PLAL1_PIG
ID PLAL1_PIG Reviewed; 463 AA.
AC Q2I689;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Zinc finger protein PLAGL1;
DE AltName: Full=Pleiomorphic adenoma-like protein 1;
GN Name=PLAGL1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=17178803; DOI=10.2527/jas.2006-278;
RA Zhang F.W., Cheng H.C., Jiang C.D., Deng C.Y., Xiong Y.Z., Li F.E.,
RA Lei M.G.;
RT "Imprinted status of pleomorphic adenoma gene-like I and paternal
RT expression gene 10 genes in pigs.";
RL J. Anim. Sci. 85:886-890(2007).
CC -!- FUNCTION: Acts as a transcriptional activator. Involved in the
CC transcriptional regulation of type 1 receptor for pituitary adenylate
CC cyclase-activating polypeptide. {ECO:0000250|UniProtKB:Q9UM63}.
CC -!- SUBUNIT: Interacts with THRSP. {ECO:0000250|UniProtKB:Q9UM63}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UM63}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; DQ288899; ABB90556.1; -; mRNA.
DR RefSeq; NP_001038010.1; NM_001044545.1.
DR RefSeq; XP_005654425.1; XM_005654368.2.
DR RefSeq; XP_005654426.1; XM_005654369.2.
DR RefSeq; XP_005654427.1; XM_005654370.2.
DR RefSeq; XP_005654428.1; XM_005654371.2.
DR RefSeq; XP_005654429.1; XM_005654372.2.
DR RefSeq; XP_005654430.1; XM_005654373.2.
DR RefSeq; XP_013840210.1; XM_013984756.1.
DR RefSeq; XP_013840213.1; XM_013984759.1.
DR RefSeq; XP_013840216.1; XM_013984762.1.
DR RefSeq; XP_013840218.1; XM_013984764.1.
DR RefSeq; XP_013840221.1; XM_013984767.1.
DR RefSeq; XP_013840226.1; XM_013984772.1.
DR AlphaFoldDB; Q2I689; -.
DR SMR; Q2I689; -.
DR STRING; 9823.ENSSSCP00000004459; -.
DR PaxDb; Q2I689; -.
DR PRIDE; Q2I689; -.
DR Ensembl; ENSSSCT00000058859; ENSSSCP00000035313; ENSSSCG00000004127.
DR Ensembl; ENSSSCT00015070041; ENSSSCP00015028002; ENSSSCG00015052051.
DR Ensembl; ENSSSCT00025071306; ENSSSCP00025030868; ENSSSCG00025051938.
DR Ensembl; ENSSSCT00030026092; ENSSSCP00030011662; ENSSSCG00030018879.
DR Ensembl; ENSSSCT00035005258; ENSSSCP00035001821; ENSSSCG00035004204.
DR Ensembl; ENSSSCT00040012589; ENSSSCP00040004733; ENSSSCG00040009689.
DR Ensembl; ENSSSCT00045027447; ENSSSCP00045018963; ENSSSCG00045016133.
DR Ensembl; ENSSSCT00050048942; ENSSSCP00050020404; ENSSSCG00050036388.
DR Ensembl; ENSSSCT00055049793; ENSSSCP00055039787; ENSSSCG00055025175.
DR Ensembl; ENSSSCT00060095523; ENSSSCP00060041319; ENSSSCG00060069862.
DR Ensembl; ENSSSCT00065100194; ENSSSCP00065044023; ENSSSCG00065072872.
DR Ensembl; ENSSSCT00065100279; ENSSSCP00065044071; ENSSSCG00065072872.
DR Ensembl; ENSSSCT00065100294; ENSSSCP00065044077; ENSSSCG00065072872.
DR Ensembl; ENSSSCT00065100299; ENSSSCP00065044082; ENSSSCG00065072872.
DR Ensembl; ENSSSCT00065100310; ENSSSCP00065044091; ENSSSCG00065072872.
DR Ensembl; ENSSSCT00065100322; ENSSSCP00065044097; ENSSSCG00065072872.
DR Ensembl; ENSSSCT00065100343; ENSSSCP00065044109; ENSSSCG00065072872.
DR Ensembl; ENSSSCT00065100359; ENSSSCP00065044115; ENSSSCG00065072872.
DR Ensembl; ENSSSCT00065100380; ENSSSCP00065044126; ENSSSCG00065072872.
DR GeneID; 733596; -.
DR KEGG; ssc:733596; -.
DR CTD; 5325; -.
DR VGNC; VGNC:91510; PLAGL1.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162004; -.
DR HOGENOM; CLU_002678_66_1_1; -.
DR InParanoid; Q2I689; -.
DR OMA; ITMAFGP; -.
DR OrthoDB; 1318335at2759; -.
DR TreeFam; TF332024; -.
DR Proteomes; UP000008227; Chromosome 1.
DR Proteomes; UP000314985; Unplaced.
DR Bgee; ENSSSCG00000004127; Expressed in pituitary gland and 40 other tissues.
DR ExpressionAtlas; Q2I689; baseline and differential.
DR Genevisible; Q2I689; SS.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR027770; PLAGL1.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24399:SF31; PTHR24399:SF31; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..463
FT /note="Zinc finger protein PLAGL1"
FT /id="PRO_0000304782"
FT ZN_FING 4..26
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 32..56
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 62..84
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 91..113
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 120..142
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 156..178
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 184..207
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 285..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 51058 MW; 6432B4FDA5110A2D CRC64;
MATYPCQLCG KTFLTLEKFT IHNYSHSRER PYKCLQPDCG KAFISRYKLM RHMATHSPQK
SHQCAHCEKT FNRKDHLKNH LQTHDPNKMA FGCEECGKKY NTMLGYKRHL ALHAASSGDL
TCGVCALELG STEVLLDHLK AHAEEKPPSG TKEKKHQCDH CERCFYTRKD VRRHLVVHTG
CKDFLCQFCA QRFGRKDHLT RHTKKTHSQE LMKESLQSGD LLSTFHSISP QFQLKAAPLS
PFPLGAPAQN GLASSLPAEV HSHTHNPSEQ TSQPVQALPE LLAPLHPVAP PTSPPQPLQN
HKYNTSSTSY SPLASLPLKA DTKGFCNTNL LEDLPLQEPQ SPHKLNPGFD LAKGGAGKVN
LPKELPADAV NLTIPASLDL SPLLGFWQLP PPATQNAFGN STLTLGPGES LPHRLSCLGQ
QQQDPSLAMS TMSLGQLPLP PIPHVFPAGT GSAILPHFHH AFR
