PLAG1_CHICK
ID PLAG1_CHICK Reviewed; 501 AA.
AC Q58NQ5;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Zinc finger protein PLAG1;
DE AltName: Full=Pleiomorphic adenoma gene 1 protein;
GN Name=PLAG1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=16397219; DOI=10.1158/0008-5472.can-05-1728;
RA Pajer P., Pecenka V., Kralova J., Karafiat V., Prukova D., Zemanova Z.,
RA Kodet R., Dvorak M.;
RT "Identification of potential human oncogenes by mapping the common viral
RT integration sites in avian nephroblastoma.";
RL Cancer Res. 66:78-86(2006).
CC -!- FUNCTION: Transcription factor and proto-oncogene whose activation
CC results in up-regulation of target genes, such as IGFII, leading to
CC uncontrolled cell proliferation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in nephroblastoma.
CC {ECO:0000269|PubMed:16397219}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AY935990; AAX36028.1; -; mRNA.
DR RefSeq; NP_001026748.1; NM_001031577.1.
DR RefSeq; XP_015138164.1; XM_015282678.1.
DR AlphaFoldDB; Q58NQ5; -.
DR SMR; Q58NQ5; -.
DR STRING; 9031.ENSGALP00000024806; -.
DR PaxDb; Q58NQ5; -.
DR PRIDE; Q58NQ5; -.
DR Ensembl; ENSGALT00000024852; ENSGALP00000024806; ENSGALG00000015407.
DR Ensembl; ENSGALT00000107668; ENSGALP00000066771; ENSGALG00000015407.
DR GeneID; 429484; -.
DR KEGG; gga:429484; -.
DR CTD; 5324; -.
DR VEuPathDB; HostDB:geneid_429484; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000159246; -.
DR HOGENOM; CLU_002678_66_1_1; -.
DR InParanoid; Q58NQ5; -.
DR OMA; GTENRHD; -.
DR OrthoDB; 615178at2759; -.
DR PhylomeDB; Q58NQ5; -.
DR TreeFam; TF332024; -.
DR PRO; PR:Q58NQ5; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000015407; Expressed in lung and 11 other tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0022612; P:gland morphogenesis; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0060252; P:positive regulation of glial cell proliferation; IEA:Ensembl.
DR GO; GO:0060736; P:prostate gland growth; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR027765; PLAG1/PLAGL2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24390:SF64; PTHR24390:SF64; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Proto-oncogene;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..501
FT /note="Zinc finger protein PLAG1"
FT /id="PRO_0000295110"
FT ZN_FING 34..56
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 62..86
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 92..114
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 121..143
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 150..172
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 185..207
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 213..236
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 22..25
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 366..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 501 AA; 55958 MW; EB4E7A4AE8DB1E1A CRC64;
MATVIPGDLS EVRDTQKVPS GKRKRGETKP RKNFPCQLCD KAFNSVEKLK VHSYSHTGER
PYKCTQQDCT KAFVSKYKLL RHMATHSPEK THKCNYCEKM FHRKDHLKNH LHTHNPNKEA
FKCEECGKNY NTKLGFKRHL ALHAATSGDL TCKVCLQTFE STGVLLEHLK THAGKSSGGV
KEKKHQCEHC DRRFYTRKDV RRHMVVHTGR KDFLCQYCAQ RFGRKDHLTR HMKKSHNQEL
LKVKTEPMDL LDPFTCNVSV PIKDELLPVM SLPSSELTSK PFTNTLQLNL YNTQIQSMQS
SASAHQMVAT SLPLGMPCPI DMESVHPSHQ LSLKYPLSST SYAVSMPEKE QPLKGEIESY
LMELQSGMPS SSQDSQASSS KLGLDPQVGP LDDGSGEVSL SKGSVPISEP LNTPSLDFSQ
LFNFIPVNGP PYNPSVSVGN LGMSYTQEEA HSSMTQLPPQ TQDPQDPSNS IGLGSLHSLS
AAFTSSLSTT TTLPRFHQAF Q
