PLCX3_MOUSE
ID PLCX3_MOUSE Reviewed; 321 AA.
AC Q8BLJ3; Q8BYR3;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=PI-PLC X domain-containing protein 3;
GN Name=Plcxd3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=22732399; DOI=10.1016/j.bbrc.2012.06.079;
RA Gellatly S.A., Kalujnaia S., Cramb G.;
RT "Cloning, tissue distribution and sub-cellular localisation of
RT phospholipase C X-domain containing protein (PLCXD) isoforms.";
RL Biochem. Biophys. Res. Commun. 424:651-656(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q63HM9}.
CC -!- TISSUE SPECIFICITY: Widely expressed, with highest levels in brain,
CC followed by heart atrium. Not detected in small intestine, nor stomach.
CC {ECO:0000269|PubMed:22732399}.
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DR EMBL; AK038575; BAC30052.1; -; mRNA.
DR EMBL; AK044972; BAC32164.1; -; mRNA.
DR CCDS; CCDS27362.2; -.
DR RefSeq; NP_796329.2; NM_177355.3.
DR AlphaFoldDB; Q8BLJ3; -.
DR SMR; Q8BLJ3; -.
DR STRING; 10090.ENSMUSP00000053553; -.
DR iPTMnet; Q8BLJ3; -.
DR PhosphoSitePlus; Q8BLJ3; -.
DR MaxQB; Q8BLJ3; -.
DR PaxDb; Q8BLJ3; -.
DR PRIDE; Q8BLJ3; -.
DR ProteomicsDB; 289541; -.
DR GeneID; 239318; -.
DR KEGG; mmu:239318; -.
DR CTD; 345557; -.
DR MGI; MGI:2442605; Plcxd3.
DR eggNOG; KOG4306; Eukaryota.
DR InParanoid; Q8BLJ3; -.
DR OrthoDB; 477702at2759; -.
DR PhylomeDB; Q8BLJ3; -.
DR BioGRID-ORCS; 239318; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Plcxd3; mouse.
DR PRO; PR:Q8BLJ3; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8BLJ3; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0045202; C:synapse; IDA:SynGO.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IBA:GO_Central.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR CDD; cd08616; PI-PLCXD1c; 1.
DR Gene3D; 3.20.20.190; -; 1.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR042158; PLCXD1/2/3.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR SMART; SM00148; PLCXc; 1.
DR SUPFAM; SSF51695; SSF51695; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Hydrolase; Lipid degradation; Lipid metabolism;
KW Reference proteome; Transducer.
FT CHAIN 1..321
FT /note="PI-PLC X domain-containing protein 3"
FT /id="PRO_0000305694"
FT DOMAIN 22..197
FT /note="PI-PLC X-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
FT ACT_SITE 37
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
FT ACT_SITE 114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
FT CONFLICT 164
FT /note="N -> D (in Ref. 1; BAC30052)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 321 AA; 36314 MW; 5662D449C89EFF39 CRC64;
MASSQGKNEL KFADWMATLP ESIHSIPLTN LAIPGSHDSF SFYIDEASPV GPEQPETVQN
FVSVFGTVAK KLMRKWLATQ TMSFTGQLGA GIRYFDLRIS TKPRDPDNEL YFAHGLFSAK
VNEGLEEINA FLTDHHKEVV FLDFNHFYGM QKYHHEKLVQ MLKNIYGNKM CPAIFAQEVS
LKYLWEKDYQ VLVFYHSPVA LEVPFLWPGQ MMPAPWANTT DPEKLIQFLQ ASITERRKKG
SFFISQVVLT PKASTVVKGV ASGLRETITE RALPAMMQWI RTQKPGESGI NIVTADFVEL
GDFISTVIKL NYVFNEGEAN T
