ID   PLD3A_XENLA             Reviewed;         172 AA.
AC   Q6GM21;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=PRELI domain containing protein 3A;
DE   AltName: Full=Protein slowmo homolog 1;
GN   Name=prelid3a; Synonyms=slmo1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In vitro, the triap1:prelid3a complex mediates the transfer
CC       of phosphatidic acid (PA) between liposomes and probably functions as a
CC       PA transporter across the mitochondrion intermembrane space.
CC       Phosphatidic acid import is required for cardiolipin (CL) synthesis in
CC       the mitochondrial inner membrane. {ECO:0000250|UniProtKB:Q96N28}.
CC   -!- SUBUNIT: Interacts with triap1. {ECO:0000250|UniProtKB:Q96N28}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q96N28}.
CC   -!- SIMILARITY: Belongs to the slowmo family. {ECO:0000305}.
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DR   EMBL; BC074268; AAH74268.1; -; mRNA.
DR   RefSeq; NP_001086156.1; NM_001092687.1.
DR   AlphaFoldDB; Q6GM21; -.
DR   SMR; Q6GM21; -.
DR   DNASU; 444585; -.
DR   GeneID; 444585; -.
DR   KEGG; xla:444585; -.
DR   CTD; 444585; -.
DR   Xenbase; XB-GENE-6254878; prelid3a.L.
DR   OMA; DPAEKKM; -.
DR   OrthoDB; 1449441at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 444585; Expressed in brain and 6 other tissues.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006797; PRELI/MSF1_dom.
DR   InterPro; IPR037365; Slowmo/Ups.
DR   PANTHER; PTHR11158; PTHR11158; 1.
DR   Pfam; PF04707; PRELI; 1.
DR   PROSITE; PS50904; PRELI_MSF1; 1.
PE   2: Evidence at transcript level;
KW   Lipid transport; Mitochondrion; Reference proteome; Transport.
FT   CHAIN           1..172
FT                   /note="PRELI domain containing protein 3A"
FT                   /id="PRO_0000295217"
FT   DOMAIN          1..172
FT                   /note="PRELI/MSF1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00158"
FT   SITE            36
FT                   /note="Important for interaction with triap1"
FT                   /evidence="ECO:0000250|UniProtKB:Q96N28"
FT   SITE            49
FT                   /note="Important for interaction with triap1"
FT                   /evidence="ECO:0000250|UniProtKB:Q96N28"
SQ   SEQUENCE   172 AA;  19248 MW;  17BB4346E19FDB68 CRC64;
     MRIWSSEHVF SHPWDTVIKA AMRKYPNPMN PCVVGVDVVD RNLDSQGRLH SQRLLCTEWG
     LPSLVRAILG TSRTLTYIKE HSVVDPVEKK MVLCSTNISL TNLVSVDERL VYTPHPENPE
     QTVLTQEAII TVKGVSLSSY LEGLMASTIS SNARKGWDAI EWIIQNSEST VS