ID   PLE4_PSEAM              Reviewed;          68 AA.
AC   Q90ZX8; Q90ZX9;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Pleurocidin-like peptide WF4;
DE   Flags: Precursor;
GN   Name=ple4;
OS   Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Pleuronectidae;
OC   Pseudopleuronectes.
OX   NCBI_TaxID=8265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11113283; DOI=10.1016/s0145-305x(00)00052-5;
RA   Douglas S.E., Gallant J.W., Gong Z., Hew C.-L.;
RT   "Cloning and developmental expression of a family of pleurocidin-like
RT   antimicrobial peptides from winter flounder, Pleuronectes americanus
RT   (Walbaum).";
RL   Dev. Comp. Immunol. 25:137-147(2001).
CC   -!- FUNCTION: Antimicrobial peptide. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pleurocidin family. {ECO:0000305}.
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DR   EMBL; AF301514; AAK52849.1; -; Genomic_DNA.
DR   EMBL; AF301515; AAK52850.1; -; Genomic_DNA.
DR   PDB; 6RZC; NMR; -; A=23-47.
DR   PDBsum; 6RZC; -.
DR   AlphaFoldDB; Q90ZX8; -.
DR   SMR; Q90ZX8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR012515; Antimicrobial12.
DR   Pfam; PF08107; Antimicrobial12; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic; Antimicrobial; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         23..47
FT                   /note="Pleurocidin-like peptide WF4"
FT                   /id="PRO_0000000279"
FT   PROPEP          48..68
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000000280"
FT   TURN            29..32
FT                   /evidence="ECO:0007829|PDB:6RZC"
FT   TURN            35..41
FT                   /evidence="ECO:0007829|PDB:6RZC"
FT   STRAND          42..45
FT                   /evidence="ECO:0007829|PDB:6RZC"
SQ   SEQUENCE   68 AA;  7732 MW;  46C16F877FDCBCBC CRC64;
     MKFTATFLMM FIFVLMVEPG ECGWGSIFKH GRHAAKHIGH AAVNHYLGEQ QDLDKRAVDE
     DPNVIVFE