ID   A70A_DROSI              Reviewed;          55 AA.
AC   P67807; B4QJ08; O18666; Q6SE45;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Accessory gland-specific peptide 70A;
DE   AltName: Full=Paragonial peptide B;
DE   AltName: Full=Sex peptide;
DE            Short=SP;
DE   Flags: Precursor;
GN   Name=Acp70A; Synonyms=AcpA, PAPB; ORFNames=GD14439;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9286679; DOI=10.1093/genetics/147.1.189;
RA   Cirera S., Aguade M.N.;
RT   "Evolutionary history of the sex-peptide (Acp70A) gene region in Drosophila
RT   melanogaster.";
RL   Genetics 147:189-197(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26.
RX   PubMed=14762063; DOI=10.1101/gr.1329204;
RA   Halligan D.L., Eyre-Walker A., Andolfatto P., Keightley P.D.;
RT   "Patterns of evolutionary constraints in intronic and intergenic DNA of
RT   Drosophila.";
RL   Genome Res. 14:273-279(2004).
CC   -!- FUNCTION: Represses female sexual receptivity and stimulates
CC       oviposition.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Main cells of the accessory glands of males
CC       (paragonial gland).
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DR   EMBL; X99417; CAA67794.1; -; Genomic_DNA.
DR   EMBL; CM000363; EDX10339.1; -; Genomic_DNA.
DR   EMBL; AY459566; AAR23020.1; -; Genomic_DNA.
DR   RefSeq; XP_002084754.1; XM_002084718.2.
DR   AlphaFoldDB; P67807; -.
DR   SMR; P67807; -.
DR   EnsemblMetazoa; FBtr0214349; FBpp0212841; FBgn0021129.
DR   GeneID; 6737935; -.
DR   HOGENOM; CLU_3034552_0_0_1; -.
DR   OMA; PNPRDKW; -.
DR   PhylomeDB; P67807; -.
DR   Proteomes; UP000000304; Chromosome 3l.
DR   Bgee; FBgn0021129; Expressed in male reproductive system and 2 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0046008; P:regulation of female receptivity, post-mating; IEA:InterPro.
DR   InterPro; IPR012608; Sex_peptide.
DR   Pfam; PF08138; Sex_peptide; 1.
PE   2: Evidence at transcript level;
KW   Behavior; Disulfide bond; Hydroxylation; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..55
FT                   /note="Accessory gland-specific peptide 70A"
FT                   /id="PRO_0000020589"
FT   MOD_RES         28
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         32
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         34
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         38
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..55
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   55 AA;  6424 MW;  E87397C3F196123D CRC64;
     MKTLSLFLVL VCLLGLVQSW EWPWNRKPTK YPIPSPNPRD KWCRLNLGPA WGGRC