ID   PLCX3_DANRE             Reviewed;         322 AA.
AC   Q58EK3;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=PI-PLC X domain-containing protein 3;
GN   Name=plcxd3; ORFNames=zgc:110845;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BC091866; AAH91866.1; -; mRNA.
DR   RefSeq; NP_001014322.1; NM_001014300.1.
DR   AlphaFoldDB; Q58EK3; -.
DR   SMR; Q58EK3; -.
DR   STRING; 7955.ENSDARP00000071521; -.
DR   PaxDb; Q58EK3; -.
DR   Ensembl; ENSDART00000077053; ENSDARP00000071521; ENSDARG00000054794.
DR   GeneID; 541487; -.
DR   KEGG; dre:541487; -.
DR   CTD; 345557; -.
DR   ZFIN; ZDB-GENE-050327-10; plcxd3.
DR   eggNOG; KOG4306; Eukaryota.
DR   GeneTree; ENSGT00940000158747; -.
DR   HOGENOM; CLU_051926_0_0_1; -.
DR   InParanoid; Q58EK3; -.
DR   OMA; RIAQKDD; -.
DR   OrthoDB; 477702at2759; -.
DR   PhylomeDB; Q58EK3; -.
DR   TreeFam; TF314457; -.
DR   PRO; PR:Q58EK3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 8.
DR   Bgee; ENSDARG00000054794; Expressed in brain and 19 other tissues.
DR   ExpressionAtlas; Q58EK3; baseline.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0008081; F:phosphoric diester hydrolase activity; IBA:GO_Central.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd08616; PI-PLCXD1c; 1.
DR   Gene3D; 3.20.20.190; -; 1.
DR   InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR   InterPro; IPR042158; PLCXD1/2/3.
DR   InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR   SMART; SM00148; PLCXc; 1.
DR   SUPFAM; SSF51695; SSF51695; 1.
DR   PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Lipid degradation; Lipid metabolism; Reference proteome;
KW   Transducer.
FT   CHAIN           1..322
FT                   /note="PI-PLC X domain-containing protein 3"
FT                   /id="PRO_0000305695"
FT   DOMAIN          22..197
FT                   /note="PI-PLC X-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
FT   ACT_SITE        37
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
FT   ACT_SITE        114
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
SQ   SEQUENCE   322 AA;  36603 MW;  1C9B309F9FE9B2B4 CRC64;
     MASSQGKSEL RYADWMSSLP DTLHGIPLTN LAIPGSHDSF SFYIDEASPV GPEQPETVQN
     FVSVFGTVAK KLMRKWLATQ TMNFTSQLEA GIRFFDLRIS TKPRDPDNEL YFAHGLFSAT
     VREGLEQIST FLASHAREVV FLDFNHFYGV QNLHHEKLVQ MLRTVFGDRL CPVVFAQEVS
     LKYLWEKEYQ VLVFYHNPMA LEVPFLWPGQ MMPAPWANTT DPEKLILFLQ ASVKDRRRKG
     TFFVSQVVLT PKASTVMKGV TSGLRETITE RALPSMMQWI RSQRPGESGV NIITADFVEL
     GEFISAVITL NYYLDDEEEN AT