PLD5_HUMAN
ID PLD5_HUMAN Reviewed; 536 AA.
AC Q8N7P1; A1KXV0; B7Z324; Q494U9; Q8NB22;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Inactive phospholipase D5;
DE Short=Inactive PLD 5;
DE AltName: Full=Inactive choline phosphatase 5;
DE AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5;
DE AltName: Full=PLDc;
GN Name=PLD5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
RA Li X., Xie Y., Mao Y.;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
RC TISSUE=Brain, Corpus callosum, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 46-536 (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8N7P1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N7P1-2; Sequence=VSP_025725;
CC Name=3;
CC IsoId=Q8N7P1-3; Sequence=VSP_025724;
CC Name=4;
CC IsoId=Q8N7P1-4; Sequence=VSP_025726, VSP_025727;
CC -!- SIMILARITY: Belongs to the phospholipase D family. {ECO:0000305}.
CC -!- CAUTION: In contrast to other members of the family, it lacks the
CC conserved active sites, suggesting that it has no phospholipase
CC activity. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI01374.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI01375.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI01376.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY461578; AAS91020.1; -; mRNA.
DR EMBL; AK091691; BAC03722.1; -; mRNA.
DR EMBL; AK098092; BAC05230.1; -; mRNA.
DR EMBL; AK295421; BAH12060.1; -; mRNA.
DR EMBL; AL360271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL583845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL591686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL445704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC101373; AAI01374.1; ALT_INIT; mRNA.
DR EMBL; BC101374; AAI01375.1; ALT_INIT; mRNA.
DR EMBL; BC101375; AAI01376.1; ALT_INIT; mRNA.
DR CCDS; CCDS1621.2; -. [Q8N7P1-1]
DR CCDS; CCDS55692.1; -. [Q8N7P1-4]
DR RefSeq; NP_001182740.1; NM_001195811.1. [Q8N7P1-4]
DR RefSeq; NP_001182741.1; NM_001195812.1. [Q8N7P1-3]
DR RefSeq; NP_001307201.1; NM_001320272.1. [Q8N7P1-2]
DR RefSeq; NP_689879.2; NM_152666.2.
DR RefSeq; XP_006711815.1; XM_006711752.2.
DR RefSeq; XP_011542417.1; XM_011544115.2.
DR RefSeq; XP_011542418.1; XM_011544116.2.
DR RefSeq; XP_011542422.1; XM_011544120.2. [Q8N7P1-3]
DR RefSeq; XP_011542423.1; XM_011544121.2. [Q8N7P1-3]
DR RefSeq; XP_011542424.1; XM_011544122.2. [Q8N7P1-3]
DR RefSeq; XP_016856056.1; XM_017000567.1. [Q8N7P1-2]
DR RefSeq; XP_016856057.1; XM_017000568.1. [Q8N7P1-2]
DR RefSeq; XP_016856058.1; XM_017000569.1. [Q8N7P1-3]
DR RefSeq; XP_016856059.1; XM_017000570.1. [Q8N7P1-3]
DR AlphaFoldDB; Q8N7P1; -.
DR SMR; Q8N7P1; -.
DR BioGRID; 128302; 41.
DR STRING; 9606.ENSP00000440896; -.
DR GlyGen; Q8N7P1; 2 sites.
DR iPTMnet; Q8N7P1; -.
DR PhosphoSitePlus; Q8N7P1; -.
DR BioMuta; PLD5; -.
DR DMDM; 152112223; -.
DR EPD; Q8N7P1; -.
DR jPOST; Q8N7P1; -.
DR MassIVE; Q8N7P1; -.
DR PaxDb; Q8N7P1; -.
DR PeptideAtlas; Q8N7P1; -.
DR PRIDE; Q8N7P1; -.
DR ProteomicsDB; 72311; -. [Q8N7P1-1]
DR ProteomicsDB; 72312; -. [Q8N7P1-2]
DR ProteomicsDB; 72313; -. [Q8N7P1-3]
DR ProteomicsDB; 72314; -. [Q8N7P1-4]
DR Antibodypedia; 34707; 126 antibodies from 20 providers.
DR DNASU; 200150; -.
