PLAL2_HUMAN
ID PLAL2_HUMAN Reviewed; 496 AA.
AC Q9UPG8; A8K8T5; E1P5M3; Q92584;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 183.
DE RecName: Full=Zinc finger protein PLAGL2;
DE AltName: Full=Pleiomorphic adenoma-like protein 2;
GN Name=PLAGL2; Synonyms=KIAA0198;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fetal kidney;
RX PubMed=9722527; DOI=10.1074/jbc.273.36.23026;
RA Kas K., Voz M.L., Hensen K., Meyen E., Van de Ven W.J.M.;
RT "Transcriptional activation capacity of the novel PLAG family of zinc
RT finger proteins.";
RL J. Biol. Chem. 273:23026-23032(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow;
RX PubMed=8724849; DOI=10.1093/dnares/3.1.17;
RA Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.;
RT "Prediction of the coding sequences of unidentified human genes. V. The
RT coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of
RT cDNA clones from human cell line KG-1.";
RL DNA Res. 3:17-24(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=B-cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Shows weak transcriptional activatory activity.
CC -!- INTERACTION:
CC Q9UPG8; X5D778: ANKRD11; NbExp=3; IntAct=EBI-2876622, EBI-17183751;
CC Q9UPG8; Q03989: ARID5A; NbExp=3; IntAct=EBI-2876622, EBI-948603;
CC Q9UPG8; O75934: BCAS2; NbExp=3; IntAct=EBI-2876622, EBI-1050106;
CC Q9UPG8; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-2876622, EBI-744545;
CC Q9UPG8; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-2876622, EBI-744556;
CC Q9UPG8; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-2876622, EBI-11962928;
CC Q9UPG8; Q6P158: DHX57; NbExp=3; IntAct=EBI-2876622, EBI-1051531;
CC Q9UPG8; Q92997: DVL3; NbExp=3; IntAct=EBI-2876622, EBI-739789;
CC Q9UPG8; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-2876622, EBI-7225287;
CC Q9UPG8; Q86UY5: FAM83A; NbExp=5; IntAct=EBI-2876622, EBI-1384254;
CC Q9UPG8; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-2876622, EBI-6658203;
CC Q9UPG8; P55040: GEM; NbExp=3; IntAct=EBI-2876622, EBI-744104;
CC Q9UPG8; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-2876622, EBI-748515;
CC Q9UPG8; Q9NWQ4-1: GPATCH2L; NbExp=3; IntAct=EBI-2876622, EBI-11959863;
CC Q9UPG8; P13807: GYS1; NbExp=3; IntAct=EBI-2876622, EBI-740553;
CC Q9UPG8; Q9C086: INO80B; NbExp=3; IntAct=EBI-2876622, EBI-715611;
CC Q9UPG8; Q9BZI1: IRX2; NbExp=3; IntAct=EBI-2876622, EBI-12166369;
CC Q9UPG8; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-2876622, EBI-2556193;
CC Q9UPG8; Q9UI95: MAD2L2; NbExp=3; IntAct=EBI-2876622, EBI-77889;
CC Q9UPG8; P28482: MAPK1; NbExp=3; IntAct=EBI-2876622, EBI-959949;
CC Q9UPG8; Q8NDC4: MORN4; NbExp=3; IntAct=EBI-2876622, EBI-10269566;
CC Q9UPG8; O43482: OIP5; NbExp=3; IntAct=EBI-2876622, EBI-536879;
CC Q9UPG8; Q7RTU3: OLIG3; NbExp=3; IntAct=EBI-2876622, EBI-10225049;
CC Q9UPG8; P55771: PAX9; NbExp=5; IntAct=EBI-2876622, EBI-12111000;
CC Q9UPG8; B7ZLY0: PHC2; NbExp=3; IntAct=EBI-2876622, EBI-14568740;
CC Q9UPG8; Q13526: PIN1; NbExp=3; IntAct=EBI-2876622, EBI-714158;
CC Q9UPG8; P0CG20: PRR35; NbExp=3; IntAct=EBI-2876622, EBI-11986293;
CC Q9UPG8; O94955: RHOBTB3; NbExp=3; IntAct=EBI-2876622, EBI-2367123;
CC Q9UPG8; Q0D2K3: RIPPLY1; NbExp=5; IntAct=EBI-2876622, EBI-10226430;
CC Q9UPG8; Q96NU1: SAMD11; NbExp=3; IntAct=EBI-2876622, EBI-14067109;
CC Q9UPG8; P49903: SEPHS1; NbExp=3; IntAct=EBI-2876622, EBI-714091;
CC Q9UPG8; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-2876622, EBI-358489;
CC Q9UPG8; Q9BXF9: TEKT3; NbExp=3; IntAct=EBI-2876622, EBI-8644516;
CC Q9UPG8; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-2876622, EBI-750487;
CC Q9UPG8; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-2876622, EBI-3650647;
CC Q9UPG8; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-2876622, EBI-725997;
CC Q9UPG8; Q14119: VEZF1; NbExp=3; IntAct=EBI-2876622, EBI-11980193;
CC Q9UPG8; P62699: YPEL5; NbExp=3; IntAct=EBI-2876622, EBI-11721624;
CC Q9UPG8; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-2876622, EBI-10273713;
CC Q9UPG8; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-2876622, EBI-745520;
CC Q9UPG8; Q96EJ4; NbExp=3; IntAct=EBI-2876622, EBI-750454;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA12113.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/PLAGL2ID41738ch20q11.html";
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DR EMBL; AF006005; AAC34252.1; -; mRNA.
