PLBL_DROME
ID PLBL_DROME Reviewed; 658 AA.
AC Q9VRK8; A4V1I2; Q8IH16; Q94898;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 3.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Putative phospholipase B-like lamina ancestor;
DE EC=3.1.1.-;
DE Flags: Precursor;
GN Name=lama; ORFNames=CG10645;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Embryo;
RX PubMed=8892229; DOI=10.1016/0925-4773(96)00556-4;
RA Perez S.E., Steller H.;
RT "Molecular and genetic analyses of lama, an evolutionarily conserved gene
RT expressed in the precursors of the Drosophila first optic ganglion.";
RL Mech. Dev. 59:11-27(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16077094; DOI=10.1242/dev.01927;
RA Klebes A., Sustar A., Kechris K., Li H., Schubiger G., Kornberg T.B.;
RT "Regulation of cellular plasticity in Drosophila imaginal disc cells by the
RT Polycomb group, trithorax group and lama genes.";
RL Development 132:3753-3765(2005).
RN [6]
RP ERRATUM OF PUBMED:16077094.
RA Klebes A., Sustar A., Kechris K., Li H., Schubiger G., Kornberg T.B.;
RL Development 132:4419-4419(2005).
CC -!- FUNCTION: Putative phospholipase (By similarity). Involved in the
CC regulation of cellular plasticity in imaginal disks. {ECO:0000250,
CC ECO:0000269|PubMed:16077094}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in neural and glial progenitors prior to,
CC but not after, differentiation. Not expressed in late third instar
CC disks, but is expressed uniformly by early third instar disks, in the
CC imaginal ring of the proventriculus and in the salivary gland.
CC {ECO:0000269|PubMed:16077094, ECO:0000269|PubMed:8892229}.
CC -!- SIMILARITY: Belongs to the phospholipase B-like family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB49926.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U57314; AAB49926.1; ALT_FRAME; mRNA.
DR EMBL; AE014296; AAF50787.3; -; Genomic_DNA.
DR EMBL; AE014296; AAG22333.2; -; Genomic_DNA.
DR EMBL; AE014296; AAN12118.2; -; Genomic_DNA.
DR EMBL; BT001475; AAN71230.1; -; mRNA.
DR RefSeq; NP_001261440.1; NM_001274511.1.
DR RefSeq; NP_523933.3; NM_079209.3.
DR RefSeq; NP_729059.2; NM_168115.2.
DR RefSeq; NP_729060.2; NM_168116.2.
DR AlphaFoldDB; Q9VRK8; -.
DR SMR; Q9VRK8; -.
DR BioGRID; 64076; 4.
DR IntAct; Q9VRK8; 2.
DR STRING; 7227.FBpp0076862; -.
DR GlyGen; Q9VRK8; 3 sites.
DR PaxDb; Q9VRK8; -.
DR PRIDE; Q9VRK8; -.
DR EnsemblMetazoa; FBtr0077159; FBpp0076862; FBgn0016031.
DR EnsemblMetazoa; FBtr0077160; FBpp0076863; FBgn0016031.
DR EnsemblMetazoa; FBtr0077161; FBpp0076864; FBgn0016031.
DR EnsemblMetazoa; FBtr0333595; FBpp0305772; FBgn0016031.
DR GeneID; 38610; -.
DR KEGG; dme:Dmel_CG10645; -.
DR CTD; 38610; -.
DR FlyBase; FBgn0016031; lama.
DR VEuPathDB; VectorBase:FBgn0016031; -.
DR eggNOG; KOG3774; Eukaryota.
DR GeneTree; ENSGT00530000063509; -.
DR HOGENOM; CLU_027106_2_0_1; -.
DR InParanoid; Q9VRK8; -.
DR OMA; NGWAQIE; -.
DR OrthoDB; 724258at2759; -.
DR PhylomeDB; Q9VRK8; -.
DR BioGRID-ORCS; 38610; 0 hits in 3 CRISPR screens.
DR ChiTaRS; LanA; fly.
DR GenomeRNAi; 38610; -.
DR PRO; PR:Q9VRK8; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0016031; Expressed in adult Malpighian tubule (Drosophila) and 36 other tissues.
DR ExpressionAtlas; Q9VRK8; baseline and differential.
DR Genevisible; Q9VRK8; DM.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0004620; F:phospholipase activity; ISS:FlyBase.
DR GO; GO:0046843; P:dorsal appendage formation; IMP:FlyBase.
DR GO; GO:0007444; P:imaginal disc development; IMP:UniProtKB.
DR GO; GO:0009395; P:phospholipid catabolic process; ISS:FlyBase.
DR InterPro; IPR007000; PLipase_B-like.
DR PANTHER; PTHR12370; PTHR12370; 1.
DR Pfam; PF04916; Phospholip_B; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..658
FT /note="Putative phospholipase B-like lamina ancestor"
FT /id="PRO_0000286116"
FT CARBOHYD 229
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 465
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 486
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 425
FT /note="K -> N (in Ref. 4; AAN71230)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 658 AA; 74874 MW; 48221A0CE76D7318 CRC64;
MLKVVGASWQ KTRIGTYILI GAGLLVIGAF FIGYMERPEY DGTYCATALW TKQVGFQIEN
WKQQNDLVNI PTGVGRICYK DSVYENGWAQ IEVETQRTYP DWVQAYAAGM LEGSLTWRNI
YNQWSNTISS SCERDESTQK FCGWLRDLLT TNYHRLKRQT EKAENDHYWH QLHLFITQLE
GLETGYKRGA SRARSDLEEE IPFSDFLLMN AAADIQDLKI YYENYELQNS TEHTEEPGTD
QPKNFFLPSA TMLTKIVQEE ESPQVLQLLF GHSTAGSYSS MLRIQKRYKF HYHFSSKLRS
NTVPGVDITF TGYPGILGST DDFYTIKGRH LHAIVGGVGI KNENLQLWKT VDPKKMVPLV
ARVMAANRIS QNRQTWASAM SRHPFTGAKQ WITVDLNKMK VQDNLYNVLE GDDKHDDAPV
VLNEKDRTAI QQRHDQLRDM VWIAEQLPGM MTKKDVTQGF LVPGNTSWLA NGVPYFKNVL
ELSGVNYSED QQLTVADEEE LTSLASVDKY LRTHGFRGDL LGSQESIAYG NIDLKLFSYN
ARLGISDFHA FAGPVFLRFQ HTQPRTLEDE GQDGGVPPAA SMGDERLSVS IEDADSLAEM
ELITERRSVR NDMRAIAMRK IGSGPFKWSE MSPVEEGGGH EGHPDEWNFD KVSPKWAW
