PLCX2_HUMAN
ID PLCX2_HUMAN Reviewed; 305 AA.
AC Q0VAA5; Q96N12;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=PI-PLC X domain-containing protein 2;
GN Name=PLCXD2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=22732399; DOI=10.1016/j.bbrc.2012.06.079;
RA Gellatly S.A., Kalujnaia S., Cramb G.;
RT "Cloning, tissue distribution and sub-cellular localisation of
RT phospholipase C X-domain containing protein (PLCXD) isoforms.";
RL Biochem. Biophys. Res. Commun. 424:651-656(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22732399}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q0VAA5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0VAA5-2; Sequence=VSP_028349;
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:22732399}.
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DR EMBL; AK056141; BAB71103.1; -; mRNA.
DR EMBL; BC121155; AAI21156.1; -; mRNA.
DR EMBL; BC121156; AAI21157.1; -; mRNA.
DR CCDS; CCDS2961.1; -. [Q0VAA5-2]
DR CCDS; CCDS54619.1; -. [Q0VAA5-1]
DR RefSeq; NP_001172035.1; NM_001185106.1. [Q0VAA5-1]
DR RefSeq; NP_695000.1; NM_153268.3. [Q0VAA5-2]
DR AlphaFoldDB; Q0VAA5; -.
DR BioGRID; 129195; 5.
DR IntAct; Q0VAA5; 1.
DR STRING; 9606.ENSP00000420686; -.
DR iPTMnet; Q0VAA5; -.
DR PhosphoSitePlus; Q0VAA5; -.
DR BioMuta; PLCXD2; -.
DR DMDM; 121948095; -.
DR MassIVE; Q0VAA5; -.
DR PaxDb; Q0VAA5; -.
DR PeptideAtlas; Q0VAA5; -.
DR PRIDE; Q0VAA5; -.
DR ProteomicsDB; 58789; -. [Q0VAA5-1]
DR ProteomicsDB; 58790; -. [Q0VAA5-2]
DR Antibodypedia; 64569; 91 antibodies from 18 providers.
DR DNASU; 257068; -.
DR Ensembl; ENST00000393934.7; ENSP00000377511.3; ENSG00000240891.8. [Q0VAA5-2]
DR Ensembl; ENST00000477665.2; ENSP00000420686.1; ENSG00000240891.8. [Q0VAA5-1]
DR GeneID; 257068; -.
DR KEGG; hsa:257068; -.
DR MANE-Select; ENST00000477665.2; ENSP00000420686.1; NM_001185106.1; NP_001172035.1.
DR UCSC; uc003dxz.3; human. [Q0VAA5-1]
DR CTD; 257068; -.
DR DisGeNET; 257068; -.
DR GeneCards; PLCXD2; -.
DR HGNC; HGNC:26462; PLCXD2.
DR HPA; ENSG00000240891; Tissue enhanced (brain, retina).
DR MIM; 617015; gene.
DR neXtProt; NX_Q0VAA5; -.
DR OpenTargets; ENSG00000240891; -.
DR PharmGKB; PA134928848; -.
DR VEuPathDB; HostDB:ENSG00000240891; -.
DR eggNOG; KOG4306; Eukaryota.
DR GeneTree; ENSGT00940000162182; -.
DR HOGENOM; CLU_051926_0_0_1; -.
DR InParanoid; Q0VAA5; -.
DR OrthoDB; 477702at2759; -.
DR PhylomeDB; Q0VAA5; -.
DR TreeFam; TF314457; -.
DR PathwayCommons; Q0VAA5; -.
DR SignaLink; Q0VAA5; -.
DR BioGRID-ORCS; 257068; 7 hits in 1069 CRISPR screens.
DR ChiTaRS; PLCXD2; human.
DR GenomeRNAi; 257068; -.
DR Pharos; Q0VAA5; Tdark.
DR PRO; PR:Q0VAA5; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q0VAA5; protein.
DR Bgee; ENSG00000240891; Expressed in right lobe of liver and 135 other tissues.
DR ExpressionAtlas; Q0VAA5; baseline and differential.
DR Genevisible; Q0VAA5; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IBA:GO_Central.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR CDD; cd08616; PI-PLCXD1c; 1.
DR Gene3D; 3.20.20.190; -; 1.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR042158; PLCXD1/2/3.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR SMART; SM00148; PLCXc; 1.
DR SUPFAM; SSF51695; SSF51695; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Hydrolase; Lipid degradation; Lipid metabolism;
KW Nucleus; Reference proteome; Transducer.
FT CHAIN 1..305
FT /note="PI-PLC X domain-containing protein 2"
FT /id="PRO_0000305691"
FT DOMAIN 42..215
FT /note="PI-PLC X-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
FT ACT_SITE 57
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
FT ACT_SITE 132
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
FT VAR_SEQ 289..303
FT /note="SNRWNSHGPSLLSQE -> RLALIPVYPLRFSR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028349"
SQ SEQUENCE 305 AA; 34777 MW; 0684E6CFA9129D99 CRC64;
MLAVRKARRK LRMGTICSPN PSGTKTSSEV CNADWMASLP PHLHNLPLSN LAIPGSHDSF
SYWVDEKSPV GPDQTQAIKR LARISLVKKL MKKWSVTQNL TFREQLEAGI RYFDLRVSSK
PGDADQEIYF IHGLFGIKVW DGLMEIDSFL TQHPQEIIFL DFNHFYAMDE THHKCLVLRI
QEAFGNKLCP ACSVESLTLR TLWEKNCQVL IFYHCPFYKQ YPFLWPGKKI PAPWANTTSV
RKLILFLETT LSERASRGSF HVSQAILTPR VKTIARGLVG GLKNTLVHSN RWNSHGPSLL
SQERS
