ID   PLAC8_MOUSE             Reviewed;         112 AA.
AC   Q9JI48;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Placenta-specific gene 8 protein;
DE   AltName: Full=Onzin;
DE   AltName: Full=Protein C15;
GN   Name=Plac8;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Sherwin J.R.A., Sharkey A.M., Smith S.K.;
RT   "Identification of LIF regulated genes in the mouse uterus.";
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12384430; DOI=10.1182/blood-2002-02-0638;
RA   Rissoan M.-C., Duhen T., Bridon J.-M., Bendriss-Vermare N., Peronne C.,
RA   de Saint-Vis B.M., Briere F., Bates E.E.M.;
RT   "Subtractive hybridization reveals the expression of immunoglobulin like
RT   transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human
RT   plasmacytoid dendritic cells.";
RL   Blood 100:3295-3303(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Pancreas;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, Liver, Lung, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the cornifelin family. {ECO:0000305}.
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DR   EMBL; AF263458; AAF76887.1; -; mRNA.
DR   EMBL; AJ422151; CAD19534.1; -; mRNA.
DR   EMBL; AK007369; BAB24991.1; -; mRNA.
DR   EMBL; BC010789; AAH10789.1; -; mRNA.
DR   CCDS; CCDS19464.1; -.
DR   RefSeq; NP_631937.1; NM_139198.2.
DR   RefSeq; XP_011247732.1; XM_011249430.1.
DR   AlphaFoldDB; Q9JI48; -.
DR   BioGRID; 231130; 1.
DR   IntAct; Q9JI48; 1.
DR   STRING; 10090.ENSMUSP00000031264; -.
DR   PhosphoSitePlus; Q9JI48; -.
DR   EPD; Q9JI48; -.
DR   jPOST; Q9JI48; -.
DR   MaxQB; Q9JI48; -.
DR   PaxDb; Q9JI48; -.
DR   PRIDE; Q9JI48; -.
DR   ProteomicsDB; 289668; -.
DR   Antibodypedia; 52449; 72 antibodies from 18 providers.
DR   DNASU; 231507; -.
DR   Ensembl; ENSMUST00000031264; ENSMUSP00000031264; ENSMUSG00000029322.
DR   Ensembl; ENSMUST00000097437; ENSMUSP00000108533; ENSMUSG00000029322.
DR   Ensembl; ENSMUST00000112910; ENSMUSP00000108531; ENSMUSG00000029322.
DR   GeneID; 231507; -.
DR   KEGG; mmu:231507; -.
DR   UCSC; uc008yht.1; mouse.
DR   CTD; 51316; -.
DR   MGI; MGI:2445289; Plac8.
DR   VEuPathDB; HostDB:ENSMUSG00000029322; -.
DR   eggNOG; ENOG502S3TI; Eukaryota.
DR   GeneTree; ENSGT00940000157329; -.
DR   HOGENOM; CLU_083147_5_3_1; -.
DR   InParanoid; Q9JI48; -.
DR   OMA; RKQQGIF; -.
DR   PhylomeDB; Q9JI48; -.
DR   TreeFam; TF330308; -.
DR   Reactome; R-MMU-6798695; Neutrophil degranulation.
DR   BioGRID-ORCS; 231507; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; Plac8; mouse.
DR   PRO; PR:Q9JI48; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q9JI48; protein.
DR   Bgee; ENSMUSG00000029322; Expressed in gastrula and 179 other tissues.
DR   Genevisible; Q9JI48; MM.
DR   GO; GO:0005634; C:nucleus; IC:MGI.
DR   GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR   GO; GO:0050873; P:brown fat cell differentiation; IMP:MGI.
DR   GO; GO:0042742; P:defense response to bacterium; IMP:MGI.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
DR   GO; GO:0040015; P:negative regulation of multicellular organism growth; IMP:MGI.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:MGI.
DR   GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IMP:YuBioLab.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0009409; P:response to cold; IMP:MGI.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IDA:MGI.
DR   InterPro; IPR006461; PLAC_motif_containing.
DR   PANTHER; PTHR15907; PTHR15907; 1.
DR   Pfam; PF04749; PLAC8; 1.
DR   TIGRFAMs; TIGR01571; A_thal_Cys_rich; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..112
FT                   /note="Placenta-specific gene 8 protein"
FT                   /id="PRO_0000186093"
SQ   SEQUENCE   112 AA;  12353 MW;  4FFBD5E8D91F0DA8 CRC64;
     MAQAPTVIVT QPGFVRAPQN SNWQTSLCDC FSDCGVCLCG TFCFTCLGCQ VAADMNECCL
     CGTTVAMRTL YRTRYGIPGS ICDDYMVTLF CPVCSVCQLK RDINRRRAMN AF