PLET1_ARATH
ID PLET1_ARATH Reviewed; 574 AA.
AC Q5YGP8; Q6PQQ6; Q9LT37;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=AP2-like ethylene-responsive transcription factor PLT1 {ECO:0000303|PubMed:15454085};
DE AltName: Full=Protein AINTEGUMENTA-LIKE 3 {ECO:0000303|PubMed:15988559};
DE AltName: Full=Protein PLETHORA 1 {ECO:0000303|PubMed:15454085};
GN Name=PLT1 {ECO:0000303|PubMed:15454085};
GN Synonyms=AIL3 {ECO:0000303|PubMed:15988559};
GN OrderedLocusNames=At3g20840 {ECO:0000312|Araport:AT3G20840};
GN ORFNames=MOE17.15 {ECO:0000312|EMBL:BAB02492.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND INDUCTION.
RC STRAIN=cv. Columbia;
RX PubMed=15454085; DOI=10.1016/j.cell.2004.09.018;
RA Aida M., Beis D., Heidstra R., Willemsen V., Blilou I., Galinha C.,
RA Nussaume L., Noh Y.-S., Amasino R., Scheres B.;
RT "The PLETHORA genes mediate patterning of the Arabidopsis root stem cell
RT niche.";
RL Cell 119:109-120(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 43-574.
RA Pan Y., Gong W., Liu D., Fu Q., Mei W.-Q., Song W.-Q., Ma L.-G., Luo J.-C.,
RA Deng X.-W., Zhu Y.-X.;
RT "Molecular cloning, expression, phylogenetic and functional
RT characterization of the Arabidopsis AP2/EREBP transcription factor
RT family.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=15635403; DOI=10.1038/nature03184;
RA Blilou I., Xu J., Wildwater M., Willemsen V., Paponov I., Friml J.,
RA Heidstra R., Aida M., Palme K., Scheres B.;
RT "The PIN auxin efflux facilitator network controls growth and patterning in
RT Arabidopsis roots.";
RL Nature 433:39-44(2005).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=15988559; DOI=10.1007/s11103-005-0955-6;
RA Nole-Wilson S., Tranby T.L., Krizek B.A.;
RT "AINTEGUMENTA-like (AIL) genes are expressed in young tissues and may
RT specify meristematic or division-competent states.";
RL Plant Mol. Biol. 57:613-628(2005).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16407444; DOI=10.1104/pp.105.073783;
RA Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL Plant Physiol. 140:411-432(2006).
RN [8]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16424342; DOI=10.1126/science.1121790;
RA Xu J., Hofhuis H., Heidstra R., Sauer M., Friml J., Scheres B.;
RT "A molecular framework for plant regeneration.";
RL Science 311:385-388(2006).
RN [9]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=20190735; DOI=10.1038/nature08843;
RA Smith Z.R., Long J.A.;
RT "Control of Arabidopsis apical-basal embryo polarity by antagonistic
RT transcription factors.";
RL Nature 464:423-426(2010).
RN [10]
RP REGULATION BY RGF.
RX PubMed=20798316; DOI=10.1126/science.1191132;
RA Matsuzaki Y., Ogawa-Ohnishi M., Mori A., Matsubayashi Y.;
RT "Secreted peptide signals required for maintenance of root stem cell niche
RT in Arabidopsis.";
RL Science 329:1065-1067(2010).
CC -!- FUNCTION: Probably acts as a transcriptional activator. Binds to the
CC GCC-box pathogenesis-related promoter element. May be involved in the
CC regulation of gene expression by stress factors and by components of
CC stress signal transduction pathways (By similarity). Master regulator
CC of basal/root fate. Essential for root quiescent center (QC) and
CC columella specification, stem cell activity, as well as for
CC establishment of the stem cell niche during embryogenesis. Modulates
CC the root polar auxin transport by regulating the distribution of PIN
CC genes. Essential role in respecifying pattern and polarity in damaged
CC roots. Direct target of the transcriptional corepressor TPL. Expression
CC levels and patterns regulated post-transcriptionally by root meristem
CC growth factors (RGFs). {ECO:0000250|UniProtKB:Q9LND1,
CC ECO:0000269|PubMed:15454085, ECO:0000269|PubMed:15635403,
CC ECO:0000269|PubMed:16424342, ECO:0000269|PubMed:20190735}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, seedlings, flowers, and
CC siliques. Also detected at low levels in leaves. In roots, specifically
CC detected in the distal root meristem, including the QC. This tissue
CC specificity is regulated by auxin gradient and depends on PIN proteins.
CC {ECO:0000269|PubMed:15454085, ECO:0000269|PubMed:15635403,
CC ECO:0000269|PubMed:15988559, ECO:0000269|PubMed:16424342,
CC ECO:0000269|PubMed:20190735}.
