PLAC9_MOUSE
ID PLAC9_MOUSE Reviewed; 108 AA.
AC Q8K262; Q3V2D9;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Placenta-specific protein 9;
DE Flags: Precursor;
GN Name=Plac9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Head, Tongue, and Xiphoid cartilage;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=12758124; DOI=10.1016/s0378-1119(03)00508-0;
RA Galaviz-Hernandez C., Stagg C., de Ridder G., Tanaka T.S., Ko M.S.,
RA Schlessinger D., Nagaraja R.;
RT "Plac8 and Plac9, novel placental-enriched genes identified through
RT microarray analysis.";
RL Gene 309:81-89(2003).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Highly expressed in placenta, and weakly in ovary,
CC testis, and lung. {ECO:0000269|PubMed:12758124}.
CC -!- SIMILARITY: Belongs to the PLAC9 family. {ECO:0000305}.
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DR EMBL; AK028003; BAE20434.1; -; mRNA.
DR EMBL; AK047878; BAE20662.1; -; mRNA.
DR EMBL; AK131614; BAE20721.1; -; mRNA.
DR EMBL; AK131901; BAE20859.1; -; mRNA.
DR EMBL; AK133546; BAE21717.1; -; mRNA.
DR EMBL; AK160781; BAE36005.1; -; mRNA.
DR EMBL; BC032982; AAH32982.1; -; mRNA.
DR CCDS; CCDS36832.1; -.
DR RefSeq; NP_001257432.1; NM_001270503.1.
DR RefSeq; NP_997112.1; NM_207229.1.
DR RefSeq; XP_001472444.1; XM_001472394.7.
DR AlphaFoldDB; Q8K262; -.
DR SMR; Q8K262; -.
DR STRING; 10090.ENSMUSP00000056665; -.
DR PhosphoSitePlus; Q8K262; -.
DR MaxQB; Q8K262; -.
DR PaxDb; Q8K262; -.
DR PRIDE; Q8K262; -.
DR Antibodypedia; 29944; 87 antibodies from 20 providers.
DR Ensembl; ENSMUST00000052286; ENSMUSP00000056665; ENSMUSG00000095304.
DR GeneID; 211623; -.
DR KEGG; mmu:211623; -.
DR UCSC; uc007srw.2; mouse.
DR CTD; 219348; -.
DR MGI; MGI:2663998; Plac9.
DR VEuPathDB; HostDB:ENSMUSG00000072674; -.
DR VEuPathDB; HostDB:ENSMUSG00000094800; -.
DR VEuPathDB; HostDB:ENSMUSG00000095304; -.
DR eggNOG; ENOG502SEJ6; Eukaryota.
DR GeneTree; ENSGT00390000017848; -.
DR HOGENOM; CLU_171497_0_0_1; -.
DR InParanoid; Q8K262; -.
DR OMA; SPGCDRH; -.
DR OrthoDB; 1558775at2759; -.
DR PhylomeDB; Q8K262; -.
DR TreeFam; TF338208; -.
DR BioGRID-ORCS; 100039175; 0 hits in 1 CRISPR screen.
DR BioGRID-ORCS; 100039246; 3 hits in 31 CRISPR screens.
DR BioGRID-ORCS; 211623; 1 hit in 29 CRISPR screens.
DR ChiTaRS; Gm9780; mouse.
DR PRO; PR:Q8K262; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8K262; protein.
DR Bgee; ENSMUSG00000095304; Expressed in esophagus and 60 other tissues.
DR ExpressionAtlas; Q8K262; differential.
DR Genevisible; Q8K262; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR027941; PLAC9.
DR PANTHER; PTHR37355; PTHR37355; 1.
DR Pfam; PF15205; PLAC9; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..108
FT /note="Placenta-specific protein 9"
FT /id="PRO_0000261406"
FT REGION 18..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 54..91
FT /evidence="ECO:0000255"
SQ SEQUENCE 108 AA; 11275 MW; 7B91B57F1ED613F9 CRC64;
MQALLCALAG LALLRAGTGE WGQGPRDTPG RRAAESPSSP GDLAGSPGCD RHAAVQRRLD
IMEETVEKTV EHLEAEVTGL LGLLEELASN LPTGPFSPKP DLLGDDGF
