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PLAL1_HUMAN
ID   PLAL1_HUMAN             Reviewed;         463 AA.
AC   Q9UM63; B2RBA4; B2RCM8; E1P595; E1P597; O76019; Q7Z3V8; Q92981; Q96JR9;
AC   Q9UIZ0;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   03-AUG-2022, entry version 186.
DE   RecName: Full=Zinc finger protein PLAGL1;
DE   AltName: Full=Lost on transformation 1;
DE            Short=LOT-1;
DE   AltName: Full=Pleiomorphic adenoma-like protein 1;
DE   AltName: Full=Tumor suppressor ZAC;
GN   Name=PLAGL1; Synonyms=LOT1, ZAC;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=9150364; DOI=10.1038/sj.onc.1201034;
RA   Abdollahi A., Roberts D., Godwin A.K., Schultz D.C., Sonoda G., Testa J.R.,
RA   Hamilton T.C.;
RT   "Identification of a zinc-finger gene at 6q25: a chromosomal region
RT   implicated in development of many solid tumors.";
RL   Oncogene 14:1973-1979(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND FUNCTION.
RX   PubMed=9722527; DOI=10.1074/jbc.273.36.23026;
RA   Kas K., Voz M.L., Hensen K., Meyen E., Van de Ven W.J.M.;
RT   "Transcriptional activation capacity of the novel PLAG family of zinc
RT   finger proteins.";
RL   J. Biol. Chem. 273:23026-23032(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Pituitary;
RX   PubMed=9671765; DOI=10.1073/pnas.95.15.8835;
RA   Varrault A., Ciani E., Apiou F., Bilanges B., Hoffmann A., Pantaloni C.,
RA   Bockaert J., Spengler D., Journot L.;
RT   "hZAC encodes a zinc finger protein with antiproliferative properties and
RT   maps to a chromosomal region frequently lost in cancer.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:8835-8840(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND SUBCELLULAR LOCATION.
RC   TISSUE=Mammary gland;
RX   PubMed=11313869; DOI=10.1038/sj.onc.1204237;
RA   Bilanges B., Varrault A., Mazumdar A., Pantaloni C., Hoffmann A.,
RA   Bockaert J., Spengler D., Journot L.;
RT   "Alternative splicing of the imprinted candidate tumor suppressor gene ZAC
RT   regulates its antiproliferative and DNA binding activities.";
RL   Oncogene 20:1246-1253(2001).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Placenta;
RA   Varrault A., Bilanges B., Mackay D.J., Basyuk E., Ahr B., Fernandez C.,
RA   Robinson D.O., Bockaert J., Journot L.;
RT   "Characterization of the methylation-sensitive promoter of the imprinted
RT   ZAC (PLAGL1) gene supports its role in transient neonatal diabetes
RT   mellitus.";
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Colon;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Fetal kidney;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [11]
RP   INVOLVEMENT IN TNDM1.
RX   PubMed=11935319; DOI=10.1007/s00439-001-0671-5;
RA   Mackay D.J., Coupe A.M., Shield J.P., Storr J.N., Temple I.K.,
RA   Robinson D.O.;
RT   "Relaxation of imprinted expression of ZAC and HYMAI in a patient with
RT   transient neonatal diabetes mellitus.";
RL   Hum. Genet. 110:139-144(2002).
RN   [12]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH THRSP.
RX   PubMed=18299245; DOI=10.1016/j.biocel.2008.01.014;
RA   Chou W.Y., Ho C.L., Tseng M.L., Liu S.T., Yen L.C., Huang S.M.;
RT   "Human Spot 14 protein is a p53-dependent transcriptional coactivator via
RT   the recruitment of thyroid receptor and Zac1.";
RL   Int. J. Biochem. Cell Biol. 40:1826-1834(2008).
RN   [13]
RP   INVOLVEMENT IN TNDM1.
RX   PubMed=18622393; DOI=10.1038/ng.187;
RA   Mackay D.J.G., Callaway J.L.A., Marks S.M., White H.E., Acerini C.L.,
RA   Boonen S.E., Dayanikli P., Firth H.V., Goodship J.A., Haemers A.P.,
RA   Hahnemann J.M.D., Kordonouri O., Masoud A.F., Oestergaard E., Storr J.,
RA   Ellard S., Hattersley A.T., Robinson D.O., Temple I.K.;
RT   "Hypomethylation of multiple imprinted loci in individuals with transient
RT   neonatal diabetes is associated with mutations in ZFP57.";
RL   Nat. Genet. 40:949-951(2008).
