PLEC_CAUVC
ID PLEC_CAUVC Reviewed; 842 AA.
AC P37894;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Non-motile and phage-resistance protein;
DE EC=2.7.13.3;
GN Name=pleC; OrderedLocusNames=CC_2482;
OS Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=190650;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=8421698; DOI=10.1073/pnas.90.2.630;
RA Wang S.P., Sharma P.L., Schoenlein P.V., Ely B.;
RT "A histidine protein kinase is involved in polar organelle development in
RT Caulobacter crescentus.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:630-634(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=11259647; DOI=10.1073/pnas.061029298;
RA Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT "Complete genome sequence of Caulobacter crescentus.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
RN [3]
RP PHOSPHORYLATION OF PLED.
RX PubMed=15075296; DOI=10.1101/gad.289504;
RA Paul R., Weiser S., Amiot N.C., Chan C., Schirmer T., Giese B., Jenal U.;
RT "Cell cycle-dependent dynamic localization of a bacterial response
RT regulator with a novel di-guanylate cyclase output domain.";
RL Genes Dev. 18:715-727(2004).
CC -!- FUNCTION: Member of the two-component regulatory system involved in the
CC regulation of polar organelle development. PleC functions as a
CC membrane-associated protein kinase that transfers phosphate to the
CC response regulator PleD, leading to its activation.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3;
CC -!- INTERACTION:
CC P37894; Q9A5I5: pleD; NbExp=4; IntAct=EBI-1784742, EBI-1784732;
CC P37894; Q45976: divK; Xeno; NbExp=8; IntAct=EBI-1784742, EBI-1784754;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; M91449; AAA23052.1; -; Genomic_DNA.
DR EMBL; AE005673; AAK24453.1; -; Genomic_DNA.
DR PIR; A87557; A87557.
DR PIR; S27533; S27533.
DR RefSeq; NP_421285.1; NC_002696.2.
DR RefSeq; WP_010920340.1; NC_002696.2.
DR AlphaFoldDB; P37894; -.
DR SMR; P37894; -.
DR DIP; DIP-44286N; -.
DR IntAct; P37894; 3.
DR MINT; P37894; -.
DR STRING; 190650.CC_2482; -.
DR PRIDE; P37894; -.
DR EnsemblBacteria; AAK24453; AAK24453; CC_2482.
DR KEGG; ccr:CC_2482; -.
DR PATRIC; fig|190650.5.peg.2500; -.
DR eggNOG; COG2202; Bacteria.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_000445_114_71_5; -.
DR OMA; GFAFHWQ; -.
DR BioCyc; CAULO:CC2482-MON; -.
DR Proteomes; UP000001816; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IDA:CACAO.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IDA:CACAO.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00989; PAS; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47384; SSF47384; 1.
DR SUPFAM; SSF55785; SSF55785; 2.
DR SUPFAM; SSF55874; SSF55874; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50112; PAS; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cell cycle; Cell membrane; Differentiation; Kinase; Membrane;
KW Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase;
KW Transmembrane; Transmembrane helix; Two-component regulatory system.
FT CHAIN 1..842
FT /note="Non-motile and phage-resistance protein"
FT /id="PRO_0000074852"
FT TRANSMEM 29..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 318..389
FT /note="PAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT DOMAIN 607..830
FT /note="Histidine kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT MOD_RES 610
FT /note="Phosphohistidine; by autocatalysis"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT CONFLICT 744
FT /note="A -> V (in Ref. 1; AAA23052)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 842 AA; 89560 MW; DCFF4F092DE2CBF8 CRC64;
MGRHGGPAAA GPTAPSAVRA KAVNAPSQVF VRIAILAALL LLAVYTAFGV HRLQREAMAQ
PGGAPLAAKA DLIAGRVDAN LAAQRAGLSA AADLLKRDPG ATMDAAETTL RAAGGEAAAV
AVVSEAGVVA VAGRDDGADW KAAALAAGAS GRTNWVGSVG ETGRLYVATT TSLDRARAFV
IASGDASRLV ADPEKGESGA LALPDGKLIA ARGRGVQGAG ALREAFALSI EDLGDGPAAV
RGQAADGALL DVAVRPVAQG ALLAVAAAPT RSVANLDRQV MEGAFSLLVP LGVGIALALL
LMIQSRKAEV AHREFIDSER RFRLAVEAAR CGIWEWDLNG DQVYLSDVTG AMFGWGGGGV
VSGQDLLERI SIDHRERVRQ ALANAAMYGA FDVSFRVPAS EQGARSLWID ARGQGFGKPG
SEGHARIIGV ALDVTEERIA QARAQAAENR LRDAIESVSE AFVLWDRQGR LLMCNRNYRS
VFSLEPKILK PGAARAEVNR FAALAIKQDH PAPDGAKGVR EAEMMDGRWI QISERRTAEG
GLVMTAADIT AIKTQEEARR RNEEQLQNAV AGLERSQEQL AELARKYETE KVKAESANKA
KSEFLANMSH ELRTPLNAIN GFSEIMMNEM FGPLGDQRYK GYSQDIHSSG QHLLALINDI
LDMSKIEAGK MNLKFESMHL EDVAEDAVRL VRNRAEAAGL KLDIDFPQLP EIEADYRAVK
QVLLNLLSNA IKFTPRAGSV TVRAEVRRDP FGDLIKVSVT DTGIGIAKED LARLAKPFEQ
VESQFSKTTQ GTGLGLALTK SLITMHDGVL EMHSTPGEGT TVSFTLPVRH SDQKITRDFV
AA
