PLD3B_MOUSE
ID PLD3B_MOUSE Reviewed; 195 AA.
AC Q9CYY7; A2ADM7; Q3UC64; Q9CRD3;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2002, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=PRELI domain containing protein 3B;
DE AltName: Full=Protein slowmo homolog 2;
GN Name=Prelid3b; Synonyms=Slmo2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow macrophage, Brain, and Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the slowmo family. {ECO:0000305}.
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DR EMBL; AK003043; BAB22528.1; -; mRNA.
DR EMBL; AK008542; BAB25731.1; -; mRNA.
DR EMBL; AK150668; BAE29750.1; -; mRNA.
DR EMBL; AL670951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC026968; AAH26968.1; -; mRNA.
DR CCDS; CCDS17155.1; -.
DR RefSeq; NP_079807.1; NM_025531.2.
DR AlphaFoldDB; Q9CYY7; -.
DR SMR; Q9CYY7; -.
DR STRING; 10090.ENSMUSP00000016401; -.
DR PhosphoSitePlus; Q9CYY7; -.
DR EPD; Q9CYY7; -.
DR MaxQB; Q9CYY7; -.
DR PaxDb; Q9CYY7; -.
DR PeptideAtlas; Q9CYY7; -.
DR PRIDE; Q9CYY7; -.
DR ProteomicsDB; 289927; -.
DR Antibodypedia; 44276; 108 antibodies from 17 providers.
DR DNASU; 66390; -.
DR Ensembl; ENSMUST00000016401; ENSMUSP00000016401; ENSMUSG00000016257.
DR GeneID; 66390; -.
DR KEGG; mmu:66390; -.
DR UCSC; uc008ofg.1; mouse.
DR CTD; 51012; -.
DR MGI; MGI:1913640; Prelid3b.
DR VEuPathDB; HostDB:ENSMUSG00000016257; -.
DR eggNOG; KOG3336; Eukaryota.
DR GeneTree; ENSGT00950000182810; -.
DR HOGENOM; CLU_067902_7_0_1; -.
DR InParanoid; Q9CYY7; -.
DR OMA; AMSRRVF; -.
DR OrthoDB; 1449441at2759; -.
DR PhylomeDB; Q9CYY7; -.
DR TreeFam; TF312873; -.
DR BioGRID-ORCS; 66390; 25 hits in 72 CRISPR screens.
DR ChiTaRS; Prelid3b; mouse.
DR PRO; PR:Q9CYY7; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9CYY7; protein.
DR Bgee; ENSMUSG00000016257; Expressed in ear vesicle and 249 other tissues.
DR ExpressionAtlas; Q9CYY7; baseline and differential.
DR Genevisible; Q9CYY7; MM.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:1990050; F:phosphatidic acid transfer activity; IBA:GO_Central.
DR GO; GO:0015914; P:phospholipid transport; IBA:GO_Central.
DR InterPro; IPR006797; PRELI/MSF1_dom.
DR InterPro; IPR037365; Slowmo/Ups.
DR PANTHER; PTHR11158; PTHR11158; 1.
DR Pfam; PF04707; PRELI; 1.
DR PROSITE; PS50904; PRELI_MSF1; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..195
FT /note="PRELI domain containing protein 3B"
FT /id="PRO_0000079430"
FT DOMAIN 1..172
FT /note="PRELI/MSF1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00158"
FT MOD_RES 46
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P9U4"
FT MOD_RES 51
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P9U4"
FT CONFLICT 194
FT /note="D -> N (in Ref. 1; BAE29750)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 195 AA; 21492 MW; 003CDA86C29E6779 CRC64;
MKIWTSEHVF DHPWETVTTA AMQKYPNPMN PSVVGVDVLD RHVDPSGKLH SHRLLSTEWG
LPSIVKSLIG AARTKTYVQE HSVVDPVTRT MELKSTNISF TNMVSVDERL TYKPHLQDPE
KTVLTQEALI TVKGVSLSSY LEGLMASTIS SNASKGREAM EWVIHKLNAE IEELAASARG
SIRTPMAAAA ALVDK