DR Ensembl; ENST00000427495.5; ENSP00000401285.1; ENSG00000180287.17. [Q8N7P1-4]
DR Ensembl; ENST00000442594.6; ENSP00000414188.3; ENSG00000180287.17. [Q8N7P1-1]
DR Ensembl; ENST00000536534.7; ENSP00000440896.1; ENSG00000180287.17. [Q8N7P1-1]
DR GeneID; 200150; -.
DR KEGG; hsa:200150; -.
DR MANE-Select; ENST00000536534.7; ENSP00000440896.1; NM_001372062.1; NP_001358991.1.
DR UCSC; uc001hzl.4; human. [Q8N7P1-1]
DR CTD; 200150; -.
DR DisGeNET; 200150; -.
DR GeneCards; PLD5; -.
DR HGNC; HGNC:26879; PLD5.
DR HPA; ENSG00000180287; Group enriched (brain, choroid plexus).
DR neXtProt; NX_Q8N7P1; -.
DR OpenTargets; ENSG00000180287; -.
DR PharmGKB; PA142671168; -.
DR VEuPathDB; HostDB:ENSG00000180287; -.
DR eggNOG; KOG3603; Eukaryota.
DR GeneTree; ENSGT00950000183059; -.
DR HOGENOM; CLU_027021_0_0_1; -.
DR InParanoid; Q8N7P1; -.
DR OMA; CATKEQR; -.
DR OrthoDB; 1057467at2759; -.
DR PhylomeDB; Q8N7P1; -.
DR TreeFam; TF313378; -.
DR PathwayCommons; Q8N7P1; -.
DR BioGRID-ORCS; 200150; 10 hits in 1063 CRISPR screens.
DR ChiTaRS; PLD5; human.
DR GeneWiki; PLD5; -.
DR GenomeRNAi; 200150; -.
DR Pharos; Q8N7P1; Tbio.
DR PRO; PR:Q8N7P1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8N7P1; protein.
DR Bgee; ENSG00000180287; Expressed in pigmented layer of retina and 110 other tissues.
DR ExpressionAtlas; Q8N7P1; baseline and differential.
DR Genevisible; Q8N7P1; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR InterPro; IPR032803; PLDc_3.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR Pfam; PF13918; PLDc_3; 1.
DR SMART; SM00155; PLDc; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..536
FT /note="Inactive phospholipase D5"
FT /id="PRO_0000288606"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 215..242
FT /note="PLD phosphodiesterase 1"
FT DOMAIN 434..460
FT /note="PLD phosphodiesterase 2"
FT CARBOHYD 121
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 302
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..208
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_025724"
FT VAR_SEQ 1..108
FT /note="MEIRQHEWLSASPHEGFEQMRLKSRPKEPSPSLTRVGANFYSSVKQQDYSAS
FT VWLRRKDKLEHSQQKCIVIFALVCCFAILVALIFSAVDIMGEDEDGLSEKNCQNKC ->
FT MRMDSQKKIAKINVGK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_025725"
FT VAR_SEQ 1..62
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_025726"
FT VAR_SEQ 63
FT /note="H -> M (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_025727"
SQ SEQUENCE 536 AA; 61312 MW; 2FC94D6AB4A19934 CRC64;
MEIRQHEWLS ASPHEGFEQM RLKSRPKEPS PSLTRVGANF YSSVKQQDYS ASVWLRRKDK
LEHSQQKCIV IFALVCCFAI LVALIFSAVD IMGEDEDGLS EKNCQNKCRI ALVENIPEGL
NYSENAPFHL SLFQGWMNLL NMAKKSVDIV SSHWDLNHTH PSACQGQRLF EKLLQLTSQN
IEIKLVSDVT ADSKVLEALK LKGAEVTYMN MTAYNKGRLQ SSFWIVDKQH VYIGSAGLDW
QSLGQMKELG VIFYNCSCLV LDLQRIFALY SSLKFKSRVP QTWSKRLYGV YDNEKKLQLQ
LNETKSQAFV SNSPKLFCPK NRSFDIDAIY SVIDDAKQYV YIAVMDYLPI SSTSTKRTYW
PDLDAKIREA LVLRSVRVRL LLSFWKETDP LTFNFISSLK AICTEIANCS LKVKFFDLER
ENACATKEQK NHTFPRLNRN KYMVTDGAAY IGNFDWVGND FTQNAGTGLV INQADVRNNR
SIIKQLKDVF ERDWYSPYAK TLQPTKQPNC SSLFKLKPLS NKTATDDTGG KDPRNV