CC   -!- FUNCTION: Acts as a transcriptional activator (PubMed:9722527).
CC       Involved in the transcriptional regulation of type 1 receptor for
CC       pituitary adenylate cyclase-activating polypeptide.
CC       {ECO:0000269|PubMed:18299245, ECO:0000269|PubMed:9722527}.
CC   -!- SUBUNIT: Interacts with THRSP. {ECO:0000269|PubMed:18299245}.
CC   -!- INTERACTION:
CC       Q9UM63; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-7233410, EBI-2556193;
CC       Q9UM63; Q08117-2: TLE5; NbExp=3; IntAct=EBI-7233410, EBI-11741437;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11313869,
CC       ECO:0000269|PubMed:18299245}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9UM63-1; Sequence=Displayed;
CC       Name=2; Synonyms=ZACdelta2;
CC         IsoId=Q9UM63-2; Sequence=VSP_028123;
CC   -!- DISEASE: Diabetes mellitus, transient neonatal, 1 (TNDM1) [MIM:601410]:
CC       An autosomal dominant form of diabetes mellitus defined by the onset of
CC       mild-to-severe hyperglycemia within the first month of life. In about
CC       half of the neonates, diabetes is transient and resolves at a median
CC       age of 3 months, whereas the rest have a permanent form of diabetes.
CC       {ECO:0000269|PubMed:11935319}. Note=The gene represented in this entry
CC       is involved in disease pathogenesis. Imprinted expression of PLAGL1 is
CC       relaxed in patients with transient neonatal diabetes (TND)
CC       (PubMed:11935319). Aberrant hypomethylation of the TND differentially
CC       methylated region within the PLAGL1 promoter as well as other imprinted
CC       loci at chromosome 6q24 is caused by ZFP57 mutations (PubMed:18622393).
CC       {ECO:0000269|PubMed:11935319, ECO:0000269|PubMed:18622393}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC       Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/PLAGL1ID41737ch6q24.html";
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DR   EMBL; U72621; AAB67041.1; -; mRNA.
DR   EMBL; U81992; AAC34250.1; -; mRNA.
DR   EMBL; AJ006354; CAA06994.1; -; mRNA.
DR   EMBL; AJ303119; CAC39614.1; -; mRNA.
DR   EMBL; AJ311395; CAC39615.1; -; mRNA.
DR   EMBL; AK314570; BAG37151.1; -; mRNA.
DR   EMBL; AK315184; BAG37625.1; -; mRNA.
DR   EMBL; BX537397; CAD97639.1; -; mRNA.
DR   EMBL; AL049844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471051; EAW47852.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW47853.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW47854.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW47855.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW47856.1; -; Genomic_DNA.
DR   EMBL; BC074814; AAH74814.1; -; mRNA.
DR   EMBL; BC109085; AAI09086.1; -; mRNA.
DR   EMBL; BC109086; AAI09087.1; -; mRNA.
DR   CCDS; CCDS5202.1; -. [Q9UM63-1]
DR   CCDS; CCDS5203.1; -. [Q9UM63-2]
DR   RefSeq; NP_001074420.1; NM_001080951.2. [Q9UM63-1]
DR   RefSeq; NP_001074421.1; NM_001080952.2. [Q9UM63-1]
DR   RefSeq; NP_001074422.1; NM_001080953.2. [Q9UM63-1]
DR   RefSeq; NP_001074423.1; NM_001080954.2. [Q9UM63-1]
