ID   PLBL2_BOVIN             Reviewed;         589 AA.
AC   Q2KIY5;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Putative phospholipase B-like 2;
DE            EC=3.1.1.-;
DE   AltName: Full=LAMA-like protein 2;
DE   AltName: Full=Lamina ancestor homolog 2;
DE   AltName: Full=Phospholipase B domain-containing protein 2;
DE   Flags: Precursor;
GN   Name=PLBD2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative phospholipase. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with IGF2R. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome lumen {ECO:0000250}.
CC   -!- PTM: Glycosylated; contains mannose 6-phosphate sugars. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the phospholipase B-like family. {ECO:0000305}.
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DR   EMBL; BC112461; AAI12462.1; -; mRNA.
DR   RefSeq; NP_001039635.1; NM_001046170.1.
DR   AlphaFoldDB; Q2KIY5; -.
DR   SMR; Q2KIY5; -.
DR   STRING; 9913.ENSBTAP00000025343; -.
DR   PaxDb; Q2KIY5; -.
DR   PRIDE; Q2KIY5; -.
DR   GeneID; 514347; -.
DR   KEGG; bta:514347; -.
DR   CTD; 196463; -.
DR   eggNOG; KOG3774; Eukaryota.
DR   InParanoid; Q2KIY5; -.
DR   OrthoDB; 724258at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0004620; F:phospholipase activity; IBA:GO_Central.
DR   GO; GO:0009395; P:phospholipid catabolic process; IBA:GO_Central.
DR   Gene3D; 1.10.439.20; -; 1.
DR   Gene3D; 2.10.70.60; -; 1.
DR   Gene3D; 3.60.60.20; -; 1.
DR   InterPro; IPR007000; PLipase_B-like.
DR   InterPro; IPR043040; PLipase_B-like_dom1.
DR   InterPro; IPR043041; PLipase_B-like_dom2.
DR   InterPro; IPR043042; PLipase_B-like_dom3.
DR   PANTHER; PTHR12370; PTHR12370; 1.
DR   Pfam; PF04916; Phospholip_B; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hydrolase; Lipid degradation;
KW   Lipid metabolism; Lysosome; Reference proteome; Signal.
FT   SIGNAL          1..41
FT                   /evidence="ECO:0000255"
FT   CHAIN           42..589
FT                   /note="Putative phospholipase B-like 2"
FT                   /id="PRO_0000286109"
FT   CARBOHYD        88
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        110
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        174
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        231
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        436
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        465
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        515
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        142..152
FT                   /evidence="ECO:0000250"
FT   DISULFID        492..495
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   589 AA;  65693 MW;  981183BB18CD327B CRC64;
     MVAPMYGSPG GRLARAVTRA LALALVLALL VGLFLSGLTG AIPTPRGQRG RGMPVPPASR
     CRSLLLDPET GQLRLVDGRH PDAVAWANLT NAIRETGWAF LELHTNGRFN DSLQAYAAGV
     VEAAVSEELI YMYWMNTVVN YCGPFEYEVG YCERLKNFLE ANLEWMQKEM ELNNGSAYWH
     QVRLTLLQLK GLEDSYEGSV AFPTGKFTVK PLGFLLLQIS GDLEDLEVAL NKTKTNHAMG
     SGSCSALIKL LPGQRDLLVA HNTWHSYQYM LRIMKKYWFQ FREGPQAEST RAPGNKVIFS
     SYPGTIFSCD DFYILGSGLV TLETTIGNKN PALWKYVQPT GCVLEWMRNV VANRLALDGD
     SWADIFKRFN SGTYNNQWMI VDYKAFVPGG PSPGRRVLTV LEQIPGMVVV ADRTSELYQK
     TYWASYNIPS FESVFNASGL PALVARYGPW FSYDGSPRAQ IFRRNHSLVH DLDSMMRLMR
     YNDFLHDPLS LCKACTPKPN GENAISARSD LNPANGSYPF QALHQRSHGG IDVKVTSTAL
     AKALRLLAVS GPTWDQLPPF QWSTSPFSGM LHMGQPDLRK FSPIEVSWD