PLCX3_HUMAN
ID PLCX3_HUMAN Reviewed; 321 AA.
AC Q63HM9; A6NL04;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=PI-PLC X domain-containing protein 3;
GN Name=PLCXD3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterine endothelium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=22732399; DOI=10.1016/j.bbrc.2012.06.079;
RA Gellatly S.A., Kalujnaia S., Cramb G.;
RT "Cloning, tissue distribution and sub-cellular localisation of
RT phospholipase C X-domain containing protein (PLCXD) isoforms.";
RL Biochem. Biophys. Res. Commun. 424:651-656(2012).
CC -!- INTERACTION:
CC Q63HM9; P43364: MAGEA11; NbExp=3; IntAct=EBI-12105500, EBI-739552;
CC Q63HM9; P07237: P4HB; NbExp=3; IntAct=EBI-12105500, EBI-395883;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22732399}.
CC -!- TISSUE SPECIFICITY: Expressed at highest levels in heart. Also detected
CC in kidney, lung, small intestine and colon. Expressed at very low
CC levels, if any, in leukocytes, thymus and skeletal muscle.
CC {ECO:0000269|PubMed:22732399}.
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DR EMBL; BX648329; CAH56150.1; -; mRNA.
DR EMBL; AC008830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS34150.1; -.
DR RefSeq; NP_001005473.1; NM_001005473.2.
DR AlphaFoldDB; Q63HM9; -.
DR SMR; Q63HM9; -.
DR BioGRID; 131355; 3.
DR IntAct; Q63HM9; 2.
DR STRING; 9606.ENSP00000367032; -.
DR DrugBank; DB04339; Carbocisteine.
DR GlyConnect; 1606; 1 N-Linked glycan (1 site).
DR GlyGen; Q63HM9; 1 site, 1 N-linked glycan (1 site).
DR iPTMnet; Q63HM9; -.
DR PhosphoSitePlus; Q63HM9; -.
DR BioMuta; PLCXD3; -.
DR DMDM; 229462782; -.
DR MassIVE; Q63HM9; -.
DR MaxQB; Q63HM9; -.
DR PaxDb; Q63HM9; -.
DR PeptideAtlas; Q63HM9; -.
DR PRIDE; Q63HM9; -.
DR ProteomicsDB; 65882; -.
DR Antibodypedia; 23204; 27 antibodies from 11 providers.
DR DNASU; 345557; -.
DR Ensembl; ENST00000328457.5; ENSP00000333751.3; ENSG00000182836.10.
DR Ensembl; ENST00000377801.8; ENSP00000367032.3; ENSG00000182836.10.
DR GeneID; 345557; -.
DR KEGG; hsa:345557; -.
DR MANE-Select; ENST00000377801.8; ENSP00000367032.3; NM_001005473.3; NP_001005473.1.
DR UCSC; uc003jmm.2; human.
DR CTD; 345557; -.
DR DisGeNET; 345557; -.
DR GeneCards; PLCXD3; -.
DR HGNC; HGNC:31822; PLCXD3.
DR HPA; ENSG00000182836; Tissue enhanced (brain, heart muscle, ovary).
DR MIM; 617016; gene.
DR neXtProt; NX_Q63HM9; -.
DR OpenTargets; ENSG00000182836; -.
DR PharmGKB; PA134886053; -.
DR VEuPathDB; HostDB:ENSG00000182836; -.
DR eggNOG; KOG4306; Eukaryota.
DR GeneTree; ENSGT00940000158747; -.
DR HOGENOM; CLU_051926_0_0_1; -.
DR InParanoid; Q63HM9; -.
DR OMA; RIAQKDD; -.
DR OrthoDB; 477702at2759; -.
DR PhylomeDB; Q63HM9; -.
DR TreeFam; TF314457; -.
DR PathwayCommons; Q63HM9; -.
DR SignaLink; Q63HM9; -.
DR BioGRID-ORCS; 345557; 2 hits in 1064 CRISPR screens.
DR ChiTaRS; PLCXD3; human.
DR GenomeRNAi; 345557; -.
DR Pharos; Q63HM9; Tdark.
DR PRO; PR:Q63HM9; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q63HM9; protein.
DR Bgee; ENSG00000182836; Expressed in left ventricle myocardium and 139 other tissues.
DR Genevisible; Q63HM9; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IBA:GO_Central.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR CDD; cd08616; PI-PLCXD1c; 1.
DR Gene3D; 3.20.20.190; -; 1.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR042158; PLCXD1/2/3.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR SMART; SM00148; PLCXc; 1.
DR SUPFAM; SSF51695; SSF51695; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Hydrolase; Lipid degradation; Lipid metabolism;
KW Reference proteome; Transducer.
FT CHAIN 1..321
FT /note="PI-PLC X domain-containing protein 3"
FT /id="PRO_0000305693"
FT DOMAIN 22..197
FT /note="PI-PLC X-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
FT ACT_SITE 37
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
FT ACT_SITE 114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
FT CONFLICT 174
FT /note="I -> T (in Ref. 1; CAH56150)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 321 AA; 36313 MW; 8CAE049F287BD1B6 CRC64;
MASSQGKNEL KLADWMATLP ESMHSIPLTN LAIPGSHDSF SFYIDEASPV GPEQPETVQN
FVSVFGTVAK KLMRKWLATQ TMNFTGQLGA GIRYFDLRIS TKPRDPDNEL YFAHGLFSAK
VNEGLEEINA FLTDHHKEVV FLDFNHFYGM QKYHHEKLVQ MLKDIYGNKM CPAIFAQEVS
LKYLWEKDYQ VLVFYHSPVA LEVPFLWPGQ MMPAPWANTT DPEKLIQFLQ ASITERRKKG
SFFISQVVLT PKASTVVKGV ASGLRETITE RALPAMMQWV RTQKPGESGI NIVTADFVEL
GDFISTVIKL NYVFDEGEAN T
