PLAC9_HUMAN
ID PLAC9_HUMAN Reviewed; 97 AA.
AC Q5JTB6;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Placenta-specific protein 9;
DE Flags: Precursor;
GN Name=PLAC9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5JTB6; Q9Y6C2: EMILIN1; NbExp=5; IntAct=EBI-3923605, EBI-744586;
CC Q5JTB6; Q9Y6C2-2: EMILIN1; NbExp=7; IntAct=EBI-3923605, EBI-11748557;
CC Q5JTB6; Q96D09: GPRASP2; NbExp=3; IntAct=EBI-3923605, EBI-473189;
CC Q5JTB6; O95295: SNAPIN; NbExp=3; IntAct=EBI-3923605, EBI-296723;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PLAC9 family. {ECO:0000305}.
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DR EMBL; AL356095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC066348; AAH66348.1; -; mRNA.
DR EMBL; BC090922; AAH90922.1; -; mRNA.
DR EMBL; BC117332; AAI17333.1; -; mRNA.
DR EMBL; BC117334; AAI17335.1; -; mRNA.
DR CCDS; CCDS31232.1; -.
DR RefSeq; NP_001012991.1; NM_001012973.1.
DR RefSeq; NP_001318054.1; NM_001331125.1.
DR AlphaFoldDB; Q5JTB6; -.
DR SMR; Q5JTB6; -.
DR BioGRID; 128524; 27.
DR IntAct; Q5JTB6; 6.
DR STRING; 9606.ENSP00000361337; -.
DR GlyGen; Q5JTB6; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5JTB6; -.
DR PhosphoSitePlus; Q5JTB6; -.
DR BioMuta; PLAC9; -.
DR jPOST; Q5JTB6; -.
DR MassIVE; Q5JTB6; -.
DR PaxDb; Q5JTB6; -.
DR PeptideAtlas; Q5JTB6; -.
DR PRIDE; Q5JTB6; -.
DR ProteomicsDB; 63208; -.
DR Antibodypedia; 29944; 87 antibodies from 20 providers.
DR DNASU; 219348; -.
DR Ensembl; ENST00000372263.4; ENSP00000361337.3; ENSG00000189129.14.
DR GeneID; 219348; -.
DR KEGG; hsa:219348; -.
DR MANE-Select; ENST00000372263.4; ENSP00000361337.3; NM_001012973.3; NP_001012991.1.
DR UCSC; uc001kbp.2; human.
DR CTD; 219348; -.
DR GeneCards; PLAC9; -.
DR HGNC; HGNC:19255; PLAC9.
DR HPA; ENSG00000189129; Low tissue specificity.
DR MIM; 612857; gene.
DR neXtProt; NX_Q5JTB6; -.
DR OpenTargets; ENSG00000189129; -.
DR PharmGKB; PA134941839; -.
DR VEuPathDB; HostDB:ENSG00000189129; -.
DR eggNOG; ENOG502SEJ6; Eukaryota.
DR GeneTree; ENSGT00390000017848; -.
DR HOGENOM; CLU_171497_0_0_1; -.
DR InParanoid; Q5JTB6; -.
DR OMA; PAWSTGC; -.
DR OrthoDB; 1597730at2759; -.
DR PhylomeDB; Q5JTB6; -.
DR TreeFam; TF338208; -.
DR PathwayCommons; Q5JTB6; -.
DR SignaLink; Q5JTB6; -.
DR BioGRID-ORCS; 219348; 46 hits in 1058 CRISPR screens.
DR GenomeRNAi; 219348; -.
DR Pharos; Q5JTB6; Tdark.
DR PRO; PR:Q5JTB6; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5JTB6; protein.
DR Bgee; ENSG00000189129; Expressed in layer of synovial tissue and 143 other tissues.
DR ExpressionAtlas; Q5JTB6; baseline and differential.
DR Genevisible; Q5JTB6; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR027941; PLAC9.
DR PANTHER; PTHR37355; PTHR37355; 1.
DR Pfam; PF15205; PLAC9; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..97
FT /note="Placenta-specific protein 9"
FT /id="PRO_0000261405"
SQ SEQUENCE 97 AA; 10309 MW; 02B112554401952F CRC64;
MRPLLCALTG LALLRAAGSL AAAEPFSPPR GDSAQSTACD RHMAVQRRLD VMEEMVEKTV
DHLGTEVKGL LGLLEELAWN LPPGPFSPAP DLLGDGF