CC -!- DEVELOPMENTAL STAGE: Accumulates in the basal embryo region that gives
CC rise to hypocotyl, root, and root stem cells. Expressed in the root
CC meristem throughout embryo development. {ECO:0000269|PubMed:15454085,
CC ECO:0000269|PubMed:20190735}.
CC -!- INDUCTION: By auxin accumulation. {ECO:0000269|PubMed:15454085}.
CC -!- PTM: Stabilized in root meristems by reactive oxygen species (ROS)
CC mediated oxidative post-translational modification triggered by RGF1
CC hormone peptide in a RITF1-dependent manner.
CC {ECO:0000250|UniProtKB:Q5YGP7}.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. AP2
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB02492.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY506549; AAS86335.1; -; mRNA.
DR EMBL; AB025629; BAB02492.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE76430.1; -; Genomic_DNA.
DR EMBL; AY585682; AAS97939.1; -; mRNA.
DR RefSeq; NP_188720.2; NM_112975.3.
DR AlphaFoldDB; Q5YGP8; -.
DR SMR; Q5YGP8; -.
DR STRING; 3702.AT3G20840.1; -.
DR PaxDb; Q5YGP8; -.
DR PRIDE; Q5YGP8; -.
DR ProteomicsDB; 234769; -.
DR EnsemblPlants; AT3G20840.1; AT3G20840.1; AT3G20840.
DR GeneID; 821632; -.
DR Gramene; AT3G20840.1; AT3G20840.1; AT3G20840.
DR KEGG; ath:AT3G20840; -.
DR Araport; AT3G20840; -.
DR TAIR; locus:2091891; AT3G20840.
DR eggNOG; ENOG502QSTN; Eukaryota.
DR HOGENOM; CLU_013549_5_0_1; -.
DR InParanoid; Q5YGP8; -.
DR OMA; KTDYDMP; -.
DR OrthoDB; 455685at2759; -.
DR PhylomeDB; Q5YGP8; -.
DR PRO; PR:Q5YGP8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q5YGP8; baseline and differential.
DR Genevisible; Q5YGP8; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0007389; P:pattern specification process; IMP:TAIR.
DR GO; GO:0048364; P:root development; IMP:TAIR.
DR GO; GO:0010449; P:root meristem growth; IGI:TAIR.
DR GO; GO:0019827; P:stem cell population maintenance; IMP:TAIR.
DR GO; GO:0000723; P:telomere maintenance; IDA:TAIR.
DR CDD; cd00018; AP2; 2.
DR Gene3D; 3.30.730.10; -; 2.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR Pfam; PF00847; AP2; 2.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 2.
DR SUPFAM; SSF54171; SSF54171; 2.
DR PROSITE; PS51032; AP2_ERF; 2.
PE 2: Evidence at transcript level;
KW Activator; Auxin signaling pathway; Developmental protein; DNA-binding;
KW Ethylene signaling pathway; Nucleus; Reference proteome; Repeat;
KW Stress response; Transcription; Transcription regulation.
FT CHAIN 1..574
FT /note="AP2-like ethylene-responsive transcription factor
FT PLT1"
FT /id="PRO_0000297930"
FT DNA_BIND 181..247
FT /note="AP2/ERF 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT DNA_BIND 283..341
FT /note="AP2/ERF 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 536..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 347
FT /note="V -> L (in Ref. 4; AAS97939)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 574 AA; 62875 MW; 3904AF3BD26B7E1C CRC64;
MNSNNWLGFP LSPNNSSLPP HEYNLGLVSD HMDNPFQTQE WNMINPHGGG GDEGGEVPKV
ADFLGVSKPD ENQSNHLVAY NDSDYYFHTN SLMPSVQSND VVVAACDSNT PNNSSYHELQ
ESAHNLQSLT LSMGTTAGNN VVDKASPSET TGDNASGGAL AVVETATPRR ALDTFGQRTS
IYRGVTRHRW TGRYEAHLWD NSCRREGQSR KGRQVYLGGY DKEDKAARSY DLAALKYWGP
STTTNFPITN YEKEVEEMKH MTRQEFVAAI RRKSSGFSRG ASMYRGVTRH HQHGRWQARI
GRVAGNKDLY LGTFSTEEEA AEAYDIAAIK FRGLNAVTNF EINRYDVKAI LESSTLPIGG
GAAKRLKEAQ ALESSRKREA EMIALGSSFQ YGGGSSTGSG STSSRLQLQP YPLSIQQPLE
PFLSLQNNDI SHYNNNNAHD SSSFNHHSYI QTQLHLHQQT NNYLQQQSSQ NSQQLYNAYL
HSNPALLHGL VSTSIVDNNN NNGGSSGSYN TAAFLGNHGI GIGSSSTVGS TEEFPTVKTD
YDMPSSDGTG GYSGWTSESV QGSNPGGVFT MWNE
