ID   ASTE1_DANRE             Reviewed;         692 AA.
AC   Q1LYL8; B3DJH6;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Protein asteroid homolog 1;
GN   Name=aste1; ORFNames=si:dkey-11p23.5;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in EGF receptor signaling. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the asteroid family. {ECO:0000305}.
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DR   EMBL; BX005012; CAK05130.1; -; Genomic_DNA.
DR   EMBL; BC163487; AAI63487.1; -; mRNA.
DR   EMBL; BC163493; AAI63493.1; -; mRNA.
DR   RefSeq; NP_001092900.1; NM_001099430.1.
DR   RefSeq; XP_005158251.1; XM_005158194.3.
DR   AlphaFoldDB; Q1LYL8; -.
DR   STRING; 7955.ENSDARP00000106061; -.
DR   PaxDb; Q1LYL8; -.
DR   Ensembl; ENSDART00000102665; ENSDARP00000093440; ENSDARG00000070132.
DR   GeneID; 100006826; -.
DR   KEGG; dre:100006826; -.
DR   CTD; 100006826; -.
DR   ZFIN; ZDB-GENE-060503-520; aste1a.
DR   eggNOG; ENOG502QQRA; Eukaryota.
DR   GeneTree; ENSGT00390000010145; -.
DR   HOGENOM; CLU_017330_1_0_1; -.
DR   InParanoid; Q1LYL8; -.
DR   OMA; PYETNDV; -.
DR   OrthoDB; 966573at2759; -.
DR   PhylomeDB; Q1LYL8; -.
DR   TreeFam; TF324582; -.
DR   PRO; PR:Q1LYL8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 16.
DR   Bgee; ENSDARG00000070132; Expressed in intestine and 14 other tissues.
DR   InterPro; IPR026832; Asteroid.
DR   InterPro; IPR039436; Asteroid_dom.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR15665; PTHR15665; 1.
DR   Pfam; PF12813; XPG_I_2; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..692
FT                   /note="Protein asteroid homolog 1"
FT                   /id="PRO_0000310461"
SQ   SEQUENCE   692 AA;  79228 MW;  F7BEDA8D08BF4C79 CRC64;
     MGVQGLKTYI ESSSRNDLKT WAFRDKQLII DGCNLFYSLC FDSNLDQIHG GDYDTFEKVV
     RQFFENLSAC DVHPYVVIDG GDDHTDKKWD TLLTRKQKKI KDAYDLSVGK RRQVLPLLTE
     KVFKQVLKKL KVPVVQTLEE ADWEIAALAE EWNCPVLSND SDFYIFNLRA GLLPITHFHW
     RKVRVNRKTN QKFILSKHFI ARKFCKSFKM NVSLLPVFAS ILGNDYVKLP NIKNRHWERY
     SNPGSENPQI EGLLNWLSQF SGPDEAISAL LRPTSNKTKA QEELSHGIQD YKLVPGSLAQ
     IFRSTKVPQK ISKGPLHVLP RWTLRPILDG KMSSYIINVL LHNRASLNAQ VEDFQLPSAN
     ETSLHIRQVF YGLLLLGEQQ TAGKRESVKG TTKRYVVEYS RQQIKRSSEN VEAIQTKAME
     GLRLETLYQE PHAVRLQVIL DTLGVSCEML KGTPDALQLQ MFVTRYWLVN AEPQPCRVHL
     WGLLLGMVYG KLSSSPNAQK DMLSRLRVKA SRKGGSVDID VAHAYSQWQS CLKYSLNLNY
     LLSFPLTEPD CASLYRGSLV HQAVGELRRG ISLEALLVKG SSAERIFKQL KDIIVSLMGD
     DFIKKMKSGL EHRDAGKTQR ASKGQKDELD IYFEQMMIES IDSEDEELLD VRKSKAKNHL
     MELPVCPIRA RHKAKARNAR HPCKKYERRC FE