ID   PLEK_CANLF              Reviewed;         351 AA.
AC   Q6Q308;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Pleckstrin;
GN   Name=PLEK;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Platelet;
RA   Boudreaux M.K.;
RT   "Canine pleckstrin.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Major protein kinase C substrate of platelets. {ECO:0000250}.
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DR   EMBL; AY563035; AAS67002.1; -; mRNA.
DR   RefSeq; NP_001003363.1; NM_001003363.2.
DR   AlphaFoldDB; Q6Q308; -.
DR   SMR; Q6Q308; -.
DR   STRING; 9615.ENSCAFP00000053827; -.
DR   PaxDb; Q6Q308; -.
DR   PRIDE; Q6Q308; -.
DR   Ensembl; ENSCAFT00030043432; ENSCAFP00030037916; ENSCAFG00030023596.
DR   Ensembl; ENSCAFT00040011877; ENSCAFP00040010298; ENSCAFG00040006341.
DR   Ensembl; ENSCAFT00845041284; ENSCAFP00845032366; ENSCAFG00845023363.
DR   GeneID; 442956; -.
DR   KEGG; cfa:442956; -.
DR   CTD; 5341; -.
DR   VEuPathDB; HostDB:ENSCAFG00845023363; -.
DR   eggNOG; ENOG502QQIA; Eukaryota.
DR   GeneTree; ENSGT00940000157885; -.
DR   HOGENOM; CLU_067828_0_0_1; -.
DR   InParanoid; Q6Q308; -.
DR   OMA; MEPKQIR; -.
DR   OrthoDB; 717547at2759; -.
DR   TreeFam; TF332246; -.
DR   Reactome; R-CFA-114608; Platelet degranulation.
DR   Proteomes; UP000002254; Chromosome 10.
DR   Bgee; ENSCAFG00000003260; Expressed in granulocyte and 47 other tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0031532; P:actin cytoskeleton reorganization; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd04445; DEP_PLEK1; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 2.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR037371; PLEK_DEP.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00169; PH; 2.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00233; PH; 2.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
PE   2: Evidence at transcript level;
KW   Acetylation; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..351
FT                   /note="Pleckstrin"
FT                   /id="PRO_0000053858"
FT   DOMAIN          4..101
FT                   /note="PH 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          136..221
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   DOMAIN          244..348
FT                   /note="PH 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   MOD_RES         64
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P08567"
FT   MOD_RES         113
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P08567"
FT   MOD_RES         117
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P08567"
SQ   SEQUENCE   351 AA;  40210 MW;  8B1F54A41CFEDFC3 CRC64;
     MEPKRIREGY LVKRGSVFNT WKPMWVVLLE DGIEFYKKKS DNSPKGMIPL KGSTLTSPCQ
     DFGKRMFVFK ITTTKQQDHF FQAAFLEERD SWVRDTKKAI KCIEGGQKFA RKSTRRSIRL
     PETVDLGALY LSMKDIEKGI KELNLEKDKK IFNHCFTGNC VIDWLVSNKS VRNRQEGLMI
     ASSLLGEGYL QPAGELSKNA ADGMAEHPFL DNPDAFYYFP DSGFFCEENS SDDDVILKEE
     FRGVIIKQGC LLKQGHRRKN WKVRKFILRE DPAYLHYYDP AAGGEEPLGA IHLRGCVVTS
     VESNPDVRKS EEENLFEIIT ADEVHYFLQA ATPKERTEWI KAIQVASRTG K