ASTE1_HUMAN
ID ASTE1_HUMAN Reviewed; 679 AA.
AC Q2TB18; B4DFL9; Q3MIB6; Q8N6G4; Q96JY1; Q9UHX6;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Protein asteroid homolog 1;
GN Name=ASTE1; ORFNames=HT001;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-626 (ISOFORM 1).
RC TISSUE=Brain cortex, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 285-679 (ISOFORM 1).
RC TISSUE=Hypothalamus;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
CC -!- FUNCTION: Possible role in EGF receptor signaling. {ECO:0000250}.
CC -!- INTERACTION:
CC Q2TB18; Q13426: XRCC4; NbExp=3; IntAct=EBI-2875586, EBI-717592;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2TB18-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2TB18-2; Sequence=VSP_056699, VSP_056700;
CC -!- SIMILARITY: Belongs to the asteroid family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF14876.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAH30274.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI03710.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK027806; BAB55383.1; -; mRNA.
DR EMBL; AK294156; BAG57480.1; -; mRNA.
DR EMBL; AC055733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79215.1; -; Genomic_DNA.
DR EMBL; BC030274; AAH30274.2; ALT_INIT; mRNA.
DR EMBL; BC103709; AAI03710.1; ALT_INIT; mRNA.
DR EMBL; BC110616; AAI10617.1; -; mRNA.
DR EMBL; AF113539; AAF14876.1; ALT_FRAME; mRNA.
DR CCDS; CCDS3068.1; -. [Q2TB18-1]
DR RefSeq; NP_001275879.1; NM_001288950.1.
DR RefSeq; NP_054784.2; NM_014065.3. [Q2TB18-1]
DR RefSeq; XP_016861755.1; XM_017006266.1. [Q2TB18-2]
DR RefSeq; XP_016861756.1; XM_017006267.1. [Q2TB18-2]
DR RefSeq; XP_016861757.1; XM_017006268.1. [Q2TB18-2]
DR RefSeq; XP_016861758.1; XM_017006269.1. [Q2TB18-2]
DR AlphaFoldDB; Q2TB18; -.
DR BioGRID; 118811; 19.
DR IntAct; Q2TB18; 18.
DR STRING; 9606.ENSP00000426421; -.
DR iPTMnet; Q2TB18; -.
DR PhosphoSitePlus; Q2TB18; -.
DR BioMuta; ASTE1; -.
DR DMDM; 121941802; -.
DR EPD; Q2TB18; -.
DR MassIVE; Q2TB18; -.
DR MaxQB; Q2TB18; -.
DR PaxDb; Q2TB18; -.
DR PeptideAtlas; Q2TB18; -.
DR PRIDE; Q2TB18; -.
DR ProteomicsDB; 4057; -.
DR ProteomicsDB; 61480; -. [Q2TB18-1]
DR Antibodypedia; 33340; 127 antibodies from 19 providers.
DR DNASU; 28990; -.
DR Ensembl; ENST00000264992.8; ENSP00000264992.3; ENSG00000034533.12. [Q2TB18-1]
DR Ensembl; ENST00000507978.5; ENSP00000421019.1; ENSG00000034533.12. [Q2TB18-2]
DR GeneID; 28990; -.
DR KEGG; hsa:28990; -.
DR MANE-Select; ENST00000264992.8; ENSP00000264992.3; NM_014065.4; NP_054784.2.
DR UCSC; uc003env.3; human. [Q2TB18-1]
DR CTD; 28990; -.
DR DisGeNET; 28990; -.
DR GeneCards; ASTE1; -.
DR HGNC; HGNC:25021; ASTE1.
DR HPA; ENSG00000034533; Low tissue specificity.
DR neXtProt; NX_Q2TB18; -.
DR OpenTargets; ENSG00000034533; -.
DR PharmGKB; PA142672577; -.
DR VEuPathDB; HostDB:ENSG00000034533; -.
DR eggNOG; ENOG502QQRA; Eukaryota.
DR GeneTree; ENSGT00390000010145; -.
DR HOGENOM; CLU_017330_1_0_1; -.
DR InParanoid; Q2TB18; -.
DR OMA; GYCPLSH; -.
