ID   PLD_POLDI               Reviewed;          22 AA.
AC   P0DV63;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   25-MAY-2022, sequence version 1.
DT   03-AUG-2022, entry version 2.
DE   RecName: Full=Polydim-I {ECO:0000303|PubMed:26930596};
OS   Polybia dimorpha (Neotropical wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Polistinae; Epiponini; Polybia.
OX   NCBI_TaxID=2893826;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, SYNTHESIS, FUNCTION, AND SUBCELLULAR
RP   LOCATION.
RC   TISSUE=Venom;
RX   PubMed=26930596; DOI=10.1371/journal.pone.0149729;
RA   das Neves R.C., Trentini M.M., de Castro e Silva J., Simon K.S.,
RA   Bocca A.L., Silva L.P., Mortari M.R., Kipnis A., Junqueira-Kipnis A.P.;
RT   "Antimycobacterial activity of a new peptide polydim-I isolated from
RT   neotropical social wasp Polybia dimorpha.";
RL   PLoS ONE 11:e0149729-e0149729(2016).
CC   -!- FUNCTION: Antibacterial peptide. Acts on the Mycobacterium abscessus
CC       subsp. massiliense cell wall. Reduces 40-50% of the bacterial load in
CC       macrophages infected with different M.abscessus strains. Is not
CC       cytotoxic towards mammalian cells, and shows no hemolytic activity
CC       against human erythrocytes. In vivo, reduces the bacterial load in the
CC       lungs, spleen, and liver of highly susceptible mice intravenously
CC       infected with M.abscessus. {ECO:0000269|PubMed:26930596}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26930596}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:26930596}.
CC   -!- MASS SPECTROMETRY: Mass=2441.7; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:26930596};
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted.
FT   PEPTIDE         1..22
FT                   /note="Polydim-I"
FT                   /evidence="ECO:0000269|PubMed:26930596"
FT                   /id="PRO_0000455165"
SQ   SEQUENCE   22 AA;  2442 MW;  6E099947D1B23E76 CRC64;
     AVAGEKLWLL PHLLKMLLTP TP