PLCX1_MOUSE
ID PLCX1_MOUSE Reviewed; 345 AA.
AC Q8CHS4; Q8BYI5;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=PI-PLC X domain-containing protein 1;
GN Name=Plcxd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 46-345.
RC STRAIN=C57BL/6J; TISSUE=Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=22732399; DOI=10.1016/j.bbrc.2012.06.079;
RA Gellatly S.A., Kalujnaia S., Cramb G.;
RT "Cloning, tissue distribution and sub-cellular localisation of
RT phospholipase C X-domain containing protein (PLCXD) isoforms.";
RL Biochem. Biophys. Res. Commun. 424:651-656(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NUJ7}.
CC -!- TISSUE SPECIFICITY: Expressed at highest levels in brain and kidney.
CC Also detected in stomach, thymus and skeletal muscle.
CC {ECO:0000269|PubMed:22732399}.
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DR EMBL; AK039459; BAC30356.1; -; mRNA.
DR EMBL; BC039627; AAH39627.1; -; mRNA.
DR AlphaFoldDB; Q8CHS4; -.
DR SMR; Q8CHS4; -.
DR STRING; 10090.ENSMUSP00000083892; -.
DR PhosphoSitePlus; Q8CHS4; -.
DR PaxDb; Q8CHS4; -.
DR PRIDE; Q8CHS4; -.
DR UCSC; uc012eax.1; mouse.
DR MGI; MGI:2685422; Plcxd1.
DR eggNOG; KOG4306; Eukaryota.
DR InParanoid; Q8CHS4; -.
DR PhylomeDB; Q8CHS4; -.
DR ChiTaRS; Plcxd1; mouse.
DR PRO; PR:Q8CHS4; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8CHS4; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IBA:GO_Central.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd08616; PI-PLCXD1c; 1.
DR Gene3D; 3.20.20.190; -; 1.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR042158; PLCXD1/2/3.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR SMART; SM00148; PLCXc; 1.
DR SUPFAM; SSF51695; SSF51695; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..345
FT /note="PI-PLC X domain-containing protein 1"
FT /id="PRO_0000304805"
FT DOMAIN 52..228
FT /note="PI-PLC X-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
FT CONFLICT 339
FT /note="N -> S (in Ref. 2; BAC30356)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 345 AA; 38718 MW; 7D83AD5926C40A56 CRC64;
MQGLEPSRVG RVGEVCRSVH KNVLTVPEHT VGTEAAAPMG DQADWMSQLC PQLWDVPLHH
LSIPGSHDTM TYCLNRKSRI SRASSWLLHL LGRVVPFITG PVVMKWSVTQ TLDVTQQLDA
GVRYLDLRIA HAPEGSTRNL CFVHMMYTKA LVEDTLTEIA EWLQSHPREV VILACRNFEG
MTCELHDYLA GCIVNIFGDM LCPSGEVPTL RQLWAREQQV IVSYEDEATV SRYDQLWPAI
PYWWGNAVKT DVLLRFLETM KGQGRPDGLF VAGINITENL CYILLHPVDS LEEMTRRSLP
LMTEWVCAQQ PGQSPQCTNI IAGDFVDADG FVSKVISLNC KLLSP
