PLCR_PSEAE
ID PLCR_PSEAE Reviewed; 207 AA.
AC P40695;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Phospholipase C accessory protein PlcR;
DE Flags: Precursor;
GN Name=plcR; OrderedLocusNames=PA0843;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=3115961; DOI=10.1128/jb.169.10.4602-4607.1987;
RA Shen B.F., Tai P.C., Pritchard A.E., Vasil M.L.;
RT "Nucleotide sequences and expression in Escherichia coli of the in-phase
RT overlapping Pseudomonas aeruginosa plcR genes.";
RL J. Bacteriol. 169:4602-4607(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: May be involved in the regulation of synthesis of
CC phospholipase C.
CC -!- SUBCELLULAR LOCATION: [Isoform plcR1]: Periplasm.
CC -!- SUBCELLULAR LOCATION: [Isoform plcR2]: Cytoplasm.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=plcR1;
CC IsoId=P40695-1; Sequence=Displayed;
CC Name=plcR2;
CC IsoId=P40695-2; Sequence=VSP_018789;
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DR EMBL; M17745; AAA25970.1; -; Genomic_DNA.
DR EMBL; M17745; AAA25971.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG04232.1; -; Genomic_DNA.
DR PIR; A83540; A83540.
DR RefSeq; NP_249534.1; NC_002516.2. [P40695-1]
DR RefSeq; WP_003134321.1; NZ_QZGE01000007.1.
DR AlphaFoldDB; P40695; -.
DR SMR; P40695; -.
DR STRING; 287.DR97_1101; -.
DR PaxDb; P40695; -.
DR DNASU; 882099; -.
DR EnsemblBacteria; AAG04232; AAG04232; PA0843.
DR GeneID; 882099; -.
DR KEGG; pae:PA0843; -.
DR PATRIC; fig|208964.12.peg.875; -.
DR PseudoCAP; PA0843; -.
DR HOGENOM; CLU_116258_0_0_6; -.
DR OMA; FEIWMAL; -.
DR BioCyc; PAER208964:G1FZ6-858-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR InterPro; IPR017769; PLipase_C_acessory_PlcR.
DR TIGRFAMs; TIGR03398; plc_access_R; 1.
PE 3: Inferred from homology;
KW Alternative initiation; Cytoplasm; Periplasm; Reference proteome; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..207
FT /note="Phospholipase C accessory protein PlcR"
FT /id="PRO_0000022063"
FT REGION 37..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..56
FT /note="Missing (in isoform plcR2)"
FT /evidence="ECO:0000305"
FT /id="VSP_018789"
SQ SEQUENCE 207 AA; 23029 MW; A758A65ACCDD6CEF CRC64;
MRPTLTWTLL ALLLCGTAIG AVLLFYPSEP APVAPFASPP QATPAAKPSI PSRAPEMNTA
TAPDNLEQQL GEFGRNAGQM SEIERKQAAE GLIEQLKREV AVGADPRQTF EEIQRLTPYV
EADARRREAL DFEIWMALKD NASVQQQAPT PGEEEQLREY AQESDKVIAE VLASVDDEEQ
RHAAIDERLK ALRKQIFGEE NPRLLQR
