PLET1_HUMAN
ID PLET1_HUMAN Reviewed; 207 AA.
AC Q6UQ28; Q6UQ24; Q6UQ25; Q6UQ27;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Placenta-expressed transcript 1 protein;
DE Flags: Precursor;
GN Name=PLET1; Synonyms=C11orf34;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-149, AND VARIANT PRO-142.
RX PubMed=15203209; DOI=10.1016/j.ygeno.2004.02.006;
RA Zhao S.-H., Simmons D.G., Cross J.C., Scheetz T.E., Casavant T.L.,
RA Soares M.B., Tuggle C.K.;
RT "PLET1 (C11orf34), a highly expressed and processed novel gene in pig and
RT mouse placenta, is transcribed but poorly spliced in human.";
RL Genomics 84:114-125(2004).
CC -!- FUNCTION: Modulates leading keratinocyte migration and cellular
CC adhesion to matrix proteins during a wound-healing response and
CC promotes wound repair. May play a role during trichilemmal
CC differentiation of the hair follicle (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Lipid-anchor,
CC GPI-anchor {ECO:0000250}. Note=Localized at the apical membrane of the
CC most differentiated keratinocytes of the outer root sheath (ORS),
CC clustered mainly in planar regions of the plasma membrane at the base
CC of microvilli. {ECO:0000250}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- PTM: GPI-anchored. {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP002884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY364431; AAQ72434.1; -; mRNA.
DR EMBL; AY364432; AAQ72435.1; -; Transcribed_RNA.
DR EMBL; AY364434; AAQ72437.1; -; mRNA.
DR EMBL; AY364435; AAQ72438.1; -; mRNA.
DR CCDS; CCDS44732.1; -.
DR RefSeq; NP_001138496.1; NM_001145024.1.
DR AlphaFoldDB; Q6UQ28; -.
DR STRING; 9606.ENSP00000341412; -.
DR GlyGen; Q6UQ28; 2 sites.
DR iPTMnet; Q6UQ28; -.
DR PhosphoSitePlus; Q6UQ28; -.
DR BioMuta; PLET1; -.
DR DMDM; 172046151; -.
DR PaxDb; Q6UQ28; -.
DR PRIDE; Q6UQ28; -.
DR ProteomicsDB; 67420; -.
DR Antibodypedia; 51858; 69 antibodies from 16 providers.
DR DNASU; 349633; -.
DR Ensembl; ENST00000338832.4; ENSP00000341412.2; ENSG00000188771.5.
DR GeneID; 349633; -.
DR KEGG; hsa:349633; -.
DR MANE-Select; ENST00000338832.4; ENSP00000341412.2; NM_001145024.1; NP_001138496.1.
DR UCSC; uc009yyp.3; human.
DR CTD; 349633; -.
DR DisGeNET; 349633; -.
DR GeneCards; PLET1; -.
DR HGNC; HGNC:30053; PLET1.
DR HPA; ENSG00000188771; Not detected.
DR MIM; 611904; gene.
DR neXtProt; NX_Q6UQ28; -.
DR OpenTargets; ENSG00000188771; -.
DR PharmGKB; PA134915529; -.
DR VEuPathDB; HostDB:ENSG00000188771; -.
DR eggNOG; ENOG502RTZP; Eukaryota.
DR GeneTree; ENSGT00390000014690; -.
DR HOGENOM; CLU_099483_0_0_1; -.
DR InParanoid; Q6UQ28; -.
DR OMA; YMTVLEA; -.
DR OrthoDB; 1472106at2759; -.
DR PhylomeDB; Q6UQ28; -.
DR TreeFam; TF344172; -.
DR PathwayCommons; Q6UQ28; -.
DR Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR BioGRID-ORCS; 349633; 8 hits in 195 CRISPR screens.
DR ChiTaRS; PLET1; human.
DR GenomeRNAi; 349633; -.
DR Pharos; Q6UQ28; Tbio.
DR PRO; PR:Q6UQ28; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6UQ28; protein.
DR Bgee; ENSG00000188771; Expressed in colonic epithelium and 21 other tissues.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0001953; P:negative regulation of cell-matrix adhesion; ISS:UniProtKB.
DR GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0035313; P:wound healing, spreading of epidermal cells; ISS:UniProtKB.
DR InterPro; IPR026184; PLET1.
DR PANTHER; PTHR22527; PTHR22527; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Differentiation; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..187
FT /note="Placenta-expressed transcript 1 protein"
FT /id="PRO_0000320952"
FT PROPEP 188..207
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000424667"
FT LIPID 187
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 122
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 142
FT /note="S -> P (in dbSNP:rs2564872)"
FT /evidence="ECO:0000269|PubMed:15203209"
FT /id="VAR_039321"
SQ SEQUENCE 207 AA; 23385 MW; F607E6D5A7EE1B02 CRC64;
MAVFHDMLLQ PLGMFLCLSL QLSSATFIRY SSTCFTFDEY YTITLDIKAS SHIYESNAVY
SVFVPVNDSV YAVVMKTLDE NSDSAGLWQR ADKNCYSNST YYVKDQYMTV LEAQWQAPEP
ENITEVEIQA FTVQIRALPI LSTLKLREKL STLALAAKIP QSSAFKPFFM ITPKSIRLEG
LANQVFSSPI TEAIYILLAF LTSTLLF
