PLD3B_HUMAN
ID PLD3B_HUMAN Reviewed; 194 AA.
AC Q9Y3B1; E1P5I8; Q5JX17; Q9NUL0;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2002, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=PRELI domain containing protein 3B;
DE AltName: Full=Protein slowmo homolog 2;
GN Name=PRELID3B; Synonyms=C20orf45, SLMO2; ORFNames=CGI-107;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y3B1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y3B1-2; Sequence=VSP_044840;
CC -!- SIMILARITY: Belongs to the slowmo family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD34102.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF151865; AAD34102.1; ALT_FRAME; mRNA.
DR EMBL; AK002157; BAA92114.1; -; mRNA.
DR EMBL; AK298135; BAG60414.1; -; mRNA.
DR EMBL; AL109840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW75442.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW75443.1; -; Genomic_DNA.
DR EMBL; BC010649; AAH10649.1; -; mRNA.
DR EMBL; BC013969; AAH13969.1; -; mRNA.
DR CCDS; CCDS42893.1; -. [Q9Y3B1-1]
DR CCDS; CCDS58783.1; -. [Q9Y3B1-2]
DR RefSeq; NP_001243332.1; NM_001256403.1. [Q9Y3B1-2]
DR RefSeq; NP_057129.2; NM_016045.2. [Q9Y3B1-1]
DR PDB; 6I4Y; X-ray; 2.91 A; B=1-194.
DR PDBsum; 6I4Y; -.
DR AlphaFoldDB; Q9Y3B1; -.
DR SMR; Q9Y3B1; -.
DR BioGRID; 119219; 7.
DR IntAct; Q9Y3B1; 22.
DR STRING; 9606.ENSP00000348206; -.
DR iPTMnet; Q9Y3B1; -.
DR PhosphoSitePlus; Q9Y3B1; -.
DR BioMuta; PRELID3B; -.
DR DMDM; 26392626; -.
DR EPD; Q9Y3B1; -.
DR jPOST; Q9Y3B1; -.
DR MassIVE; Q9Y3B1; -.
DR MaxQB; Q9Y3B1; -.
DR PaxDb; Q9Y3B1; -.
DR PeptideAtlas; Q9Y3B1; -.
DR PRIDE; Q9Y3B1; -.
DR ProteomicsDB; 63414; -.
DR ProteomicsDB; 85999; -. [Q9Y3B1-1]
DR Antibodypedia; 44276; 108 antibodies from 17 providers.
DR DNASU; 51012; -.
DR Ensembl; ENST00000355937.9; ENSP00000348206.4; ENSG00000101166.16. [Q9Y3B1-1]
DR Ensembl; ENST00000371033.9; ENSP00000360072.5; ENSG00000101166.16. [Q9Y3B1-2]
DR GeneID; 51012; -.
DR KEGG; hsa:51012; -.
DR MANE-Select; ENST00000355937.9; ENSP00000348206.4; NM_016045.3; NP_057129.2.
DR UCSC; uc002yam.4; human. [Q9Y3B1-1]
DR CTD; 51012; -.
DR DisGeNET; 51012; -.
DR GeneCards; PRELID3B; -.
DR HGNC; HGNC:15892; PRELID3B.
DR HPA; ENSG00000101166; Low tissue specificity.
DR neXtProt; NX_Q9Y3B1; -.
DR OpenTargets; ENSG00000101166; -.
DR PharmGKB; PA162403922; -.
DR VEuPathDB; HostDB:ENSG00000101166; -.
DR eggNOG; KOG3336; Eukaryota.
DR GeneTree; ENSGT00950000182810; -.
DR HOGENOM; CLU_067902_7_0_1; -.
DR InParanoid; Q9Y3B1; -.
DR OMA; AMSRRVF; -.
DR OrthoDB; 1449441at2759; -.
DR PhylomeDB; Q9Y3B1; -.
DR TreeFam; TF312873; -.
DR PathwayCommons; Q9Y3B1; -.
DR SignaLink; Q9Y3B1; -.
DR BioGRID-ORCS; 51012; 788 hits in 1069 CRISPR screens.
DR GenomeRNAi; 51012; -.
DR Pharos; Q9Y3B1; Tdark.
DR PRO; PR:Q9Y3B1; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9Y3B1; protein.
DR Bgee; ENSG00000101166; Expressed in rectum and 194 other tissues.
DR ExpressionAtlas; Q9Y3B1; baseline and differential.
DR Genevisible; Q9Y3B1; HS.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR GO; GO:1990050; F:phosphatidic acid transfer activity; IBA:GO_Central.
DR GO; GO:0015914; P:phospholipid transport; IBA:GO_Central.
DR InterPro; IPR006797; PRELI/MSF1_dom.
DR InterPro; IPR037365; Slowmo/Ups.
DR PANTHER; PTHR11158; PTHR11158; 1.
DR Pfam; PF04707; PRELI; 1.
DR PROSITE; PS50904; PRELI_MSF1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..194
FT /note="PRELI domain containing protein 3B"
FT /id="PRO_0000079429"
FT DOMAIN 1..172
FT /note="PRELI/MSF1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00158"
FT MOD_RES 46
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P9U4"
FT MOD_RES 51
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P9U4"
FT VAR_SEQ 68..97
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044840"
FT STRAND 3..12
FT /evidence="ECO:0007829|PDB:6I4Y"
FT HELIX 14..22
FT /evidence="ECO:0007829|PDB:6I4Y"
FT STRAND 33..43
FT /evidence="ECO:0007829|PDB:6I4Y"
FT STRAND 49..58
FT /evidence="ECO:0007829|PDB:6I4Y"
FT HELIX 65..71
FT /evidence="ECO:0007829|PDB:6I4Y"
FT STRAND 75..85
FT /evidence="ECO:0007829|PDB:6I4Y"
FT TURN 86..89
FT /evidence="ECO:0007829|PDB:6I4Y"
FT STRAND 90..97
FT /evidence="ECO:0007829|PDB:6I4Y"
FT TURN 99..103
FT /evidence="ECO:0007829|PDB:6I4Y"
FT STRAND 107..115
FT /evidence="ECO:0007829|PDB:6I4Y"
FT STRAND 118..129
FT /evidence="ECO:0007829|PDB:6I4Y"
FT STRAND 132..135
FT /evidence="ECO:0007829|PDB:6I4Y"
FT HELIX 137..170
FT /evidence="ECO:0007829|PDB:6I4Y"
SQ SEQUENCE 194 AA; 21495 MW; DF32EA44992BFA94 CRC64;
MKIWTSEHVF DHPWETVTTA AMQKYPNPMN PSVVGVDVLD RHIDPSGKLH SHRLLSTEWG
LPSIVKSLIG AARTKTYVQE HSVVDPVEKT MELKSTNISF TNMVSVDERL IYKPHPQDPE
KTVLTQEAII TVKGVSLSSY LEGLMASTIS SNASKGREAM EWVIHKLNAE IEELTASARG
TIRTPMAAAA FAEK
