ID   ASTE1_MOUSE             Reviewed;         672 AA.
AC   Q8BIR2; Q4KMN1; Q80VC2;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Protein asteroid homolog 1;
GN   Name=Aste1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Head;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6NCr, and NMRI;
RC   TISSUE=Hematopoietic stem cell, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Possible role in EGF receptor signaling. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8BIR2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8BIR2-2; Sequence=VSP_029285, VSP_029286;
CC   -!- SIMILARITY: Belongs to the asteroid family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH48866.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK030661; BAC27067.1; -; mRNA.
DR   EMBL; BC048866; AAH48866.1; ALT_INIT; mRNA.
DR   EMBL; BC098471; AAH98471.1; -; mRNA.
DR   CCDS; CCDS23465.1; -. [Q8BIR2-1]
DR   CCDS; CCDS90653.1; -. [Q8BIR2-2]
DR   RefSeq; NP_079927.2; NM_025651.4. [Q8BIR2-1]
DR   RefSeq; XP_006511847.1; XM_006511784.3. [Q8BIR2-1]
DR   RefSeq; XP_006511848.1; XM_006511785.3.
DR   RefSeq; XP_006511851.1; XM_006511788.3.
DR   RefSeq; XP_006511852.1; XM_006511789.3.
DR   AlphaFoldDB; Q8BIR2; -.
DR   STRING; 10090.ENSMUSP00000035181; -.
DR   iPTMnet; Q8BIR2; -.
DR   PhosphoSitePlus; Q8BIR2; -.
DR   EPD; Q8BIR2; -.
DR   PaxDb; Q8BIR2; -.
DR   PRIDE; Q8BIR2; -.
DR   ProteomicsDB; 277079; -. [Q8BIR2-1]
DR   ProteomicsDB; 277080; -. [Q8BIR2-2]
DR   Antibodypedia; 33340; 127 antibodies from 19 providers.
DR   DNASU; 66595; -.
DR   Ensembl; ENSMUST00000035181; ENSMUSP00000035181; ENSMUSG00000032567. [Q8BIR2-1]
DR   Ensembl; ENSMUST00000123807; ENSMUSP00000149596; ENSMUSG00000032567. [Q8BIR2-2]
DR   GeneID; 66595; -.
DR   KEGG; mmu:66595; -.
DR   UCSC; uc009ric.2; mouse. [Q8BIR2-1]
DR   UCSC; uc009rid.2; mouse. [Q8BIR2-2]
DR   CTD; 28990; -.
DR   MGI; MGI:1913845; Aste1.
DR   VEuPathDB; HostDB:ENSMUSG00000032567; -.
DR   eggNOG; ENOG502QQRA; Eukaryota.
DR   GeneTree; ENSGT00390000010145; -.
DR   HOGENOM; CLU_017330_1_0_1; -.
DR   InParanoid; Q8BIR2; -.
DR   OMA; GYCPLSH; -.
DR   OrthoDB; 966573at2759; -.
DR   PhylomeDB; Q8BIR2; -.
DR   TreeFam; TF324582; -.
DR   BioGRID-ORCS; 66595; 4 hits in 71 CRISPR screens.
DR   ChiTaRS; Aste1; mouse.
DR   PRO; PR:Q8BIR2; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q8BIR2; protein.
DR   Bgee; ENSMUSG00000032567; Expressed in spermatid and 152 other tissues.
DR   ExpressionAtlas; Q8BIR2; baseline and differential.
DR   Genevisible; Q8BIR2; MM.
DR   InterPro; IPR026832; Asteroid.
DR   InterPro; IPR039436; Asteroid_dom.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR15665; PTHR15665; 1.
DR   Pfam; PF12813; XPG_I_2; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..672
FT                   /note="Protein asteroid homolog 1"
FT                   /id="PRO_0000310459"
FT   VAR_SEQ         1..61
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_029285"
FT   VAR_SEQ         62..78
FT                   /note="KFFESLFVCHICPYVVL -> MAILSSTDFASILTWSS (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_029286"
FT   CONFLICT        90
FT                   /note="T -> A (in Ref. 2; AAH98471)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        178
FT                   /note="F -> Y (in Ref. 2; AAH98471)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        603
FT                   /note="E -> G (in Ref. 2; AAH98471)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   672 AA;  76370 MW;  51F219D759443543 CRC64;
     MGIRGLMSFV EDYSNEFFVD LKLRNTKLII DGYSLFHRLC FNSDLELRYG GDYDLFADVV
     QKFFESLFVC HICPYVVLDG GCDISDKKLT TLKDRAKEKI QAARSLSLGG GGNVCPLLIR
     EVFIQVLIRL EVCFVQSFSE ADRDIMTLAN HWNCPVLSSD SDFCIFDLRS GFCSLNSFQW
     RNLNTIKDTQ DYYIPARSFS LNAFCHYFNN MNKALLPLFA VLCGNDHVNL PIMDTFISKV
     RLPLSSKGRR YHRVLGLLNW LSHFDDPTEA LDNVLKSLPK KSRENVKELL CCSMEEYQQS
     PVKLQDFFQY GSYVCTDASD LGLPEWVLGA LAKGQLPPFI SDALVLRRTF LHTQVENMQR
     PNAHRISQPI RQIIYGLLLN GPSHAEDIAQ NTLPSQLLAF NEVERIDTNI KTSTVYAKQL
     LKDQCDLSKL AELPLARRQM LLLEALKVKQ VVLESIPTFL KLPIAVTCYW LQSTEAKAKL
     HHLQALLLGM LREPLHAIVN SPGTEDPQRG GAKMLYEELC QVKAPMRPGP RVDLDTAHVF
     CQWQSCLQMG LYLNQLLSTP LPEPNLTWLY NGSLVHRLCQ QLPASSSVES LLSLCPEAKQ
     LYEHLFNATK SYAPAELFLP KTKSKSKKKR QKKKVASLGT TADAKHWYDR SNRFGPLMPE
     SLEEHVENSE LE