DR OrthoDB; 966573at2759; -.
DR PhylomeDB; Q2TB18; -.
DR TreeFam; TF324582; -.
DR PathwayCommons; Q2TB18; -.
DR SignaLink; Q2TB18; -.
DR BioGRID-ORCS; 28990; 8 hits in 1080 CRISPR screens.
DR GenomeRNAi; 28990; -.
DR Pharos; Q2TB18; Tbio.
DR PRO; PR:Q2TB18; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q2TB18; protein.
DR Bgee; ENSG00000034533; Expressed in sperm and 151 other tissues.
DR ExpressionAtlas; Q2TB18; baseline and differential.
DR Genevisible; Q2TB18; HS.
DR GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR InterPro; IPR026832; Asteroid.
DR InterPro; IPR039436; Asteroid_dom.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR15665; PTHR15665; 1.
DR Pfam; PF12813; XPG_I_2; 1.
DR Pfam; PF00752; XPG_N; 1.
DR SUPFAM; SSF88723; SSF88723; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..679
FT /note="Protein asteroid homolog 1"
FT /id="PRO_0000310458"
FT REGION 625..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 506..520
FT /note="KEELQEDGAKMLYAE -> NVDPVPRQAQCLAPR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056699"
FT VAR_SEQ 521..679
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056700"
FT CONFLICT 303
FT /note="Q -> P (in Ref. 5; AAF14876)"
FT /evidence="ECO:0000305"
FT CONFLICT 312..314
FT /note="CGT -> YGS (in Ref. 5; AAF14876)"
FT /evidence="ECO:0000305"
FT CONFLICT 318
FT /note="P -> T (in Ref. 5; AAF14876)"
FT /evidence="ECO:0000305"
FT CONFLICT 321..322
FT /note="LN -> SD (in Ref. 5; AAF14876)"
FT /evidence="ECO:0000305"
FT CONFLICT 331
FT /note="V -> G (in Ref. 5; AAF14876)"
FT /evidence="ECO:0000305"
FT CONFLICT 337..339
FT /note="QLS -> RVP (in Ref. 5; AAF14876)"
FT /evidence="ECO:0000305"
FT CONFLICT 352..354
FT /note="ILP -> FLH (in Ref. 5; AAF14876)"
FT /evidence="ECO:0000305"
FT CONFLICT 362
FT /note="Q -> R (in Ref. 5; AAF14876)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 679 AA; 77093 MW; 488DE83A8CD8E82B CRC64;
MGIRGLMSFV EDHSNEFFTD LKLRDTKIVI DGYALFHRLC FSSNLDLRYG GDYDSFADVV
QKFFESLFAC NICPYVVLDG GCDISDKKLT TLKDRAREKI QMAHSLSVGG SGYVCPLLIR
EVFIQVLIKL RVCFVQCFSE ADRDIMTLAN HWNCPVLSSD SDFCIFDLKT GFCPLNSFQW
RNMNTIKGTQ NYIPAKCFSL DAFCHHFSNM NKALLPLFAV LCGNDHVNLP IMETFLSKAR
LPLGATSSKG RRHHRILGLL NWLSHFANPT EALDNVLKYL PKKDRENVKE LLCCSMEEYQ
QSQVKLQDFF QCGTYVCPDA LNLGLPEWVL VALAKGQLSP FISDALVLRR TILPTQVENM
QQPNAHRISQ PIRQIIYGLL LNASPHLDKT SWNALPPQPL AFSEVERINK NIRTSIIDAV
ELAKDHSDLS RLTELSLRRR QMLLLETLKV KQTILEPIPT SLKLPIAVSC YWLQHTETKA
KLHHLQSLLL TMLVGPLIAI INSPGKEELQ EDGAKMLYAE FQRVKAQTRL GTRLDLDTAH
IFCQWQSCLQ MGMYLNQLLS TPLPEPDLTR LYSGSLVHGL CQQLLASTSV ESLLSICPEA
KQLYEYLFNA TRSYAPAEIF LPKGRSNSKK KRQKKQNTSC SKNRGRTTAH TKCWYEGNNR
FGLLMVENLE EHSEASNIE
