ID   PLBL1_CAEEL             Reviewed;         571 AA.
AC   Q9XWV2;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Putative phospholipase B-like 1;
DE            EC=3.1.1.-;
DE   AltName: Full=LAMA-like protein 1;
DE   AltName: Full=Lamina ancestor homolog 1;
DE   Flags: Precursor;
GN   ORFNames=Y37D8A.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-62; ASN-442 AND ASN-473, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=Bristol N2;
RX   PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA   Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA   Taoka M., Takahashi N., Isobe T.;
RT   "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT   elegans and suggests an atypical translocation mechanism for integral
RT   membrane proteins.";
RL   Mol. Cell. Proteomics 6:2100-2109(2007).
CC   -!- FUNCTION: Putative phospholipase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the phospholipase B-like family. {ECO:0000305}.
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DR   EMBL; AL032626; CAA21539.1; -; Genomic_DNA.
DR   PIR; T26638; T26638.
DR   RefSeq; NP_499668.1; NM_067267.5.
DR   AlphaFoldDB; Q9XWV2; -.
DR   SMR; Q9XWV2; -.
DR   BioGRID; 41873; 6.
DR   STRING; 6239.Y37D8A.2; -.
DR   iPTMnet; Q9XWV2; -.
DR   EPD; Q9XWV2; -.
DR   PaxDb; Q9XWV2; -.
DR   PeptideAtlas; Q9XWV2; -.
DR   EnsemblMetazoa; Y37D8A.2.1; Y37D8A.2.1; WBGene00012544.
DR   GeneID; 176698; -.
DR   KEGG; cel:CELE_Y37D8A.2; -.
DR   UCSC; Y37D8A.2; c. elegans.
DR   CTD; 176698; -.
DR   WormBase; Y37D8A.2; CE20207; WBGene00012544; -.
DR   eggNOG; KOG3774; Eukaryota.
DR   GeneTree; ENSGT00530000063509; -.
DR   HOGENOM; CLU_027106_4_0_1; -.
DR   InParanoid; Q9XWV2; -.
DR   OMA; FQWSKSP; -.
DR   OrthoDB; 724258at2759; -.
DR   PhylomeDB; Q9XWV2; -.
DR   PRO; PR:Q9XWV2; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00012544; Expressed in larva and 4 other tissues.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0004620; F:phospholipase activity; IBA:GO_Central.
DR   GO; GO:0009395; P:phospholipid catabolic process; IBA:GO_Central.
DR   InterPro; IPR007000; PLipase_B-like.
DR   PANTHER; PTHR12370; PTHR12370; 1.
DR   Pfam; PF04916; Phospholip_B; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism; Lysosome;
KW   Reference proteome; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..571
FT                   /note="Putative phospholipase B-like 1"
FT                   /id="PRO_0000286113"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:17761667"
FT   CARBOHYD        149
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        442
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:17761667"
FT   CARBOHYD        473
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:17761667"
SQ   SEQUENCE   571 AA;  65439 MW;  7FAF9E951A8BF806 CRC64;
     MNWIFIFLAA AVAIGCEARQ ERTYTVCQKP EGDLHYFKEG RKTDEELCAK RLATAYFHDE
     VNQTGWAFLE VDVISPKIPH YLQGYAAGFA EGRATRHLID LHIINTVNGY CDGAKHFCDE
     LGEFMVDNLK WMEQEIRENP EDEYWQQVNL TVNQLFGLIH GYENQLGAEI DFKQIAVHPI
     FMIQIAGDLE DLAMKFKKPE NPKKVFSGPG HCSALVKLLP KNEDILFSHV TWSSYGTMLR
     INKKYSFKTG DPGQIYSFSS YPASITSTDD FVLTSAKLAI LETTIGNYNE KSLDLITPNT
     VLTWIRAEIA HRTASSGLQW AEAFGRHNSG TYNNEWVVVD YKQFHRGKEV QPETGIIHVV
     EQMPGHIVHS DKTAHLFRET YWPGYNQPYY KQIIRFSDTD KMVEKFGDWY SYDKTPRALI
     FKRDHNTVTD MSSMIALMRS NNYTKDPLSK CDCNPPYSAE NAIACRSDLN PLNGTYPFKS
     LGFRDHGAID VKVTNSKLIN SLQFTAVSGP PGGVTKDVPI FDWKTSPLRE KVPHFGQPDR
     WNFAPVTYKW RKDAHRHYHL YQKLHKELSS L