ID   PLBLE_DICDI             Reviewed;         554 AA.
AC   Q54ZI6; Q8MN53;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Phospholipase B-like protein E;
DE            EC=3.1.1.-;
DE   Flags: Precursor;
GN   Name=plbE; ORFNames=DDB_G0277455;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable phospholipase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the phospholipase B-like family. {ECO:0000305}.
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DR   EMBL; AAFI02000020; EAL68690.1; -; Genomic_DNA.
DR   RefSeq; XP_642656.1; XM_637564.1.
DR   AlphaFoldDB; Q54ZI6; -.
DR   SMR; Q54ZI6; -.
DR   STRING; 44689.DDB0231380; -.
DR   PaxDb; Q54ZI6; -.
DR   EnsemblProtists; EAL68690; EAL68690; DDB_G0277455.
DR   GeneID; 8621072; -.
DR   KEGG; ddi:DDB_G0277455; -.
DR   dictyBase; DDB_G0277455; plbE.
DR   eggNOG; KOG3774; Eukaryota.
DR   HOGENOM; CLU_027106_4_0_1; -.
DR   InParanoid; Q54ZI6; -.
DR   OMA; MIRIYKR; -.
DR   PhylomeDB; Q54ZI6; -.
DR   PRO; PR:Q54ZI6; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0004620; F:phospholipase activity; ISS:dictyBase.
DR   GO; GO:0046338; P:phosphatidylethanolamine catabolic process; ISS:dictyBase.
DR   GO; GO:0031161; P:phosphatidylinositol catabolic process; ISS:dictyBase.
DR   GO; GO:0009395; P:phospholipid catabolic process; ISS:dictyBase.
DR   InterPro; IPR007000; PLipase_B-like.
DR   PANTHER; PTHR12370; PTHR12370; 1.
DR   Pfam; PF04916; Phospholip_B; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..554
FT                   /note="Phospholipase B-like protein E"
FT                   /id="PRO_0000286121"
FT   CARBOHYD        113
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        140
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        231
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        302
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        340
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        546
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   554 AA;  63730 MW;  A26388E39244A1B9 CRC64;
     MKLFILLIVI VFLISNSYSL SSSDSSSDSG SDVQYYSLTS QFQVVQGKQI PGSIAWGYFK
     DEMNKDGWGK LSIETVSTVS DNIAFKAAGY LEGYLTWEYI YKFSGNYFNS FFNTSNIKEI
     PTETLTFVSD NWEYMMERVN SSSTTDPYWI QIRNAMSQQI GLYEGYNAAA GEDYQKTFIE
     IYMINLYGDM GDIVTLTTTP NNEFIPMDRK EVEQLMATTG HCTSIIKLTN NCSDLMSAHT
     SWADFSVMIR IYKRINIPVA STPYGSETLF SSYPGLLVSI DDFYQIRPSK LHLTETLNTI
     LNQTLYQQIN AQSFMYWVRN LVANRLANNG FQWVSIFVEN NSGTNNIQFV VLDYKLFTPY
     STELQSDLLW IVEQYPGGYQ AADVTLTLWE QGYWPSYNRP YFEEVFDILG YPYYVEKFGD
     LFTYEYNPRA NIFRRDHSKL ETLQDMMNII DYNQYKTDPF SMGYPGNSIN ARFDIKGGSL
     PSGNPIYSWF YHGTHGGIDG KAINYDMVNS FTAVARNGPT VTSDCPPFNW NDWSLISHQY
     MPQIYNFTWI SINI