PLD3A_MOUSE
ID PLD3A_MOUSE Reviewed; 172 AA.
AC Q8VE85;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=PRELI domain containing protein 3A;
DE AltName: Full=Protein slowmo homolog 1;
GN Name=Prelid3a; Synonyms=Slmo1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: In vitro, the TRIAP1:PRELID3A complex mediates the transfer
CC of phosphatidic acid (PA) between liposomes and probably functions as a
CC PA transporter across the mitochondrion intermembrane space.
CC Phosphatidic acid import is required for cardiolipin (CL) synthesis in
CC the mitochondrial inner membrane. {ECO:0000250|UniProtKB:Q96N28}.
CC -!- SUBUNIT: Interacts with TRIAP1. {ECO:0000250|UniProtKB:Q96N28}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q96N28}.
CC -!- SIMILARITY: Belongs to the slowmo family. {ECO:0000305}.
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DR EMBL; AK143220; BAE25314.1; -; mRNA.
DR EMBL; BC019561; AAH19561.1; -; mRNA.
DR CCDS; CCDS37848.1; -.
DR RefSeq; NP_659116.1; NM_144867.2.
DR RefSeq; XP_006525960.1; XM_006525897.3.
DR AlphaFoldDB; Q8VE85; -.
DR SMR; Q8VE85; -.
DR STRING; 10090.ENSMUSP00000025411; -.
DR MaxQB; Q8VE85; -.
DR PaxDb; Q8VE85; -.
DR PRIDE; Q8VE85; -.
DR ProteomicsDB; 289926; -.
DR Antibodypedia; 54064; 26 antibodies from 7 providers.
DR DNASU; 225655; -.
DR Ensembl; ENSMUST00000025411; ENSMUSP00000025411; ENSMUSG00000024530.
DR GeneID; 225655; -.
DR KEGG; mmu:225655; -.
DR UCSC; uc008fmi.1; mouse.
DR CTD; 10650; -.
DR MGI; MGI:2442865; Prelid3a.
DR VEuPathDB; HostDB:ENSMUSG00000024530; -.
DR eggNOG; KOG3336; Eukaryota.
DR GeneTree; ENSGT00950000182810; -.
DR HOGENOM; CLU_067902_7_0_1; -.
DR InParanoid; Q8VE85; -.
DR OMA; DPAEKKM; -.
DR OrthoDB; 1449441at2759; -.
DR PhylomeDB; Q8VE85; -.
DR TreeFam; TF312873; -.
DR Reactome; R-MMU-6803204; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.
DR BioGRID-ORCS; 225655; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Slmo1; mouse.
DR PRO; PR:Q8VE85; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8VE85; protein.
DR Bgee; ENSMUSG00000024530; Expressed in olfactory tubercle and 166 other tissues.
DR ExpressionAtlas; Q8VE85; baseline and differential.
DR Genevisible; Q8VE85; MM.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:1990050; F:phosphatidic acid transfer activity; ISO:MGI.
DR GO; GO:0015914; P:phospholipid transport; ISO:MGI.
DR InterPro; IPR006797; PRELI/MSF1_dom.
DR InterPro; IPR037365; Slowmo/Ups.
DR PANTHER; PTHR11158; PTHR11158; 1.
DR Pfam; PF04707; PRELI; 1.
DR PROSITE; PS50904; PRELI_MSF1; 1.
PE 1: Evidence at protein level;
KW Lipid transport; Mitochondrion; Reference proteome; Transport.
FT CHAIN 1..172
FT /note="PRELI domain containing protein 3A"
FT /id="PRO_0000295216"
FT DOMAIN 1..172
FT /note="PRELI/MSF1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00158"
FT SITE 36
FT /note="Important for interaction with TRIAP1"
FT /evidence="ECO:0000250|UniProtKB:Q96N28"
FT SITE 49
FT /note="Important for interaction with TRIAP1"
FT /evidence="ECO:0000250|UniProtKB:Q96N28"
SQ SEQUENCE 172 AA; 19026 MW; F022A0B2CECDAC66 CRC64;
MKIWSSEHVF GHPWDTVIKA AMRKYPNPMN PCVVGVDVLE RSVDGCGRLH SLRLLSTEWG
LPGLVRAILG ANRTLTYIKE RSVVDPAARK MELCSTNITL TNLVSVNERL VYTPHPENPE
KTVLTQEAII TVKGISLGSY LESLMATTIS SNAKKGWAAI EWIIEHSESA IS
