSICDDYMA TLCCPHCTLC QIKRDINRRR AMRTF