DR EMBL; D83784; BAA12113.1; ALT_INIT; mRNA.
DR EMBL; AK292450; BAF85139.1; -; mRNA.
DR EMBL; AL121897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW76386.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW76387.1; -; Genomic_DNA.
DR EMBL; BC023655; AAH23655.1; -; mRNA.
DR CCDS; CCDS13197.1; -.
DR RefSeq; NP_002648.1; NM_002657.3.
DR RefSeq; XP_005260493.1; XM_005260436.3.
DR RefSeq; XP_011527165.1; XM_011528863.2.
DR RefSeq; XP_011527166.1; XM_011528864.2.
DR AlphaFoldDB; Q9UPG8; -.
DR SMR; Q9UPG8; -.
DR BioGRID; 111342; 55.
DR IntAct; Q9UPG8; 47.
DR STRING; 9606.ENSP00000246229; -.
DR iPTMnet; Q9UPG8; -.
DR PhosphoSitePlus; Q9UPG8; -.
DR BioMuta; PLAGL2; -.
DR DMDM; 14548188; -.
DR EPD; Q9UPG8; -.
DR jPOST; Q9UPG8; -.
DR MassIVE; Q9UPG8; -.
DR MaxQB; Q9UPG8; -.
DR PaxDb; Q9UPG8; -.
DR PeptideAtlas; Q9UPG8; -.
DR PRIDE; Q9UPG8; -.
DR ProteomicsDB; 85371; -.
DR Antibodypedia; 1784; 104 antibodies from 25 providers.
DR DNASU; 5326; -.
DR Ensembl; ENST00000246229.5; ENSP00000246229.4; ENSG00000126003.7.
DR GeneID; 5326; -.
DR KEGG; hsa:5326; -.
DR MANE-Select; ENST00000246229.5; ENSP00000246229.4; NM_002657.3; NP_002648.1.
DR UCSC; uc002wxn.3; human.
DR CTD; 5326; -.
DR DisGeNET; 5326; -.
DR GeneCards; PLAGL2; -.
DR HGNC; HGNC:9047; PLAGL2.
DR HPA; ENSG00000126003; Tissue enhanced (bone).
DR MIM; 604866; gene.
DR neXtProt; NX_Q9UPG8; -.
DR OpenTargets; ENSG00000126003; -.
DR PharmGKB; PA33380; -.
DR VEuPathDB; HostDB:ENSG00000126003; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160566; -.
DR HOGENOM; CLU_002678_66_1_1; -.
DR InParanoid; Q9UPG8; -.
DR OMA; CQCEISE; -.
DR OrthoDB; 615178at2759; -.
DR PhylomeDB; Q9UPG8; -.
DR TreeFam; TF332024; -.
DR PathwayCommons; Q9UPG8; -.
DR SignaLink; Q9UPG8; -.
DR SIGNOR; Q9UPG8; -.
DR BioGRID-ORCS; 5326; 44 hits in 1108 CRISPR screens.
DR ChiTaRS; PLAGL2; human.
DR GeneWiki; PLAGL2; -.
DR GenomeRNAi; 5326; -.
DR Pharos; Q9UPG8; Tbio.
DR PRO; PR:Q9UPG8; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9UPG8; protein.
DR Bgee; ENSG00000126003; Expressed in sperm and 136 other tissues.
DR Genevisible; Q9UPG8; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:ProtInc.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0034378; P:chylomicron assembly; IEA:Ensembl.
DR GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR027765; PLAG1/PLAGL2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24408:SF20; PTHR24408:SF20; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..496
FT /note="Zinc finger protein PLAGL2"
FT /id="PRO_0000047223"
FT ZN_FING 68..92
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 98..120
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 127..149
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 156..178
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 191..213
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 219..242
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 496 AA; 54584 MW; 20F5E7A28EF60603 CRC64;
MTTFFTSVPP WIQDAKQEEE VGWKLVPRPR GREAESQVKC QCEISGTPFS NGEKLRPHSL
PQPEQRPYSC PQLHCGKAFA SKYKLYRHMA THSAQKPHQC MYCDKMFHRK DHLRNHLQTH
DPNKEALHCS ECGKNYNTKL GYRRHLAMHA ASSGDLSCKV CLQTFESTQA LLEHLKAHSR
RVAGGAKEKK HPCDHCDRRF YTRKDVRRHL VVHTGRKDFL CQYCAQRFGR KDHLTRHVKK
SHSQELLKIK TEPVDMLGLL SCSSTVSVKE ELSPVLCMAS RDVMGTKAFP GMLPMGMYGA
HIPTMPSTGV PHSLVHNTLP MGMSYPLESS PISSPAQLPP KYQLGSTSYL PDKLPKVEVD
SFLAELPGSL SLSSAEPQPA SPQPAAAAAL LDEALLAKSP ANLSEALCAA NVDFSHLLGF
LPLNLPPCNP PGATGGLVMG YSQAEAQPLL TTLQAQPQDS PGAGGPLNFG PLHSLPPVFT
SGLSSTTLPR FHQAFQ