DR   RefSeq; NP_001074424.1; NM_001080955.2. [Q9UM63-2]
DR   RefSeq; NP_001074425.1; NM_001080956.2. [Q9UM63-2]
DR   RefSeq; NP_001275966.1; NM_001289037.1. [Q9UM63-2]
DR   RefSeq; NP_001275967.1; NM_001289038.1. [Q9UM63-2]
DR   RefSeq; NP_001275968.1; NM_001289039.1. [Q9UM63-2]
DR   RefSeq; NP_001275969.1; NM_001289040.1. [Q9UM63-2]
DR   RefSeq; NP_001275970.1; NM_001289041.1. [Q9UM63-2]
DR   RefSeq; NP_001275971.1; NM_001289042.1. [Q9UM63-1]
DR   RefSeq; NP_001275972.1; NM_001289043.1. [Q9UM63-1]
DR   RefSeq; NP_001275973.1; NM_001289044.1. [Q9UM63-1]
DR   RefSeq; NP_001275974.1; NM_001289045.1. [Q9UM63-1]
DR   RefSeq; NP_001275975.1; NM_001289046.1. [Q9UM63-1]
DR   RefSeq; NP_001275976.1; NM_001289047.1. [Q9UM63-1]
DR   RefSeq; NP_001275977.1; NM_001289048.1. [Q9UM63-1]
DR   RefSeq; NP_001275978.1; NM_001289049.1. [Q9UM63-1]
DR   RefSeq; NP_001304085.1; NM_001317156.1. [Q9UM63-1]
DR   RefSeq; NP_001304086.1; NM_001317157.1. [Q9UM63-1]
DR   RefSeq; NP_001304087.1; NM_001317158.1. [Q9UM63-2]
DR   RefSeq; NP_001304088.1; NM_001317159.1. [Q9UM63-1]
DR   RefSeq; NP_001304089.1; NM_001317160.1. [Q9UM63-2]
DR   RefSeq; NP_001304090.1; NM_001317161.1. [Q9UM63-1]
DR   RefSeq; NP_001304091.1; NM_001317162.1. [Q9UM63-1]
DR   RefSeq; NP_006709.2; NM_006718.4. [Q9UM63-1]
DR   AlphaFoldDB; Q9UM63; -.
DR   SMR; Q9UM63; -.
DR   BioGRID; 111341; 15.
DR   IntAct; Q9UM63; 3.
DR   MINT; Q9UM63; -.
DR   STRING; 9606.ENSP00000353734; -.
DR   iPTMnet; Q9UM63; -.
DR   PhosphoSitePlus; Q9UM63; -.
DR   BioMuta; PLAGL1; -.
DR   DMDM; 158523334; -.
DR   EPD; Q9UM63; -.
DR   jPOST; Q9UM63; -.
DR   MassIVE; Q9UM63; -.
DR   MaxQB; Q9UM63; -.
DR   PaxDb; Q9UM63; -.
DR   PeptideAtlas; Q9UM63; -.
DR   PRIDE; Q9UM63; -.
DR   ProteomicsDB; 85183; -. [Q9UM63-1]
DR   ProteomicsDB; 85184; -. [Q9UM63-2]
DR   Antibodypedia; 19825; 236 antibodies from 30 providers.
DR   DNASU; 5325; -.
DR   Ensembl; ENST00000354765.6; ENSP00000346810.2; ENSG00000118495.21. [Q9UM63-1]
DR   Ensembl; ENST00000360537.6; ENSP00000353734.2; ENSG00000118495.21. [Q9UM63-1]
DR   Ensembl; ENST00000367571.3; ENSP00000356543.1; ENSG00000118495.21. [Q9UM63-1]
DR   Ensembl; ENST00000367572.3; ENSP00000356544.1; ENSG00000118495.21. [Q9UM63-2]
DR   Ensembl; ENST00000416623.5; ENSP00000400060.1; ENSG00000118495.21. [Q9UM63-1]
DR   Ensembl; ENST00000417959.4; ENSP00000395960.2; ENSG00000118495.21. [Q9UM63-2]
DR   Ensembl; ENST00000437412.5; ENSP00000392418.1; ENSG00000118495.21. [Q9UM63-2]
DR   Ensembl; ENST00000444202.5; ENSP00000400929.1; ENSG00000118495.21. [Q9UM63-1]
DR   Ensembl; ENST00000625622.2; ENSP00000486355.1; ENSG00000118495.21. [Q9UM63-1]
DR   Ensembl; ENST00000647880.1; ENSP00000496815.1; ENSG00000118495.21. [Q9UM63-2]
DR   Ensembl; ENST00000649211.1; ENSP00000497492.1; ENSG00000118495.21. [Q9UM63-1]
DR   Ensembl; ENST00000649307.1; ENSP00000496979.1; ENSG00000118495.21. [Q9UM63-1]
DR   Ensembl; ENST00000650125.1; ENSP00000497363.1; ENSG00000118495.21. [Q9UM63-1]
DR   Ensembl; ENST00000674357.1; ENSP00000501459.1; ENSG00000118495.21. [Q9UM63-1]
DR   GeneID; 5325; -.
DR   KEGG; hsa:5325; -.
