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PLD5_MOUSE
ID   PLD5_MOUSE              Reviewed;         536 AA.
AC   Q3UNN8; Q3UVW3; Q497Q7;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Inactive phospholipase D5;
DE            Short=Inactive PLD 5;
DE   AltName: Full=Inactive choline phosphatase 5;
DE   AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5;
GN   Name=Pld5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC   STRAIN=C57BL/6J; TISSUE=Diencephalon;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q3UNN8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3UNN8-2; Sequence=VSP_025729;
CC       Name=3;
CC         IsoId=Q3UNN8-3; Sequence=VSP_025728;
CC   -!- SIMILARITY: Belongs to the phospholipase D family. {ECO:0000305}.
CC   -!- CAUTION: In contrast to other members of the family, it lacks the
CC       conserved active sites, suggesting that it has no phospholipase
CC       activity. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI00429.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK136851; BAE23146.1; -; mRNA.
DR   EMBL; AK136888; BAE23156.1; -; mRNA.
DR   EMBL; AK144116; BAE25709.1; -; mRNA.
DR   EMBL; BC100428; AAI00429.1; ALT_SEQ; mRNA.
DR   CCDS; CCDS15552.1; -. [Q3UNN8-1]
DR   RefSeq; NP_001182745.1; NM_001195816.1.
DR   RefSeq; NP_795890.2; NM_176916.4. [Q3UNN8-1]
DR   RefSeq; XP_006496963.1; XM_006496900.3. [Q3UNN8-3]
DR   RefSeq; XP_011237130.1; XM_011238828.1.
DR   RefSeq; XP_011237131.1; XM_011238829.2.
DR   RefSeq; XP_017176664.1; XM_017321175.1.
DR   AlphaFoldDB; Q3UNN8; -.
DR   SMR; Q3UNN8; -.
DR   STRING; 10090.ENSMUSP00000069326; -.
DR   GlyConnect; 2387; 1 N-Linked glycan (1 site).
DR   GlyGen; Q3UNN8; 3 sites, 1 N-linked glycan (1 site).
DR   iPTMnet; Q3UNN8; -.
DR   PhosphoSitePlus; Q3UNN8; -.
DR   PaxDb; Q3UNN8; -.
DR   PRIDE; Q3UNN8; -.
DR   ProteomicsDB; 289678; -. [Q3UNN8-1]
DR   ProteomicsDB; 289679; -. [Q3UNN8-2]
DR   ProteomicsDB; 289680; -. [Q3UNN8-3]
DR   Antibodypedia; 34707; 126 antibodies from 20 providers.
DR   Ensembl; ENSMUST00000065967; ENSMUSP00000069326; ENSMUSG00000055214. [Q3UNN8-1]
DR   GeneID; 319455; -.
DR   KEGG; mmu:319455; -.
DR   UCSC; uc007dtw.1; mouse. [Q3UNN8-1]
DR   CTD; 200150; -.
DR   MGI; MGI:2442056; Pld5.
DR   VEuPathDB; HostDB:ENSMUSG00000055214; -.
DR   eggNOG; KOG3603; Eukaryota.
DR   GeneTree; ENSGT00950000183059; -.
DR   InParanoid; Q3UNN8; -.
DR   OMA; CATKEQR; -.
DR   OrthoDB; 1057467at2759; -.
DR   PhylomeDB; Q3UNN8; -.
DR   TreeFam; TF313378; -.
DR   BioGRID-ORCS; 319455; 1 hit in 73 CRISPR screens.
DR   ChiTaRS; Pld5; mouse.
DR   PRO; PR:Q3UNN8; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q3UNN8; protein.
DR   Bgee; ENSMUSG00000055214; Expressed in cerebellar cortex and 31 other tissues.
DR   ExpressionAtlas; Q3UNN8; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   InterPro; IPR032803; PLDc_3.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   Pfam; PF13918; PLDc_3; 1.
DR   SMART; SM00155; PLDc; 2.
DR   PROSITE; PS50035; PLD; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Membrane; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..536
FT                   /note="Inactive phospholipase D5"
FT                   /id="PRO_0000288607"
FT   TOPO_DOM        1..68
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..536
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          215..242
FT                   /note="PLD phosphodiesterase 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"
FT   DOMAIN          434..460
FT                   /note="PLD phosphodiesterase 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"
FT   REGION          503..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        503..525
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        121
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        302
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..208
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_025728"
FT   VAR_SEQ         1..91
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_025729"
SQ   SEQUENCE   536 AA;  61066 MW;  6A9D11644CF0FBBF CRC64;
     MEIRQHEWLS ASPHEGFEQM RLKSRPKEPS PSLTRVGANF YSSVKQQDYS ASVWLRRKDK
     LEHSQQKCIV IFALVCCFAV LVALIFSAVD IMGEDEDGLS EKNCQNKCRI ALVENIPEGL
     NYSEDAPFHL PLFQGWMNLL NMAKKSVDIV SSHWDLNHTH PAACQGQRLF EKLLQLTSQN
     IEVKLVSDVT ADSKVLEALK LKGAEVTYMN MTAYNKGRLQ SSFWIVDKQH VYIGSAGLDW
     RSLGQMKELG VIFYNCSCLV LDLQRIFALY SSLKFKSRVP QTWSKRLYGV YDNEKKLQLQ
     LNETKSQAFV SNSPKLFCPK NRSFDIDAIY SVIDDAKQYV YIAVTDYLPI SSTSSKRTYW
     PDLDGKIREA LVLRSVKVRL LISFWKETDP LTFNFISSLK AICTEIANCS LKVKFFDLER
     ENACATKEQK NQTFPKLNRN KYMVTDGAAY IGNFDWVGND FTQNAGTGLV INQADVRDNR
     SIIKQLKDVF ERDWYSPYAK SIQPTKQPNC SSLSKLKSPS KQPAMANATG REPLSV
 
 
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