ID   PLC_HALLA               Reviewed;         155 AA.
AC   P82596; Q7M4F8;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   15-NOV-2002, sequence version 3.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Perlucin;
OS   Haliotis laevigata (Smooth Australian abalone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Vetigastropoda; Lepetellida; Haliotoidea; Haliotidae; Haliotis.
OX   NCBI_TaxID=36097;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Shell;
RX   PubMed=10931211; DOI=10.1046/j.1432-1327.2000.01602.x;
RA   Mann K., Weiss I.M., Andre S., Gabius H.-J., Fritz M.;
RT   "The amino-acid sequence of the abalone (Haliotis laevigata) nacre protein
RT   perlucin. Detection of a functional C-type lectin domain with
RT   galactose/mannose specificity.";
RL   Eur. J. Biochem. 267:5257-5264(2000).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 1-32.
RC   TISSUE=Shell;
RX   PubMed=10623567; DOI=10.1006/bbrc.1999.1907;
RA   Weiss I.M., Kaufmann S., Mann K., Fritz M.;
RT   "Purification and characterization of perlucin and perlustrin, two new
RT   proteins from the shell of the mollusc Haliotis laevigata.";
RL   Biochem. Biophys. Res. Commun. 267:17-21(2000).
CC   -!- FUNCTION: May promote nucleation and/or growth of calcium carbonate
CC       crystals. Binds to D-galactose and D-mannose/D-glucose.
CC       {ECO:0000269|PubMed:10931211}.
CC   -!- PTM: Glycosylated. {ECO:0000269|PubMed:10931211}.
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DR   PIR; S78774; S78774.
DR   AlphaFoldDB; P82596; -.
DR   SMR; P82596; -.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR018378; C-type_lectin_CS.
DR   InterPro; IPR016187; CTDL_fold.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Lectin; Repeat.
FT   CHAIN           1..155
FT                   /note="Perlucin"
FT                   /id="PRO_0000046722"
FT   DOMAIN          9..128
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   REPEAT          136..145
FT                   /note="1"
FT   REPEAT          146..155
FT                   /note="2"
FT   CARBOHYD        84
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   DISULFID        2..13
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        30..127
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        102..119
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   VARIANT         4
FT                   /note="L -> I"
FT                   /evidence="ECO:0000269|PubMed:10931211,
FT                   ECO:0000303|PubMed:10623567"
FT   VARIANT         4
FT                   /note="L -> P"
FT                   /evidence="ECO:0000269|PubMed:10931211,
FT                   ECO:0000303|PubMed:10623567"
FT   VARIANT         9
FT                   /note="N -> H"
FT                   /evidence="ECO:0000269|PubMed:10931211"
FT   VARIANT         11
FT                   /note="R -> G"
FT                   /evidence="ECO:0000269|PubMed:10931211,
FT                   ECO:0000303|PubMed:10623567"
FT   VARIANT         20
FT                   /note="K -> R"
FT                   /evidence="ECO:0000269|PubMed:10931211,
FT                   ECO:0000303|PubMed:10623567"
FT   VARIANT         45
FT                   /note="E -> D"
FT                   /evidence="ECO:0000269|PubMed:10931211"
FT   VARIANT         60
FT                   /note="F -> V"
FT                   /evidence="ECO:0000269|PubMed:10931211"
FT   VARIANT         61
FT                   /note="N -> K"
FT                   /evidence="ECO:0000269|PubMed:10931211"
FT   VARIANT         80
FT                   /note="Q -> E"
FT                   /evidence="ECO:0000269|PubMed:10931211"
FT   VARIANT         131
FT                   /note="R -> H"
FT                   /evidence="ECO:0000269|PubMed:10931211"
FT   VARIANT         133
FT                   /note="P -> S"
FT                   /evidence="ECO:0000269|PubMed:10931211"
FT   VARIANT         145
FT                   /note="R -> M"
FT                   /evidence="ECO:0000269|PubMed:10931211"
FT   VARIANT         155
FT                   /note="R -> K"
FT                   /evidence="ECO:0000269|PubMed:10931211"
FT   UNSURE          84
SQ   SEQUENCE   155 AA;  18155 MW;  CBB8AF788B878387 CRC64;
     GCPLGFHQNR RSCYWFSTIK SSFAEAAGYC RYLESHLAII SNKDEDSFIR GYATRLGEAF
     NYWLGASDLN IEGRWLWEGQ RRMNYTNWSP GQPDNAGGIE HCLELRRDLG NYLWNDYQCQ
     KPSHFICEKE RIPYTNSLHA NLQQRDSLHA NLQQR