PLAO1_PLAOI
ID PLAO1_PLAOI Reviewed; 170 AA.
AC A9YUH4;
DT 18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 25-MAY-2022, entry version 39.
DE RecName: Full=Putative invertase inhibitor {ECO:0000305};
DE AltName: Full=Pollen allergen Pla or 1 {ECO:0000303|PubMed:19173789, ECO:0000303|PubMed:19217563, ECO:0000303|PubMed:27255304, ECO:0000303|Ref.1};
DE AltName: Full=Pollen allergen Pla or 1.0101 {ECO:0000303|PubMed:19217563, ECO:0000303|Ref.1};
DE AltName: Allergen=Pla or 1.0101 {ECO:0000303|PubMed:19217563, ECO:0000303|Ref.1};
DE Flags: Precursor;
OS Platanus orientalis (Oriental plane-tree).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Proteales; Platanaceae; Platanus.
OX NCBI_TaxID=122832 {ECO:0000312|EMBL:ABY21305.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND ALLERGEN.
RC TISSUE=Pollen {ECO:0000303|Ref.1};
RX DOI=10.3923/rjbsci.2008.1419.1425;
RA Pazouki N., Sankian M., Nejadsattari T., Khavari-Nejad R.A., Varasteh A.R.;
RT "Complementary DNA Cloning and Immunologic Characterization of a New
RT Platanus orientalis Pollen Allergen, Pla or 1.0101.";
RL Res. J. Biol. Sci. 3:1419-1425(2008).
RN [2] {ECO:0000312|EMBL:ABY21305.1}
RP TISSUE SPECIFICITY, AND ALLERGEN.
RX PubMed=19173789; DOI=10.2500/aap.2008.29.3178;
RA Pazouki N., Sankian M., Nejadsattari T., Khavari-Nejad R.A., Varasteh A.R.;
RT "Oriental plane pollen allergy: identification of allergens and cross-
RT reactivity between relevant species.";
RL Allergy Asthma Proc. 29:622-628(2008).
RN [3] {ECO:0000312|EMBL:ABY21305.1}
RP ALLERGEN.
RX PubMed=19217563; DOI=10.1016/j.jbiosc.2008.10.016;
RA Pazouki N., Sankian M., Leung P.T., Nejadsattari T., Khavari-Nejad R.A.,
RA Varasteh A.R.;
RT "Identification of cyclophilin as a novel allergen from Platanus orientalis
RT pollens by mass spectrometry.";
RL J. Biosci. Bioeng. 107:215-217(2009).
RN [4]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=27255304; DOI=10.1007/s00484-016-1186-z;
RA Sedghy F., Sankian M., Moghadam M., Ghasemi Z., Mahmoudi M., Varasteh A.R.;
RT "Impact of traffic-related air pollution on the expression of Platanus
RT orientalis pollen allergens.";
RL Int. J. Biometeorol. 61:1-9(2017).
CC -!- TISSUE SPECIFICITY: Expressed in pollen (at protein level)
CC (PubMed:19173789, PubMed:27255304). Expressed in pollen (Ref.1,
CC PubMed:27255304). {ECO:0000269|PubMed:19173789,
CC ECO:0000269|PubMed:27255304, ECO:0000269|Ref.1}.
CC -!- INDUCTION: Expression of mRNA is induced by ground vehicle traffic-
CC related air pollution. No significant difference in the level of
CC protein expression between pollen samples collected from urban polluted
CC versus unpolluted areas. {ECO:0000269|PubMed:27255304}.
CC -!- ALLERGEN: Causes an allergic reaction in human (Ref.1, PubMed:19173789,
CC PubMed:19217563). Binds to IgE in 57% of the 7 patients tested allergic
CC to oriental plane-tree pollen (Ref.1, PubMed:19217563). Binds to IgE in
CC 21% of the 19 patients tested allergic to oriental plane-tree pollen
CC (PubMed:19173789). {ECO:0000269|PubMed:19173789,
CC ECO:0000269|PubMed:19217563, ECO:0000269|Ref.1}.
CC -!- SIMILARITY: Belongs to the PMEI family. {ECO:0000305}.
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DR EMBL; EU296476; ABY21305.1; -; mRNA.
DR AlphaFoldDB; A9YUH4; -.
DR SMR; A9YUH4; -.
DR Allergome; 2772; Pla or 1.
DR Allergome; 5770; Pla or 1.0101.
DR GO; GO:0004857; F:enzyme inhibitor activity; IEA:InterPro.
DR CDD; cd15795; PMEI-Pla_a_1_like; 1.
DR Gene3D; 1.20.140.40; -; 1.
DR InterPro; IPR035513; Invertase/methylesterase_inhib.
DR InterPro; IPR006501; Pectinesterase_inhib_dom.
DR InterPro; IPR034088; Pla_a_1-like.
DR Pfam; PF04043; PMEI; 1.
DR SMART; SM00856; PMEI; 1.
DR SUPFAM; SSF101148; SSF101148; 1.
DR TIGRFAMs; TIGR01614; PME_inhib; 1.
PE 1: Evidence at protein level;
KW Allergen; Disulfide bond; Signal.
FT SIGNAL 1..14
FT /evidence="ECO:0000250|UniProtKB:Q8GT41"
FT CHAIN 15..170
FT /note="Putative invertase inhibitor"
FT /evidence="ECO:0000250|UniProtKB:Q8GT41"
FT /id="PRO_5002745678"
FT DISULFID 22..37
FT /evidence="ECO:0000250|UniProtKB:Q9LNF2"
FT DISULFID 93..133
FT /evidence="ECO:0000250|UniProtKB:Q9LNF2"
SQ SEQUENCE 170 AA; 18219 MW; 265A1F03FB227FFE CRC64;
MKLSFSLCIF FLISADIVQG TCKKVAQRSP NVNYDFCVKS LGADPKSHSA DLQGLGVISA
NLAIQQGSKI QTFIGRILKS KVDPALKKYL NDCVGLYADA KSSVQEAIAD FKSKDYASAN
VKMSAALDDS VTCEDGFKEK KGIASPVTKE NKDYVQLTAI SLAITKLLGA