DR   MANE-Select; ENST00000674357.1; ENSP00000501459.1; NM_001317162.2; NP_001304091.1.
DR   UCSC; uc003qjv.4; human. [Q9UM63-1]
DR   CTD; 5325; -.
DR   DisGeNET; 5325; -.
DR   GeneCards; PLAGL1; -.
DR   GeneReviews; PLAGL1; -.
DR   HGNC; HGNC:9046; PLAGL1.
DR   HPA; ENSG00000118495; Tissue enhanced (placenta).
DR   MalaCards; PLAGL1; -.
DR   MIM; 601410; phenotype.
DR   MIM; 603044; gene.
DR   neXtProt; NX_Q9UM63; -.
DR   OpenTargets; ENSG00000118495; -.
DR   Orphanet; 96191; Paternal uniparental disomy of chromosome 6.
DR   Orphanet; 99886; Transient neonatal diabetes mellitus.
DR   PharmGKB; PA33379; -.
DR   VEuPathDB; HostDB:ENSG00000118495; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000162004; -.
DR   HOGENOM; CLU_002678_66_1_1; -.
DR   InParanoid; Q9UM63; -.
DR   OMA; ITMAFGP; -.
DR   PhylomeDB; Q9UM63; -.
DR   TreeFam; TF332024; -.
DR   PathwayCommons; Q9UM63; -.
DR   Reactome; R-HSA-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR   SignaLink; Q9UM63; -.
DR   SIGNOR; Q9UM63; -.
DR   BioGRID-ORCS; 5325; 13 hits in 1100 CRISPR screens.
DR   ChiTaRS; PLAGL1; human.
DR   GeneWiki; PLAGL1; -.
DR   GenomeRNAi; 5325; -.
DR   Pharos; Q9UM63; Tbio.
DR   PRO; PR:Q9UM63; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q9UM63; protein.
DR   Bgee; ENSG00000118495; Expressed in adrenal tissue and 196 other tissues.
DR   ExpressionAtlas; Q9UM63; baseline and differential.
DR   Genevisible; Q9UM63; HS.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0016604; C:nuclear body; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IDA:MGI.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:0006915; P:apoptotic process; TAS:ProtInc.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR   GO; GO:0051726; P:regulation of cell cycle; TAS:ProtInc.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR027770; PLAGL1.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24399:SF31; PTHR24399:SF31; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 7.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE   1: Evidence at protein level;
KW   Activator; Alternative splicing; Diabetes mellitus; DNA-binding;
KW   Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..463
FT                   /note="Zinc finger protein PLAGL1"
FT                   /id="PRO_0000047222"
FT   ZN_FING         4..26
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         32..56
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         62..84
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         91..113
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         120..142
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         156..178
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         184..207
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          268..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..52
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11313869,
FT                   ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:17974005,
FT                   ECO:0000303|PubMed:9722527"
FT                   /id="VSP_028123"
FT   VARIANT         272
FT                   /note="A -> V (in dbSNP:rs35263016)"
FT                   /id="VAR_052729"
FT   CONFLICT        81
FT                   /note="L -> F (in Ref. 1; AAB67041)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        197
FT                   /note="D -> V (in Ref. 2; AAC34250)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   463 AA;  50819 MW;  B10C74DA409BD4F7 CRC64;
     MATFPCQLCG KTFLTLEKFT IHNYSHSRER PYKCVQPDCG KAFVSRYKLM RHMATHSPQK
     SHQCAHCEKT FNRKDHLKNH LQTHDPNKMA FGCEECGKKY NTMLGYKRHL ALHAASSGDL
     TCGVCALELG STEVLLDHLK AHAEEKPPSG TKEKKHQCDH CERCFYTRKD VRRHLVVHTG
     CKDFLCQFCA QRFGRKDHLT RHTKKTHSQE LMKESLQTGD LLSTFHTISP SFQLKAAALP
     PFPLGASAQN GLASSLPAEV HSLTLSPPEQ AAQPMQPLPE SLASLHPSVS PGSPPPPLPN
     HKYNTTSTSY SPLASLPLKA DTKGFCNISL FEDLPLQEPQ SPQKLNPGFD LAKGNAGKVN
     LPKELPADAV NLTIPASLDL SPLLGFWQLP PPATQNTFGN STLALGPGES LPHRLSCLGQ
     QQQEPPLAMG TVSLGQLPLP PIPHVFSAGT GSAILPHFHH AFR
 
 
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