ID   PLCX2_MOUSE             Reviewed;         340 AA.
AC   B2RXA1;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=PI-PLC X domain-containing protein 2;
GN   Name=Plcxd2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=22732399; DOI=10.1016/j.bbrc.2012.06.079;
RA   Gellatly S.A., Kalujnaia S., Cramb G.;
RT   "Cloning, tissue distribution and sub-cellular localisation of
RT   phospholipase C X-domain containing protein (PLCXD) isoforms.";
RL   Biochem. Biophys. Res. Commun. 424:651-656(2012).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q0VAA5}.
CC   -!- TISSUE SPECIFICITY: Expressed at highest levels in brain, followed by
CC       stomach and small intestine. Detected at low levels in kidney, ey,
CC       thymus and slkeletal muscle. {ECO:0000269|PubMed:22732399}.
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DR   EMBL; AC154773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC164979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC151059; AAI51060.1; -; mRNA.
DR   EMBL; BC151063; AAI51064.1; -; mRNA.
DR   CCDS; CCDS49863.1; -.
DR   RefSeq; NP_001127952.1; NM_001134480.1.
DR   AlphaFoldDB; B2RXA1; -.
DR   SMR; B2RXA1; -.
DR   STRING; 10090.ENSMUSP00000114852; -.
DR   iPTMnet; B2RXA1; -.
DR   PhosphoSitePlus; B2RXA1; -.
DR   MaxQB; B2RXA1; -.
DR   PaxDb; B2RXA1; -.
DR   PRIDE; B2RXA1; -.
DR   ProteomicsDB; 289617; -.
DR   Antibodypedia; 64569; 91 antibodies from 18 providers.
DR   Ensembl; ENSMUST00000130481; ENSMUSP00000114852; ENSMUSG00000087141.
DR   GeneID; 433022; -.
DR   KEGG; mmu:433022; -.
DR   UCSC; uc007zje.2; mouse.
DR   CTD; 257068; -.
DR   MGI; MGI:3647874; Plcxd2.
DR   VEuPathDB; HostDB:ENSMUSG00000087141; -.
DR   eggNOG; KOG4306; Eukaryota.
DR   GeneTree; ENSGT00940000162182; -.
DR   HOGENOM; CLU_051926_0_0_1; -.
DR   InParanoid; B2RXA1; -.
DR   OMA; TDQEIYF; -.
DR   OrthoDB; 477702at2759; -.
DR   PhylomeDB; B2RXA1; -.
DR   TreeFam; TF314457; -.
DR   BioGRID-ORCS; 433022; 2 hits in 74 CRISPR screens.
DR   ChiTaRS; Plcxd2; mouse.
DR   PRO; PR:B2RXA1; -.
DR   Proteomes; UP000000589; Chromosome 16.
DR   RNAct; B2RXA1; protein.
DR   Bgee; ENSMUSG00000087141; Expressed in inferior colliculus and 227 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008081; F:phosphoric diester hydrolase activity; IBA:GO_Central.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd08616; PI-PLCXD1c; 1.
DR   Gene3D; 3.20.20.190; -; 1.
DR   InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR   InterPro; IPR042158; PLCXD1/2/3.
DR   InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR   SMART; SM00148; PLCXc; 1.
DR   SUPFAM; SSF51695; SSF51695; 1.
DR   PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Lipid degradation; Lipid metabolism; Nucleus;
KW   Reference proteome; Transducer.
FT   CHAIN           1..340
FT                   /note="PI-PLC X domain-containing protein 2"
FT                   /id="PRO_0000437755"
FT   DOMAIN          42..215
FT                   /note="PI-PLC X-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
FT   ACT_SITE        57
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
FT   ACT_SITE        132
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
SQ   SEQUENCE   340 AA;  38618 MW;  5FD11EAE52EF15BA CRC64;
     MLAFRKARRK LRMGTICSPN PSGTKTASEV CNADWMASLP AHLHNVPLSN LAIPGSHDSF
     SYWVDEKSPV GPDQTQAVIR LARISLVKKL MKKWSVTQNL TFREQLEAGI RYFDLRVSSK
     PGDTDQEIYF IHGLFGIKVW DGLMEIDAFL TQHPQEIIFL DFNHFYAMDE SHHKCLVLRI
     QEAFGNKLCP ACSVESMTLR SLWEKKYQVL IFYHCPFYKQ YPFLWPGKKI PAPWANTTSV
     QKLILFLETT LSERAPRGAF HVSQAILTPR VKTIARGLVG GLKNTLVHRN LPAILDWVKT
     QKPGAMGVNI ITSDFVDLID FATTVIELND LLEDRALTKC